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Response differences of arbuscular mycorrhizal fungi communities in the roots of an aquatic and a semiaquatic species to various flooding regimes

Background and aims: Arbuscular mycorrhizal fungi (AMF) are ubiquitous in wetland habitats, but their diversity and distribution pattern in these habitats is poorly understood. Under varying hydrological conditions, AMF communities in roots of different wetland species may respond differently due to hydrological and to physiological differences among plants. Here we test this hypothesis.Methods: A

Discovery and Structural Characterization of a Phospholamban-Binding Cyclic Peptide and Design of Novel Inhibitors of Phospholamban

The interplay between cardiac sarcoplasmic Ca2+ATPase and phospholamban is a key regulating factor of contraction and relaxation in the cardiac muscle. In heart failure, aberrations in the inhibition of sarcoplasmic Ca2+ATPase by phospholamban are associated with anomalies in cardiac functions. In experimental heart failure models, modulation of the interaction between these two proteins has been

Test Time Analysis for IEEE P1687

The IEEE P1687 (IJTAG) standard proposal aims at providing a standardized interface between on-chip embedded logic (instruments), such as scan-chains and temperature sensors, and the IEEE 1149.1 standard which provides test data transport and test protocol for board test. A key feature in P1687 is to include Select Instrument Bits (SIBs) in the scan path to allow flexibility in test architecture d

A study of the performance of risk and vulnerability assessments by Swedish Public Agencies

Risk and vulnerability assessments (RVA) are vital components of the work conducted by public agencies at different levels, as part of the processes for governing and managing risks in the society. In Sweden, public agencies at all levels are required by legislation to perform risk and vulnerability assessments within their respective area of responsibility. The present paper presents a study of h

Highest Vaccine Uptake after School-Based Delivery - A County-Level Evaluation of the Implementation Strategies for HPV Catch-Up Vaccination in Sweden

BACKGROUND: The Swedish school-based vaccination programme offers HPV vaccine to girls born ≥1999 in 5-6th grade. In 2012, all counties introduced free-of-charge catch-up vaccination campaigns targeting girls born 1993-1998. Varying vaccine uptake in the catch-up group by December 2012 suggested that some implementation strategies were more successful than others. In order to inform future vaccina

Measuring mammographic density : comparing a fully automated volumetric assessment versus European radiologists' qualitative classification

OBJECTIVES: Breast Imaging-Reporting and Data System (BI-RADS) mammographic density categories are associated with considerable interobserver variability. Automated methods of measuring volumetric breast density may reduce variability and be valuable in risk and mammographic screening stratification. Our objective was to assess agreement of mammographic density by a volumetric method with the radi

Geometry and physics of pseudodifferential operators on manifolds

A review is made of the basic tools used in mathematics to define acalculus for pseudodifferential operators on Riemannian manifolds endowed with aconnection: existence theorem for the function that generalizes the phase; analogueof Taylor’s theorem; torsion and curvature terms in the symbolic calculus; the twokinds of derivative acting on smooth sections of the cotangent bundle of the Riemannianm

Errors in medication history at hospital admission : Prevalence and predicting factors

Background: An accurate medication list at hospital admission is essential for the evaluation and further treatment of patients. The objective of this study was to describe the frequency, type and predictors of errors in medication history, and to evaluate the extent to which standard care corrects these errors.Methods: A descriptive study was carried out in two medical wards in a Swedish hospital

Solaris storage ring lattice optimisationwith strong insertion devices

The Solaris synchrotron radiation facility under construction in Krakow will be areplica of the 1.5 GeV storage ring of MAX IV. This compact 3rd generation light source hasbeen designed to have an emittance of 6 nmrad and operate with 500 mA stored current forVUV and and softX-ray production.The lattice consists of 12 doublebend achromats (DBA)where each DBA cell is integrated into one solid iron

Malignancies in Swedish persons with haemophilia : a longitudinal registry study

The aim of the study was to investigate, over time, the incidence of and mortality due to malignant diseases among persons with haemophilia, compared to matched controls. Persons with haemophilia A or B were enrolled via registries at each haemophilia centre, as well as from the National Patient Registry, and were compared to five sex and age-matched controls per patient. Data from the national Ca

Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion

Activated microglial cells are found in the substantia nigra and the striatum of Parkinson's disease patients. These cells have been shown to express catechol-O-methyltransferase activity which may increase during pathological conditions. Lipopolysaccharides are potent activators of microglial cells. After paranigral lipopolysaccharide infusion to rats we observed intense microglial activation aro

Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats

We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities a

The enhanced contractility of the phospholamban-deficient mouse heart persists with aging

Phospholamban ablation in the mouse is associated with significant increases in cardiac contractility. To determine whether this hyperdynamic function persists through the aging process, a longitudinal examination of age-matched phospholamban-deficient and wild-type mice was employed. Kaplan-Meier survival curves indicated no significant differences between phospholamban-deficient and wild-type mi

Binding of Levosimendan, a Calcium Sensitizer, to Cardiac Troponin C

Levosimendan is an inodilatory drug that mediates its cardiac effect by the calcium sensitization of contractile proteins. The target protein of levosimendan is cardiac troponin C (cTnC). In the current work, we have studied the interaction of levosimendan with Ca2+-saturated cTnC by heteronuclear NMR and small angle x-ray scattering. A specific interaction between levosimendan and the Ca2+-loaded

Further evidence for the cardiac troponin C mediated calcium sensitization by levosimendan : Structure-response and binding analysis with analogs of levosimendan

Levosimendan, an inodilatory drag discovered using troponin C as a target protein, has a cardiac effect deriving from the calcium sensitization of contractile proteins. The aim of this study was to give further evidence that levosimendan binds to cardiac troponin C and that the binding involves amino acid residues on helix ε of the N-terminal domain of this calcium-binding protein. Nine organic mo

Phenotype mining in CNV carriers from a population cohort

Phenotype mining is a novel approach for elucidating the genetic basis of complex phenotypic variation. It involves a search of rich phenotype databases for measures correlated with genetic variation, as identified in genome-wide genotyping or sequencing studies. An initial implementation of phenotype mining in a prospective unselected population cohort, the Northern Finland 1966 Birth Cohort (NFB

Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings

Conformations of the regulatory domain of cardiac troponin C (cNTnC) were studied by means of residual dipolar couplings measured from samples dissolved in dilute liquid crystals. Changes in the main chain HN residual dipolar couplings revealed a conformational change in cNTnC due to the complexation with the second binding region (amino acids 148-163) of cardiac troponin I (cTnI). Formation of th