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Ciclosporin to Protect Renal function In Cardiac Surgery (CiPRICS) : A study protocol for a double-blind, randomised, placebo-controlled, proof-of-concept study

Introduction: Acute kidney injury (AKI) after cardiac surgery is common and results in increased morbidity and mortality. One possible mechanism for AKI is ischaemia-reperfusion injury caused by the extracorporeal circulation (ECC), resulting in an opening of the mitochondrial permeability transition pore (mPTP) in the kidneys, which can lead to cell injury or cell death. Ciclosporin may block the

Dust Evolution and the Formation of Planetesimals

The solid content of circumstellar disks is inherited from the interstellar medium: dust particles of at most a micrometer in size. Protoplanetary disks are the environment where these dust grains need to grow at least 13 orders of magnitude in size. Our understanding of this growth process is far from complete, with different physics seemingly posing obstacles to this growth at various stages. Ye

Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation

Accumulating evidence suggests that dysregulated glycerol metabolism contributes to the pathophysiology of obesity and type 2 diabetes. Glycerol efflux from adipocytes is regulated by the aquaglyceroporin AQP7, which is translocated upon hormone stimulation. Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical an

k.p theory of freestanding narrow band gap semiconductor nanowires

We report on a theoretical study of the electronic structures of freestanding nanowires made from narrow band gap semiconductors GaSb, InSb and InAs. The nanowires are described by the eight-band k.p Hamiltonians and the band structures are computed by means of the finite element method in a mixture basis consisting of linear triangular elements inside the nanowires and constrained Hermite triangu

Redox balance in Lactobacillus reuteri DSM20016 : Roles of iron-dependent alcohol dehydrogenases in glucose/glycerol metabolism

Lactobacillus reuteri, a heterofermentative bacterium, metabolizes glycerol via a Pdu (propanediol-utilization) pathway involving dehydration to 3-hydroxypropionaldehyde (3-HPA) followed by reduction to 1,3-propandiol (1,3-PDO) with concomitant generation of an oxidized cofactor, NAD+ that is utilized to maintain cofactor balance required for glucose metabolism and even for oxidation of 3-HPA by a

An Institutional Model for Collaborative Disaster Risk Management in the Southern African Development Community (SADC) Region

This article presents and argues for a collaborative model for disaster risk management in the Southern African Development Community (SADC). The research employed a qualitative study through a literature review and empirical research through focus group interviews to realize its objectives. As a key theory of multinational collaboration, neoliberal institutionalism—a subset of the international r

Plant size affects mutualistic and antagonistic interactions and reproductive success across 21 Brassicaceae species

Plant size has been hypothesized to be a major driver of biotic interactions. However, it is little understood how plant size affects plant mutualists vs. antagonists and the plant's resulting reproductive success. We established a common garden experiment covering an interspecific plant size gradient (from 10 to 130 cm height) across 21 annual Brassicaceae species, thereby standardizing features

An analytic approach to sunset diagrams in chiral perturbation theory : Theory and practice

We demonstrate the use of several code implementations of the Mellin-Barnes method available in the public domain to derive analytic expressions for the sunset diagrams that arise in the two-loop contribution to the pion mass and decay constant in three-flavoured chiral perturbation theory. We also provide results for all possible two mass configurations of the sunset integral, and derive a new on

The economic crisis as a game changer? Exploring the role of social construction in sustainability transitions

Continuing economic turbulence has fuelled debates about social and political reform as much as it has stimulated actions and initiatives aimed at a more fundamental transition of dominant economic systems. This paper takes a transition perspective to explore, from a Western European viewpoint, how the economic crisis is actually viewed through a variety of interpretations and responded to through

Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program

Background-We assessed whether 234 established dyslipidemia-associated loci modify the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid and lipid subfraction levels in the Diabetes Prevention Program randomized controlled trial. Methods and Results-We tested gene treatment interactions in relation to baseline-adjusted follow-up blood lipid concentrations

HvDep1 Is a Positive regulator of culm elongation and grain size in barley and impacts yield in an environment-dependent manner

Heterotrimeric G proteins are intracellular membrane-attached signal transducers involved in various cellular processes in both plants and animals. They consist of three subunits denoted as α, β and γ. The γ-subunits of the so-called AGG3 type, which comprise a transmembrane domain, are exclusively found in plants. In model species, these proteins have been shown to participate in the control of p

Anticipating future risk in social-ecological systems using fuzzy cognitive mapping : The case of wildfire in the Chiquitania, Bolivia

Understanding complex social-ecological systems, and anticipating how they may respond to rapid change, requires an approach that incorporates environmental, social, economic, and policy factors, usually in a context of fragmented data availability. We employed fuzzy cognitive mapping (FCM) to integrate these factors in the assessment of future wildfire risk in the Chiquitania region, Bolivia. In

Using a Game to Engage Stakeholders in Extreme Event Attribution Science

The impacts of weather and climate-related disasters are increasing, and climate change can exacerbate many disasters. Effectively communicating climate risk and integrating science into policy requires scientists and stakeholders to work together. But dialogue between scientists and policymakers can be challenging given the inherently multidimensional nature of the issues at stake when managing c

Statistical Identification of Pleonastic Pronouns

This paper describes an algorithm to identify pleonastic pronouns using statistical techniques. The training step uses a coreference annotated corpus of English and focuses on a set of pronouns such as it. As far as we know, there is no corpus with a pleonastic annotation. The main idea of the algorithm was then to recast the definition of pleonastic pronouns as pronouns that never occur in a core