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Quality and Regulatory Issues Related to Continuous Manufacturing of Biologics

Läkemedelsindustrin är en av de viktigaste aspekterna i det moderna samhället. Denna industri har tillåtit forskare att förbättra människans levnad och ger patienter världen över hopp att deras sjukdomar kan bli behandlade. Läkemedelsindustrin har inte sett så många förändringar när det kommer till produktioner av små molekyler och API under de senaste årtiondena. Men världen förändras. Nya sjukdoIntroduction: Continuous Manufacturing involves the continuous feeding of input materials into the transformation of in-process materials within, and the concomitant removal of output materials from a manufacturing process based on ICH guideline. In these systems, all the processes from raw material to final finished product would be continuously produced. The project aims to: Investigate the chal

Performance of a New Tetra Recart® Package Storing Oxygen Sensitive Food

Tetra Recart® är ett innovativt, kartong-baserat förpackningsalternativ till konserverad mat. Tetra Pak® har sett en ökad efterfrågan på en mindre förpackningsvolym av Tetra Recart®, vilket har gjort att Tetra Recart® utvidgat förpackningsportfolion med en ny, mindre förpackning på 100 mL. Förpackningars dimensioner kan påverka hållbarhetstiden för det förpackade livsmedlet, där mindre förpackningTetra Recart® is an innovative, carton-based packaging alternative for canned foods. Tetra Pak® has seen an increasing demand of a smaller Tetra Recart® package size. Therefore, the Tetra Recart® package family has been extended with a new, smaller package volume of 100 mL. Package dimensions may impact the shelf life of the packed food, where a smaller package (with headspace) is suspected to hav

Comparing different methods of measuring particle size for pharmaceutical excipients

In pharmaceutical science, particle size is one of the most fundamental parameters of materials, but different particle-sizing analysis methods lack a uniform standard for measuring irregular particle size, making it difficult to compare the accuracy and applicability of different particle-sizing analysis methods. Experiments on excipients used in pharmaceuticals are carried out in this paper by l

When climate change hits the vines: a qualitative research on climate adaptation on viticultural practices in Rheingau

Climate change impacts German viticulture through variations in temperature and precipitation patterns. Winegrowing being one of the main socio-economic sectors in Rheingau, implementing adaptation measures is vital to maintain this agricultural practice even in the future. The main focus of this study lies in exploring underlying factors that influence the implementation of climate adaptation mea

Brandteknisk riskvärdering av neonatalintensivvårdsavdelningen på Skånes universitetssjukhus Lund

Denna rapport är en brandteknisk riskvärdering av neonatalintensivvårdsavdelningen på Skånes universitetssjukhus i Lund. Syftet med rapporten är att göra en brandteknisk riskvärdering för att undersöka om personsäkerheten på neo-IVA kan säkerställas vid brand på avdelningen. Patienterna på denna avdelning är för tidigt födda barn som inte överlever utan den livsuppehållande utrustning som finns i This report is a fire safety evaluation of the neonatal intensive care unit at the Skåne University Hospital in Lund. The purpose of the report is to make a fire safety evaluation to investigate whether the personal safety can be ensured in the event of a fire in the ward. The patients in this ward do not survive without their life-sustaining equipment and cannot evacuate their rooms on their own

Hos vem vandrar tankarna? Frekvens av och individuella variationer i mind wandering

Denna studie har ämnat att undersöka relationen mellan mind wandering och personlighet. Tidigare forskning på området har gett en splittrad bild kring uppmätta korrelationer mellan specifika personlighetsdrag och mind wandering. Mind wandering mättes med skalan Mind Wandering Questionnaire och personlighet mättes med Big Five Inventory i en enkät. Fem hypoteser formulerades; mind wandering kommer The present study aimed to investigate the relation between mind wandering and personality. Prior research on the subject has shown varied results on correlations between specific personality traits and mind wandering. Mind wandering frequency was measured using Mind Wandering Questionnaire and personality was measured using Big Five Inventory in the form of a survey. Five hypotheses were formulat

The Rattlin' Bog: The role of cultural values in discourse around peatland use in Ireland

Ireland is reducing its reliance on turf (peat fuel), as draining peatlands for fuel-harvest impacts biodiversity and global warming. Turf-cutting is a historically important practice in Ireland, with many relying on it for fuel and employment. This study examines the role of cultural values in discourse around peatland use in Ireland, to support a Just Transition away from a reliance on peat. Thi

Co-Creation of a Destination's Image: An Exploratory Study of User Practices on Instagram

Today, as anyone could generate content independently, content produced by the Destination Marketing Organisation (DMO) and others co-exist on social media. As such, anyone runs the chance of being a tourism promoter and marketer. Whether this is intentional or not, content generated by the DMOs are not the only thing out there inspiring or influencing tourists' choice of destination, or creat

Skolkuratorers arbete med elever med utländsk bakgrund

The aim of this study is to examine school counselors experiences of working with students with foregin background. Based on school counselors' experiences we wanted to draw attention to the students' social situation and well-being as well as how they view their role and competence in working with these students. Conducting of findings was done with a qualitative approach and through semi

Degenerering - Uppsats om degenereringens innebörd och motverkan

Denna uppsats handlar om degenerering och är ämnad att undersöka vad degenerering innebär och hur man som företag kan förhindra degenerering. I uppsatsen presenteras varumärkes uppkomst, innebörden av degenering och åtgärder innehavaren av ett varumärke kan vidta för att förhindra degenerering. Ett varumärke är något som kan utformas på många olika sätt genom alltifrån tecken till ljud där det vThis thesis is about degeneration of trademarks and is intended to investigate the meaning of degeneration and how you as a company can prevent degeneration. The creation of a trademark, the meaning of degeneration and what the owner of the trademark can do to prevent degeneration is presented during the thesis. A trademark is something that can be designed in several different ways, from words t

Human rights versus the traditional family: Implications of the European Court of Human Rights' standard of review in cases concerning Articles 8 and 12

Against the background of a conservative push against LGBTI+ and women’s rights, in which courts have already become battlefields, it is important to look at how the European Court of Human Rights, a leading human rights adjudicator both in Europe and globally, would respond to arguments made in the name of human rights but whose real purpose is to limit the rights and freedoms of women and LGBTI+

Automated HER2 Scoring of Breast Cancer Tissue using Upconverting Nanoparticle Images

Computer aided pathology is becoming more and more of a requirement within pathology due to increased demand of individualised treatments and personalised medicine. Because of the advance of digital pathology in recent years, where a high resolution camera acquire images of microscope slides, pathologists can now assess tissue samples in digital images. This has enabled automatic assessment of pat

NAG

In this project, I address the difficulties Swedish physicians face in the performance of headache care at primary health care cen- ters. Workflows in the current system have financial, political, communicational, and time-related shortcomings which decrease the possibility to provide equal headache care across the com- plete country. By performing interviews, literature studies, and a human-c

Greening Humanitarian Aid: A case study on environmental mainstreaming in the Minawao Refugee Camp in Cameroon

This thesis is a qualitative case study on greening policies in the Minawao Refugee Camp in far-northern Cameroon. It thoroughly investigates the actors and dynamics of humanitarian aid and specifically explores how environmental mainstreaming can shape humanitarian governance. The case was chosen due to its unique policies and programmes that aim to green the refugee camp and use a participat

Gelling properties of milk gels using rennet as a coagulant

As the consumption of dairy is a common staple in the Nordic and European diet and culture, better understanding of the dairy industry as a whole, and especially the cheese industry is needed to aim for a more sustainable production. This project aims to offer an extended approach on the rennet coagulation of milk, analysing the gelling properties of skim milk samples at different pH values (5.5-6

Utmaningen att orka på sikt - En kvalitativ studie om professionellas emotionella påfrestningar och strategier i arbetet med trauma

Work related stress, including burnout, compassion fatigue and secondary traumatic stress, often occurs in professionals aspiring to support clients with traumatic experiences. The aim of this study was to examine how professional helpers understand and manage their work with clients who have experienced trauma. Examined issues were what challenges the professionals identified in their work, what

Institutional Investors and Sustainability - An Analysis of Institutional Investors’ Legal Due Diligence Obligations

The European Union’s Sustainable Finance Agenda has launched several new actions in order to reorient capital flow of the financial market to sustainability objectives. One of these initiatives was to unify and harmonize the rules on marketing of sustainable aims of financial products. Financial Market Participant, including institutional investors, are obligated to disclose their due diligence po

Interactive approaches for teaching entrepreneurship

Games are not a new method of teaching in education; however, their impact is not well understood in Entrepreneurial Education. These two concepts have been merged in the past with mostly quantitative approaches viewing existing structures. This study contributes to the combination by inductively elaborating on a gamified experience (The Mount Everest Challenge) by presenting the perception of stu

Experimental and computational analysis of the thermal degradation and the loss of strength of engineered wood-based panels

The current trends in the construction industry push toward materials that are more sustainable and environmentally friendlier than more traditional building materials such as concrete and steel. Timber and timber composites are one of the most popular materials on this list, due to both their mechanical strength and pleasant aesthetics. Oriented strand board (OSB) is one of these timber composite

Third Party Benefit and Implications for Input VAT Deduction

Abstract The principle of fiscal neutrality is at the core of the EU VAT system. Neutrality in the EU VAT system comprises of two main elements, that is, equal treatment of taxable persons in the same situation and giving taxable persons the right to deduct input VAT for cost components. The right to deduction is an important element of the VAT system to achieve fiscal neutrality. Deductibility en