The core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers amyloid beta (Aβ42 and Aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for AD, including the early phases of the disease. However, between-center differences in pre-analytical procedures may contribute to variability in measurements across laboratories.

We have developed a technique to measure low-power electromagnetic fields from mm-wave devices non-intrusively by combining a metasurface, designed to absorb power and focus the radiated power in a thermally isolated region, with an infrared camera. The metasurface consists of thermally isolated elements of low mass and highly emissive material for maximal IR conversion of the incident wave. The I

This is a report from the European Society of Gynaecological Oncology State-of-the-Art Virtual Meeting held December 14-16, 2020. The unique 3-day conference offered comprehensive state-of-the-art summaries on the major advances in the treatment of different types of gynecological cancers. Sessions opened with a case presentation followed by a keynote lecture and interactive debates with opinion l

Most of the studies on cutting mechanisms and surface integrity in turning are investigated with a straight tool path (longitudinal/end face turning) while few contributions have been done in curved surface turning. This work explores the evolutions of cutting force, chip morphology and surface integrity when turning a curved surface, using fillet surface machining of AISI 304 stainless steel. The

Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first-line lipid- lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochond

BACKGROUND: Breastfeeding has beneficial effects on numerous health outcomes.OBJECTIVES: We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.METHODS: Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to

The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. Over the past years, AMPK activation has gained increasingattenti

Nätläkare, vårdgivare som tillhandahåller sjukvårdstjänster via smartphoneappar, har gått från att vara perifera inslag i den svenska sjukvården till att på allvar utmana det konventionella sättet att bedriva sjukvård. Den tillgänglighet som nätläkare erbjuder är oöverträffad men alla patientgrupper har inte sett sin tillgång till vård förbättras i samma utsträckning tack vare nätläkare.Syftet medOnline doctor services, healthcare provided via smartphone apps, have gone from being peripheral to seriously challenging the conventional Swedish way of providing healthcare services. The accessibility of online doctors is unsurpassed but all patient groups have not gotten better access to healthcare thanks to online doctors.The aim of this study was to investigate how perceptions of the online d

In the morning hours of April 11, the Natanz nuclear facility in Iran was attacked, allegedly by Israel. The strike came at a sensitive time, as Iran and world powers are discussing Washington’s return to the Joint Comprehensive Plan of Action (JCPOA) and the removal of sanctions. According to Israeli estimates, as the Islamic Republic does not wish to jeopardize a US return to the JCPOA, its resp

Recent reports state that firearm-related violence is increasing in Sweden. In order to understand the trend of firearm-related violence in Sweden with regard to rate, modus operandi (MO) and homicide typology, and for which injuries and causes of death firearm-related violence is responsible, a systematic literature review was conducted. After a thorough search in different databases, a total of

Intimate partner violence against women (IPVAW) is a global public health issue often assumed to be associated with gender inequality. The so-called Nordic Paradox, the apparently contradictory co-existence of high levels of IPVAW and of gender equality in Nordic countries, has not been adequately explained. This study explores discussions about how this apparent paradox can be understood among 30

The genus Eois Hübner (Geometridae: Larentiinae) comprises 254 valid species. Being a hyperdiverse genus, Eois potentially includes many undescribed cryptic species and embodies a problematic taxonomic scenario. The actual diversity of Eois is greatly underestimated and the Neotropical fauna needs to be well known since it figures as one of the most threatened terrestrial ecosystem. In the present

Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p

Existing criteria for inclusion in the European baseline series are summarized. Additional criteria are developed to aid decision making where the current criteria do not yield an unequivocal result. These include a consideration of whether an allergen (hapten) is better placed in a special series and the frequency with which an allergen cross-reacts with existing markers in the baseline series.

In 2009, consistent with its objective to support and develop a European research infrastructure, the European Union (EU) created a neworganizational form for research collaborations: the European Research Infrastructure Consortium (ERIC). Since then, 21 different ERICs havebeen established in the EU Member States; the largest being the European Spallation Source (ESS).The financing of this ERIC i