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Little is known about the expression and function of Retinoic acid-related orphan receptors (RORA, B, and C) in pancreatic β cells. Here in, we utilized cDNA microarray and RNA sequencing approaches to investigate the expression pattern of ROR receptors in normal and diabetic human pancreatic islets. Possible correlations between RORs expression and HbA 1c levels as well as insulin secretory cap
Purpose: The aim of this work was to investigate, in patients with newly diagnosed Graves’ disease (GD), the frequency of islet autoantibodies including autoantibodies against Zink transporter 8 (ZnT8A), as well as to investigate the relation between thyroid autoantibodies, islet autoantibodies and diabetes both before GD diagnosis and at follow-up. Methods: Blood samples from 278 patients with ne
To investigate core resting state networks in SLE patients with and without neuropsychiatric symptoms by examining functional connectivity changes correlating with results of cognitive testing. Structural MRI and resting state-fMRI (rs-fMRI) were performed in 61 female SLE patients (mean age: 36.8 years, range 18.2–52.0 years) and 20 healthy controls (HC) (mean age 36.2 years, range 23.3–52.2 year
Death and severe morbidity attributable to anesthesia are commonly associated with failed difficult airway management. When an airway emergency develops, immediate access to difficult airway equipment is critical for implementation of rescue strategies. Previously, national expert consensus guidelines have provided only limited guidance for the design and setup of a difficult airway trolley. The o
Insect genitalia are important for species identification and taxonomy and are key traits for the evolution of reproductive isolation through their 'lock-And-key mechanism'. Nevertheless, few studies have evaluated intraspecific variation and the impact of seasonal environmental variation on genital morphology. We used geometric morphometric analysis to quantify male genital morphology within and
Purpose: The purpose of this paper is to advance knowledge about the mechanisms behind, and the implications of, varying involvement in digitally enhanced employee-driven innovation (EDI) by studying how a firm integrates a web-based tool in the organization of its EDI process. Design/methodology/approach: Based on a qualitative in-depth interview study with managers and employees at one high-perf
1. Often, closely related insect species feed on different host plant species, and the tremendous diversity of phytophagous insects is therefore attributed to host plant-driven speciation. However, for most taxa, host use information comes from field observations of egg-laying females or feeding caterpillars, which means that the underlying reason for a particular host-affiliation is not easily de
Bladder cancers are biologically and clinically heterogeneous. Recent large-scale transcriptomic profiling studies focusing on life-threatening muscle-invasive cases have demonstrated a small number of molecularly distinct clusters that largely explain their heterogeneity. Similar to breast cancer, these clusters reflect intrinsic urothelial cell-type differentiation programs, including those with
Undersöker hur svenska börsföretags styrelsens aktiviteter och roll i beslutsfattande utvecklats 1994-2008
Bored at work – Auditors and teachers under management by documentsThe aim is to investigate how experiences of work amongst teachers and auditors change as a shift from input control towards action control is implemented through management by documents. The study is based on interviews with auditors and teachers with long professional experience. The result shows that action control of profession
We report on the influence of oxygen partial pressure for the development of surface oxides covering the industrial aluminum alloy standard 6063 at temperatures ranging from room temperature to 500° C. Using an array of synchrotron-based techniques, we followed the change in oxide thickness, chemical composition, and the lateral distribution of alloying elements. The impact of the oxygen chemical
Lead halide perovskites (LHPs) nanocrystals (NCs), owing to their outstanding photophysical properties, have recently emerged as a promising material not only for solar cells but also for lighting and display applications. The photophysical properties of these materials can be further improved by chemical engineering such as cation exchange. Hot carrier (HC) cooling, as one of the key photophysic
Gör en kritisk argumentationsanalys av policydokument inom ehälsa området
Transport of people and freight on-road have a big impact on the total energy use in the world. The majority of these transports is propelled with diesel engines and the reason is simply that the diesel engine is better than the gasoline engine due to lower fuel consumption. But the cost of this is the increase in dangerous nitrogen oxides (NOx). Around 10 000 people dies everyyear due to emission
This study focuses on two central Scandinavian cities – Copenhagen and Stockholm – that are generally thought to be culturally close but have deviated with respect to cycling policies and infrastructure. Based on a survey including inhabitants of Copenhagen (n¼1110) and Stockholm (n¼1191), this study investigated whether cyclists in Copenhagen and Stockholm experience thetransport systems in the t
Shrunken pore syndrome (SPS) is a condition in which estimated glomerular filtration rate (eGFR) based upon cystatin C is lower than eGFR based upon creatinine. It has been associated with increased mortality even in the presence of normal GFR in both a cardiac surgical population and a general population. No systematic studies of the variation in eGFR cystatin C /eGFR creatinine -ratio used fo
Spatial models, such as the Besag, York and Mollie (BYM) model, have long been used in epidemiology and disease mapping. A common research question in these subjects is modelling the number of disease events per region; here the BYM models provides a holistic framework for both covariates and dependencies between regions. We use these tools to assess the relative insurance risk associated with the
Recension av Henrik Berggrens bok "Landet utanför" (2018)
