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In a non-negligible number of patients with metastatic colorectal cancer (mCRC), the peritoneum is the predominant site of dissemination. Cure can be achieved by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), but this procedure is associated with long-term morbidity and high relapse rates. Thus, there is a pressing need for improved therapeutic strategies and co

Wastewater sludge represents an important resource for reuse in agriculture. However, potentially harmful pathogens are a main threat in this context. Thus, the aim of this study was to examine the presence of helminth ova and protozoan cysts in dried sewage sludge samples collected from ten wastewater treatment plants (WWTPs) located in eight governorates in Tunisia. Based on morphological criter

PURPOSE: Fibromyalgia (FM) is a complex pain condition, and exercise is considered the first option of treatment. Few studies have examined the effect of exercise on molecular mechanisms in FM. The aim of this study was to analyze the plasma proteome in women with FM and healthy controls (CON) before and after 15 wk of resistance exercise. This study further investigated whether clinical and exerc

Clinical outcome data of patients discharged after Coronavirus disease 2019 (COVID-19) are limited and no study has evaluated predictors of cardiovascular prognosis in this setting. Our aim was to assess short-term mortality and cardiovascular outcome after hospitalization for COVID-19. A prospective cohort of 296 consecutive patients discharged after COVID-19 from two Italian institutions during

According to the Swedish Enforcement Code a debtor is presumed to be the sole owner of movable property which is possessed jointly with a spouse or domestic partner. In my thesis, I investigate this statutory presumption of ownership from a family law perspective. The applicability of the statutory presumption as well as its legal repercussions are determined by family law. It is therefore surprisAccording to the Swedish Enforcement Code a debtor is presumed to be the sole owner of movable property which is possessed jointly with a spouse or domestic partner. In my thesis, I investigate this statutory presumption of ownership from a family law perspective. The applicability of the statutory presumption as well as its legal repercussions are determined by family law. It is therefore surpris

Today, more than half of the world’s population live in cities, and by mid-century it is predicted that more than two-thirds of the world’s population will live in urban areas. This sees cities at the forefront of sustainability, needing to meet social needs within our ecological boundaries. An overarching guiding roadmap to consider sustainability is the United Nations’ Sustainable Development Go

Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenom

The last few decades have witnessed a fundamental change in the administrative law structures of many states. Through the phenomena labelled globalisation, internationalisation and Europeanisation, the national public bodies have seen partially new legal frameworks for administrative activities, judicial review of decisions and accountability regimes. This is very clear in regard to administrative

Pure hydrocarbons with shape and conjugation properties that can be switched by external stimuli is an intriguing prospect in the design of new responsive materials and single-molecule electronics. Here, we develop an oligomeric [8]annulene-based material that combines a remarkably efficient topological switching upon redox changes with structural simplicity, stability, and straightforward synthes

We have measured the 3d→2p transition x rays of kaonic 3He and 4He atoms using superconducting transition-edge-sensor microcalorimeters with an energy resolution better than 6 eV (FWHM). We determined the energies to be 6224.5±0.4(stat)±0.2(syst) eV and 6463.7±0.3(stat)±0.1(syst) eV, and widths to be 2.5±1.0(stat)±0.4(syst) eV and 1.0±0.6(stat)±0.3(stat) eV, for kaonic 3He and 4He, respectively.

We conduct the first 3D hydrodynamic simulations of oxygen-neon white dwarf-neutron star/black hole mergers (ONe WD-NS/BH mergers). Such mergers constitute a significant fraction, and may even dominate, the inspiral rates of all WD-NS binaries. We post-process our simulations to obtain the nuclear evolution of these systems and couple the results to a supernova spectral synthesis code to obtain th

We model the effects of collisions and close encounters on the stellar populations observed in the Milky Way nuclearstellar cluster (NSC). Our analysis is based on N -body simulations in which the NSC forms by accretion of massivestellar clusters around a supermassive black hole. We attach stellar populations to our N -body particles and follow theevolution of their stars, and the rate of collisio

We investigate the possibility that the Sun could have been born in M67 by carrying out N-body simulations of M67-like clusters in a time-varying Galactic environment, and following the Galactic orbits of stars that escape from them. We find that model clusters that occupy similar orbits to M67 today can be divided up into three groups, which we call hot, depleted, and scattered clusters. Hot clus

We present positivity bounds, derived from the principles of analyticity, unitarity and crossing symmetry, that constrain the low-energy constants of chiral perturbation theory. Bounds are produced for 2, 3 or more flavours in meson-meson scattering with equal meson masses, up to and including next-to-next-to-leading order (NNLO), using the second and higher derivatives of the amplitude. We enhanc

Inspired by the flow description of su(N) colour calculations, we recently showed how to simplify the spinor-helicity formalism (at the algebra level two copies of complexified su(2)) by treating each Weyl spinor as part of a flow line with definite chirality and momentum. This formalism, dubbed the chirality-flow formalism, eliminates all non-trivial algebra from tree-level spinor-helicity calcul

Encapsulating reacting biological or chemical samples in microfluidic droplets has the great advantage over single-phase flows of providing separate reaction compartments. These compartments can be filled in a combinatoric way and prevent the sample from adsorbing to the channel walls. In recent years, small-angle X-ray scattering (SAXS) in combination with microfluidics has evolved as a nanoscale