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Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk NB and applied this protocol to mice with MYCN-amplified NB patient-derived xenografts (PDXs). Genomic and transcriptomic analyses were used to reveal NB chemoresistance mechan

The influence of alcoholism on outcome after evacuation of subdural haematoma

The postoperative course and final outcome after evacuation of subdural haematoma are described in 106 male patients in relation to their alcohol consumption. One-third of the patients were alcohol abusers, drinking at least 60 g of ethanol daily. Despite comparable head trauma, they had a significantly higher incidence of acute subdural haematomas and showed increased postoperative morbidity and

Influence of alcohol intake on postoperative morbidity after hysterectomy

Postoperative morbidity after hysterectomy was prospectively studied in 229 consecutive patients in our departments. The incidence of alcohol abuse (>60 gm of alcohol daily) and social drinking (between 25 and 60 gm of alcohol daily) was 6.5% for each. When compared with the social drinkers and the control group, the alcohol abuse group had significantly more complications (80% vs 27% and 80% vs 1

Ankle fractures and alcoholism. The influence of alcoholism on morbidity after malleolar fractures

The postoperative morbidity after osteosynthesis of malleolar fractures was investigated retrospectively by comparing 90 alcohol abusers with 90 controls. The two groups were selected from 626 male patients and were matched regarding trauma, treatment for cardiovascular, pulmonary and endocrine diseases, age, weight, smoking habits, anaesthesia and duration of surgery. The alcohol abusers develope

Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis

The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Preclinical research relies on xenograft mouse models, but these models preclude the human-specific functional interactions of stem cells with their bone marrow microenvir

Gastrocolic fistulas

Sixteen patients were treated for gastrocolic fistula arising as a complication of peptic ulcer (11 cases), colonic perforation (2), gastric cancer (1), colonic cancer (1) or pancreatitis (1). The predominant symptoms were diarrhoea, weight loss and abdominal pain. Barium meal and barium enema were the most reliable means of diagnosis, and no fistula was gastroscopically demonstrable. A one-stage

Perforated gastric ulcer

A retrospective study is presented of 297 patients operated upon for perforated benign gastric ulcer in Denmark from 1975 to 1984. Male: female ratio was 0.9:1, mean age 64.2 years. The numbers of gastric and prepyloric perforations were almost equal (156:141), but gastric perforations were more frequent in elderly women and prepyloric perforations in younger men. Simple closure was performed in 8

Reflux oesophagitis in heavy drinkers : Effect of ranitidine and alginate/metoclopramide

Of 1, 400 consecutive patients applying to an outpatient clinic for treatment of alcoholism, 477 complained of upper abdominal dyspepsia. After 2 weeks of abstinence, 78 had persisting complaints; of these, 72% had oesophagitis at endoscopy. The 53 patients with oesophagitis as the sole diagnosis were randomized to treatment with either ranitidine or a combination of alginate/antacid chewing table

Erythrocyte Mean Cell Volume—Correlation to Drinking Pattern in Heavy Alcoholics

ABSTRACT. Erythrocyte mean cell volume (MCV) correlates well to alcohol intake in moderate alcoholism, but only about 50% of heavy drinkers have increased MCV. To evaluate the influence of the duration and extent of a drinking episode on MCV, 64 addictive alcoholics were investigated prospectively within two weeks after a drinking period. Their daily alcohol intake was 120–480 g and the actual dri

The zinc level in alcoholics receiving disulfiram treatment

On the basis of the theory that malnutrition leads to zinc deficiency, 36 severe alcohol addicts were investigated in a large clinic for alcoholism in Copenhagen. The serum zinc levels were registered on commencement/recommencement of treatment with disulphiram and one month later. A total of 16 patients completed the entire investigation. All of the participants in the trial were without clinical