The postnatal development of the gastrointestinal (GI) system in mammals is genetically programmed, but is, to an unknown extent, regulated by external factors such as the diet and the gut microflora. These factors can influence the growth of the GI tract, the age-related pattern of appearance of digestive enzymes and the decreased intestinal macromolecular permeability at gut closure, normally ti

Popular Abstract in Swedish Avhandlingen behandlar ett syntetiskt system för en process som liknar den kroppsegna processen för metabolism av aminosyror (transaminering). Avhandlingen behandlar också de fundamentala krafter som ligger bakom inbindningen av olika substrat i enzym. Även detta är studerat genom starkt förenklade modellsystem, bestående av cykliska strukturer uppbyggda av glukosenhetTwo new transamination systems are described. The first example is a dibenzo[a,d]- cycloheptene containing system, designed to accomplish a [1,3]-hydride transfer. Several catalysts have been examined for this purpose. tris-Pentafluorophenyl borane was found to be the most efficient catalyst. The stereochemistry of several closely related dibenzo[a,d]- cycloheptene have also been examined, display

Aqueous solutions of a particular type of the nonionic cellulose derivative ethyl(hydroxyethyl)cellulose (EHEC) may form thermoreversible gels in the presence of ionic surfactants. Low-viscous solutions can be transformed to clear, stiff gels as the temperature is increased. The gelation may occur at temperatures as low as 30-35 °C which could make the systems interesting for applications, e.g. as

Objective: Serine protease inhibitors (serpins), the acute phase reactants and regulators of the proteolytic processing of proteins, have been recognized as potential contributors to the pathogenesis of Alzheimer disease (AD). We measured plasma and CSF levels of serpins in controls and patients with dementia. Methods: Using rocket immunoelectrophoresis, ELISA, and Luminex xMAP technology, we anal

According to Jon Elster, mechanisms are frequently occurring and easily recognizable causal patterns that are triggered under generally unknown conditions or with indeterminate consequences. In the absence of laws, moreover, mechanisms provide explanations. In this paper I argue that Elster’s view has difficulties with progressing knowledge. Normally, filling in the causal picture without revising

Popular Abstract in Swedish I avhandlingen presenteras en teori om social makt, baserad på nya utvecklingar inom fältet social ontologi. Jag argumenterar för att en begreppsanalys av social makt kan berikas genom att dra nytta av resultaten inom social ontologi, men även att detta fält kan berikas, och faktiskt kräver, en analys av maktbegreppet. Social makt beror på existensen av andra sociala fThis work presents an account of social power based on recent advances in social ontology. It is argued that a conceptual analysis of social power can be informed by developments in social ontology, but also that this field can be enriched, and in fact requires, an analysis of this central social concept. Social power is dependent on the existence of various kinds of social phenomena, such as ins

Popular Abstract in Swedish Ett av dagens stora miljöproblem är de höga halter av koldioxid som ackumuleras i atmosfären. En stor del av samhällets koldioxidutsläpp kommer från förbränning av fossila bränslen som kol, olja eller bensin. Ett av de mest lovande alternativa bränslen som kan ersätta dagens stora bensinförbrukning är bioetanol. Cellulosainnehållande restprodukter från skogsbruk (t.ex. Ethanol produced from cellulose is a promising future alternative fuel. The production process has three main steps: (i) pretreatment of raw material to increase degradability; (ii) enzymatic hydrolysis of cellulose to produce glucose; (iii) fermentation of glucose into bioethanol. This thesis contains studies with the aim to improve the enzymatic hydrolysis of cellulose from steam pretreated spru

Popular Abstract in Swedish Nya möjligheter att förutsäga sjukdomsutvecklingen vid tidig ledgångsreumatism. I denna avhandling presenteras resultaten från sex studier av patienter med tidig reumatoid artrit (RA) – ledgångsreumatism. Syftet med avhandlingen var att i det tidiga sjukdomsskedet, så snart som möjligt efter diagnos, försöka skaffa information om hur sjukdomen kommer att utvecklas - om Objective: To investigate the role of magnetic resonance imaging (MRI), assessment of bone mineral density (BMD) and antibodies to citrullinated proteins (anti-CCP) in predicting radiologic outcome in patients with early rheumatoid arthritis (RA). Patients: All patients were included in the BARFOT programme (baseline). The patients had rheumatoid arthritis of recent onset with mean disease duratio

The article analyses the narrative structures in which the Holocaust has been situated in Russian historical culture.