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We developed an automatic algorithm with the purpose to assist pathologists to report Gleason score on malignant prostatic adenocarcinoma specimen. In order to detect and classify the cancerous tissue, a deep convolutional neural network that had been pre-trained on a large set of photographic images was used. A specific aim was to support intuitive interaction with the result, to let pathologists
Regime shifts present a big challenge to traditional strategic asset allocation. This article investigates whether regimebased asset allocation can effectively respond to changes in financial regimes at the portfolio level, in an effort to provide better long-term results than more static approaches can offer. The authors center their regime-based approach around a regime-switching model with time
Objectives: Heterophilic antibodies, such as rheumatoid factor (RF), are known to interfere with enzyme-linked immunosorbent assays (ELISAs). Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF)-α blockers is well established. The aims of this study were to develop a protocol for blocking the interaction of present heterophilic antibodies and to validate this procedure by evalu
Objective: To determine the reference interval of fetal scalp blood lactate during second stage of labor. Material: Two hundred and fifty-three women in first stage of labor with a reassuring CTG were asked for permission to sample fetal scalp blood during second stage. Results: In cases with reassuring CTG and five minute Apgar score ≥9, the mean lactate value (±2 SD) was 2.5 mmol/L (lower limit
Summary: Men and women with hip fracture have higher short-term mortality. This study investigated mortality risk over two decades post-fracture; excess mortality remained high in women up to 10 years and in men up to 20 years. Cardiovascular disease (CVD) and pneumonia were leading causes of death with a long-term doubling of risk. Introduction: Hip fractures are associated with increased mortali
The aim of this study was to explore differences and similarities in health care students’ attitudes towards working with and communicating with patients about sexual health issues in their future professions. The aim was also to explore whether the students’ gender, age and future professions were influencing factors and whether there was a change in attitude depending on educational levels, gend
The purpose of this study was to investigate the adhesion properties and tissue reactions in an in vitro model of nanofabricated membranes emulating the vitreous cortex. Electrospinning was performed for either 5, 10 or 15 min to create various thicknesses of poly(ε-caprolactone) (PCL) fibre mats on a poly(glycerol-co-sebacic acid) (PGS) surface. These were fused with adult porcine retinal explant
Registers of quality can be used to ensure that health care recommendations are followed, to verify the logistics of care and serve as a basis for research when population based data are needed. Validation of quality is important and is the fundament of accurate interpretation of collected data. In the present validation of sentinel node biopsy (SN) for malignant melanoma in Southern Sweden during
Objective: The main goal of this research was to assess the seroprevalence of antibodies against measles, rubella, mumps, hepatitis B and all three poliovirus serotypes among children in the Quindio Department, Colombia. Methods: Blood samples were obtained from 170 healthy children aged 5-9 years from nine municipalities in Quindio. The presence of serum IgG antibodies against measles, rubella, m
The seventeen papers were originally discussed in joint seminars in Lund and Nanjing in the beginning of 2014, and presented at a conference in Stockholm in October 2014.
Background: Current prostate cancer screening guidelines conflict with respect to the age at which to initiate screening. Objective: To evaluate the effect of prostate-specific antigen (PSA) screening versus zero screening, starting at age 50-54 yr, on prostate cancer mortality. Design, setting, and participants: This is a population-based cohort study comparing 3479 men aged 50 yr through 54 yr r
We examine strategic self-ignorance—the use of ignorance as an excuse toover-indulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts of such activities. We then confront our model with data from an experiment using prepared, restaurantWe examine strategic self-ignorance—the use of ignorance as an excuse to over-indulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts of such activities. We then confront our model with data from an experiment using prepared, restauran
Background: The development of social assistive robots is an approach with the intention of preventing and detecting falls among seniors. There is a need for a relatively low-cost mobile robot with an arm and a gripper which is small enough to navigate through private homes. Material and methods: User requirements of a social assistive robot were collected using workshops, a questionnaire and inte
This paper investigates a pairwise kidney exchange program that includes patient-donor pairs in which the patients can receive a kidney across the blood group barrier from their own donors. Patients in such pairs gain strictly by an exchange if they are matched to a fully compatible donor. We study the set of priority matchings where the number of patients matched to fully compatible donors is max
Increasing trends of natural organic matter (NOM) in surface water in Nordic countries may cause future problems for drinking water producers. Emerging membrane technology, such as ultrafiltration (UF) and nanofiltration (NF), has the potential to produce safe drinking water of good quality from sources with high organic concentrations. In the present pilot study, surface water from three sources
This paper presents a combinatorial auction which is of particular interest when short completion times are of importance. It is based on a method for approximating the bidders' preferences over two types of items when complementarity between the two may exist. The resulting approximated preference relation is shown to be complete and transitive at any given price vector. It is shown that an appro
Context. Gaia’s very accurate astrometric measurements will allow the optical realisation of the International Celestial Reference System to be improved by a few orders of magnitude. Several sets of quasars are used to define a kinematically stable non-rotating reference frame with the barycentre of the solar system as its origin. Gaia will also observe a large number of galaxies. Although they ar
