The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with no

OBJECTIVES: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previo

In this work, we present a thorough analysis of scalar P -wave χQ0, Q = c, b quarkonia electromagnetic form factors for the γ∗γ∗→ χQ0 couplings, as well as their hadroproduction observables in k⊥-factorisation using the light-front (LF) potential approach for the quarkonium wave function. The electromagnetic form factors are presented as functions of photon virtualities. We discuss the role of the

Reference evapotranspiration (ET0) is one of the most important parameters, which is required in many fields such as hydrological, agricultural, and climatological studies. Therefore, its estimation via reliable and accurate techniques is a necessity. The present study aims to estimate the monthly ET0 time series of six stations located in Iran. To achieve this objective, gene expression programmi

Lakes have an important role in storing water for drinking, producing hydroelectric power, and environmental, agricultural, and industrial uses. In order to optimize the use of lakes, precise prediction of the lake water level (LWL) is a main issue in water resources management. Due to the existence of nonlinear relations, uncertainty, and characteristics of the time series variables, the exact pr

Background and Purpose: Cerebral tissue oxygenation is a critical brain viability parameter, and the magnetic properties of hemoglobin offer the opportunity to noninvasively quantify oxygen extraction fraction (OEF) by magnetic resonance imaging (MRI). Ultrahigh-field MRI shows advantages such as increased sensitivity to magnetic susceptibility differences and improved signal-to-noise ratio that c

A control point for keeping redox homeostasis in Saccharomyces cerevisiae during fermentative growth is the dynamic regulation of transcription for the glycerol-3-phosphate dehydrogenase 2 (GPD2) gene. In this study, the possibility to steer the activity of the GPD2 promoter was investigated by placing it in strains with different ability to reoxidise NADH, and applying different environmental con

We study using in situ transmission electron microscopy the birth of GaAs nanowires from liquid Au-Ga catalysts on amorphous substrates. Lattice-resolved observations of the starting stages of growth are reported here for the first time. It reveals how the initial nanostructure evolves into a nanowire growing in a zincblende 111 or the equivalent wurtzite0001 direction. This growth direction(s) is

Understanding how environmental variation influences even cryptic traits is important to clarify the roles of selection and developmental constraints in past evolutionary divergence and to predict future adaptation under environmental change. Female yellow dung flies (Scathophaga stercoraria) typically have three sperm storage compartments (3S), but occasionally four (4S). More spermathecae are th

Billions of specimens can be found in natural history museum collections around the world, holding potential molecular secrets to be unveiled. Among them are intriguing specimens of rare families of moths that, while represented in morphology-based works, are only beginning to be included in genomic studies: Pseudobistonidae, Sematuridae, and Epicopeiidae. These three families are part of the supe

Alzheimer’s Disease (AD) is a devastating neurodegenerative disease associated with massive neuronal cell death during its pathology. The involvement of the amyloid β 42 (Aβ42) peptideand its role in neurotoxicity is now well established. It is known that the production of oligomers during the aggregation of Aβ42 into highly ordered fibrils is responsible for neuronal cell death. However, the effo

Nature-based Solutions (NbS) are currently promoted as a panacea for improving human-nature relations. Yet the way of amplifying and mainstreaming NbS beyond scientific demonstrator projects into policy contexts is still bearing shortcomings, in particular in the uncertain futures of a post-COVID-19 world. Successful NbS amplification may be achieved by (1) using multi-scalar action to balance dif

Why, in the midst of the global Coronavirus pandemic, do so many people seem resistant to the recommendations of established medical experts? In this chapter, I explore possible structural causes of this resistance in the U.S. context. I argue that in the “post-truth” era, attempts to encourage people to wear face masks and get vaccinated confront challenges pertaining to how scientific knowledge

In this study, we demonstrate an acoustofluidic device that enables single-file focusing of submicron particles and bacteria using a two-dimensional (2D) acoustic standing wave. The device consists of a 100 μm × 100 μm square channel that supports 2D particle focusing in the channel center at an actuation frequency of 7.39 MHz. This higher actuation frequency compared with conventional bulk acoust

In this 20-year anniversary editorial of ephemera, we discuss independent publishing by situating it in a changing academic landscape – one scarred by despair but also leavened by hope. Twenty years ago, the goal of publishing an open access peer-reviewed journal was a radical political gesture in itself. Today, the model of open access publishing has been appropriated, hollowed out, and commodifi

The plastic industry is dependent on fossil fuels in various ways that result in strong “carbon lock-in” throughout the value chain and large and growing CO2 emissions. The industry must decarbonize to reach global net-zero pledges. Although a few initiatives have been launched, they primarily focus on plastic waste. Current research has investigated mitigation potential on different parts of the

Artificial intelligence (AI) has shown promising results in digestive endoscopy, especially in capsule endoscopy (CE). However, some physicians still have some difficulties and fear the advent of this technology. We aimed to evaluate the perceptions and current sentiments toward the use of AI in CE. An online survey questionnaire was sent to an audience of gastroenterologists. In addition, several