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Context: Extracellular nucleotide receptors are expressed in pancreatic B-cells. Purinergic signaling via these receptors may regulate pancreatic B-cell function. Objective: We hypothesized that purinergic signaling might influence glucose regulation and sought evidence in human studies of glycemic variation and a mouse model of purinergic signaling dysfunction. Design: In humans, we mined genome-
Cold sensitivity is a common and persistent complaint after various hand injuries and diseases. The general aim of the thesis was to investigate the consequences of cold sensitivity for daily life in patients with traumatic hand injuries and hand-arm vibration syndrome (HAVS). To obtain a richer and more comprehensive picture reflecting the aim, studies with a quantitative and a qualitative design
Background. Methylmalonic acid (MMA), a sensitive biomarker of functional vitamin B12 deficiency, is commonly determined by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods using manual extraction and derivatization of MMA to reduce polarity prior to separation. Methods. In the present study we introduce a semi-automated extraction o
Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysi
The objective of this study is to reach a better understanding of accidents on Swedish roads involving tractors and to suggest ways of preventing them. In an earlier study we analyzed police-reported fatal accidents and accidents that led to physical injuries from 1992 to 2005. During each year of this period, tractors were involved in 128 traffic accidents on average, an average of 7 people were
We present a study of solvent effects on the zero-point vibrational corrections (ZPVC) to optical rotations and nuclear magnetic resonance shielding constants of solvated molecules. The model used to calculate vibrational corrections rely on an expansion of the potential and property surfaces around an effective molecular geometry and includes both harmonic and anharmonic correction. Numerical exa
We report the signature of an unconventional zwitterion in thick (>40 angstrom) L-cysteine films grown at low temperature (100 K) by means of sublimation in ultrahigh vacuum. Using X-ray photoelectron spectroscopy (XPS) we find that protonated amino groups (57%) are less prevalent than in films grown at higher temperatures. A large majority of the protonated amino groups receive the hydrogen throu
Background: The aim of this study was to examine in elderly men a relationship between depressive symptoms, peripheral vascular disease and cerebral blood flow (CBF). Methods: Population-based cohort study started with an examination of 809 men at age 55, followed by the first (age 68ys) and second follow up (age 82ys). 128 survivors were examined at age 82 with Tc-99m-HMPAO-SPECT to estimate CBF,
According to the Swedish Hernia Register (SHR), the reoperation rate is more than doubled after recurrent groin hernia repair compared with primary repair. The aim was to study the impact of type of mesh repair used in recurrent groin hernia surgery on a 2nd recurrence in a population-based cohort derived from the SHR. All 1st recurrent hernia repairs in the south-west region of Sweden, registered
Objectives: What is the prognostic significance of achieving a systolic blood pressure of <140 mmHg? Setting: Diabetic renal policlinic, university hospital of Lund, Sweden. Subjects: 118 type 2 diabetic patients with micro-macroalbuminuria were followed for four years (range 1-8 years). Method and main outcome measures: The prognostic significance of office, day- and nighttime measurements of blo
Measurements are presented from proton-proton collisions at centre-of-mass energies of root s = 0.9, 2.36 and 7 TeV recorded with the ATLAS detector at the LHC. Events were collected using a single-arm minimum-bias trigger. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the relationship between the mean transverse momentum and charged-particle multi
Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at fo
Abstract in French Cet article examine le rôle et la place des femmes dans les transactions financières d'Ancien Régime, en particulier dans les communautés rurales.
Cathodoluminescence (CL) imaging and spectroscopy are used to study one-dimensional structures from three different decades. Quantum-well wires were fabricated in the 1980s and CL images are presented here, where the individual wires of a 450 nm grating are resolved. V-grooved quantum wires (QWRs) were fabricated in the 1990s and the structures exhibit a number of emission peaks. CL is used to ide
The AuI atom in the title compound, [Au(C21H24N2)(2)](C24H20B5O6), adopts a slightly distorted linear AuC2 coordination geometry arising from its coordination by two mesitylenic N-heterocyclic carbene ligands, forming an overall cationic complex. The dihedral angle between the imidazole rings is 57.3 (6)degrees. In the crystal, the components are linked by weak C-H...O hydrogen bonds.
Objectives: The aim of this study was to investigate the influence of specific components of Andersen's behavioural model on adult individuals' perceived oral treatment need. Methods: A questionnaire was sent to a randomly selected sample of 9,690 individuals, 20 to 89 years old, living in Skane, Sweden. The 58 questions, some with follow-up questions, were answered by 6,123 individuals; a 63% res
Abstract in UndeterminedWe discuss the combination of a hybrid finite element approach and three-dimensional Voronoi-based mesh discretisations for electromechanically coupled problems. The fluxes, i.e. the stresses and electric displacements, are defined within the volume of the polygonal finite elements, whereas the displacements and electric potential are approximated on the boundaries of the e
Carbon deposition has a serious effect on the performance of solid oxide fuel cells (SOFCs). An unsteady-state 2D model based on COMSOL software is used to study the carbon deposition process in a planar SOFC. The carbon deposition, catalyst activity, reaction rate and temperature fields are obtained to analyse the mechanism of carbon deposition in the SOFC at different operating time. The effects
Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. Since galectins have been implicated in mechanisms of both chronic inflammation and cancer, we have inves
This thesis presents models and methods for feedback-based resource management for cyber-physical systems. Common for the scenarios considered are severe resource constraints, uncertain and time-varying conditions and the goal of enabling flexibility in systems design rather than restricting it. A brief survey on reservation-based scheduling, an important enabling technology for this thesis, is pr
