Filetype
Inferring the cell-type composition of bulk samples can provide biological insight. While bulk transcriptomics data has been extensively used for this purpose, the use of proteomics data has remained unexplored until recently. This study evaluates computational approaches for estimating immune cell composition using bulk sample proteomics data. Leveraging defined immune cell populations and simula
Huntington's disease (HD) is a progressive neurodegenerative disorder, and increasing evidence suggests that inflammation, both central and peripheral, plays a role in disease progression. Neurohistology and neuroimaging studies illustrate neuroinflammatory processes as part of HD pathophysiology. Furthermore, studies of blood and cerebrospinal fluid from HD patients show altered levels of inflamm
The imperative to reduce greenhouse gas emissions is intensifying in various sectors. This trend is evident in the non-road mobile machinery sectors, including agricultural and construction equipment, where the electrification of machinery is emerging as a key development. However, battery-electric non-road mobile machinery systems face challenges, primarily due to the limited energy storage capac
Aim: Abiotic environmental conditions shape ecological and evolutionary processes, yet quantifying their influence on organisms remains challenging due to variation among metrics and their intercorrelations. This study evaluates the utility of temporal environmental predictability measures and assesses their explanatory power in phylogenetic comparative analyses. Innovation: We systematically comp
We propose analytical expressions for ultrasound optical tomography and verify them in Monte Carlo simulations. The proposed hybrid analytical-statistical Monte Carlo model enables quantitative reconstruction of up to 5-centimetre deep tissue absorption inhomogeneities.
Ferulic acid (FA) is one of the most abundant hydroxycinnamic acids found in plant cell walls. Its dehydrodimers play an important role in maintaining the structural rigidity of the plant cell wall. Ferulic acid esterases (FAEs) act as debranching enzymes, cleaving the ester bond between FA and the substituted carbohydrate moieties in FA-containing polysaccharides in the plant cell wall. This enzy
We present a method for obtaining an initial-state parton shower model where the (backward) evolution fully consistent with the (forward) evolution of the collinear parton density used. As a proof-of-concept we use parton densities obtained with the parton branching (PB) approach, and modify the default initial-state shower in Pythia8 with this method to be consistent with them. PB is ideally suit
Background/objectives: Being overweight increases the predisposition to obesity and type 2 diabetes (T2D), which significantly elevate stroke risk and the likelihood of severe post-stroke disability. Dietary nitrate (NO3−) supplementation can mitigate obesity and metabolic impairments, making it a promising approach to halt overweight people from developing overt obesity/T2D, thereby potentially a
New extragalactic measurements of the cloud population-averaged star formation efficiency per free-fall time, Ïμff, from PHANGS show little sign of a theoretically predicted dependence on the gas virial level and weak variation with cloud-scale gas velocity dispersion. We explore ways to bring theory into consistency with the observations, particularly by highlighting systematic variations in inte
The inclusion of the knowledge and perspectives of Indigenous peoples and local communities (IPLC) in global sciencepolicy processes are increasingly being mandated. This is indicative of the recognition of their expertise and worldviews to inform social and ecological decisions. The IPBES Values Assessment (VA) explicitly highlighted the necessity for a nuanced engagement of different actors whil
This thesis aims to investigate the novel physics around Majorana bound states (MBSs). MBSs are quasiparticle excitations predicted to exist in topological superconductors. Due to the inherent protection they obtain from their topology, they have long been regarded as a promising setup to build a topologically protected quantum computer. Apart from this very practical application, they continue to
The Majorana tetron is a prototypical topological qubit stemming from the ground-state degeneracy of a superconducting island hosting four Majorana modes. This degeneracy manifests as an effective nonlocal spin degree of freedom, the most paradigmatic signature of which is the topological Kondo effect. Degeneracies of states with different fermionic parities also characterize minimal Kitaev chains
A star’s luminosity increases as it evolves along the main sequence (MS), which inevitably results in a higher surface temperature for planets in orbit around the star. Technologically advanced civilizations may tackle this issue by installing artificial structures – starshades – which can reduce the radiation received by the planet. Starshades, if they exist, are potentially detectable with curre
Herein, it is shown that a fully vertical GaN FinFET can reach close to ideal Baliga's figure of merit (BFOM) for thicker drift layers. Devices with drift layers between 1 and 8 (Formula presented.) are simulated using TCAD, and the device geometry is varied to find optimal device performance. For 8 (Formula presented.) drift layers, device operation at the BFOM limit is found with (Formula presen
Cell type annotation remains a critical bottleneck, with current methods often inaccurate and requiring extensive manual validation, particularly in disease contexts. While large language models (LLMs) show promise, they can be unreliable due to hallucinations. We developed CyteType, a multi-agent framework that generates competing hypotheses grounded in full expression data and study context, val
The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec
Oat grain is a traditional human food that is rich in dietary fibre and contributes to improved human health1,2. Interest in the crop has surged in recent years owing to its use as the basis for plant-based milk analogues3. Oat is an allohexaploid with a large, repeat-rich genome that was shaped by subgenome exchanges over evolutionary timescales4. In contrast to many other cereal species, genomic
Previous versions of this paper were presented at seminars at BI Norwegian Business School and Toulouse School of Economics, and at the ANZESG 2024 meeting in Melbourne. The authors would like to thank all seminar and meeting participants, and in particular Anindya Banerjee (Editor), Jan Ditzen, Eric Gautier, Koen Jochmans, Bonsoo Koo, Adam Lee, Wooyong Lee, Thierry Magnac, Luca Margaritella, Simo
