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Background: The metabolism of amyloid precursor protein (APP) and beta-amyloid (A beta) is widely studied in Alzheimer's disease, where A beta deposition and plaque development are essential components of the pathogenesis. However, the physiological role of amyloid in the adult nervous system remains largely unknown. We have previously found altered cerebral amyloid metabolism in other neuroinflam
The cost efficiency of the biorefining process can be improved by extracting high-molecular-mass hemicelluloses from lignocellulosic biomass prior to ethanol production. These hemicelluloses can be used in several high-value-added applications and are likely to be important raw materials in the future. In this study, steam pretreatment in an alkaline environment was used to pretreat the lignocellu
Study objectives: The aim of this study was to develop quality criteria for further development and use in the Medicines Management(MM) process in European hospitals. Methods: Criteria for MM were developed in three steps using a modified two-stage Delphi-technique. In the first step a literature search was performed and 300 topics were listed. These topics were grouped into three dimensions, e
Background. Giant cell tumor of bone (GCTB) is an aggressive primary osteolytic tumor. GCTB often involves the epiphysis, usually causing substantial pain and functional disability. Denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor. kappa beta ligand (RANKL), is an effective treatment option for patients with advanced GCTB. This analysis of data from an ongo
Det finns en ganska stor samstämmighet bland forskare och också bland många planerare att en rad åtgärder behövs för att transportsystemet skall kunna anpassas till miljömålen. I den här studien har vi undersökt hur olika bebyggelseparametrar påverkar resandet och energianvändningen. Flertalet studier inom området har fokuserat på stora städer. I vår studie har vi analyserat orter i Skåne. Syftet
Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insulin, α-cells are electrically excitable and equipped with dif
This paper contains the discussion inputs by the contributors of the special issue on the subject of rogue waves.
Maternal smoking during pregnancy has been reported to negatively impact sperm counts of the sons. Sufficient data on the effect of paternal smoking is lacking.
The literature on regional innovation systems has considerably enhanced our understanding of the critical role played by geographical proximity and local institutional conditions for the production of new knowledge and its economic exploitation. In most cases, however, both theoretical and empirical work has focused on regional innovation systems situated within a national context. Little research
Laminar burning velocities of four biomass derived gases have been measured at atmospheric pressure over a range of equivalence ratios and hydrogen contents, using the heat flux method on a perforated flat flame burner. The studied gas mixtures include an air-blown gasification gas from an industrial gasification plant, a model gasification gas studied in the literature, and an upgraded landfill g
Background: As more people reach older age, there is a growing interest in improving old person's health, activity, independence and social participation, thereby adding quality to the extended years. Preventive home visits (PHV) programs for old people have received much attention in recent decades. A large body of research shows mixed effects, and argues that a home visit is a complex social pro
We report on the status of the Baltic/Wadden Sea flyway Eider population based on trends in breeding and wintering numbers throughout the region, supplemented by changes in the sex ratio and proportion of young Eiders as monitored in the Danish hunting bag. At the flyway scale, total numbers of breeding pairs decreased by 48% during 2000-2009, after relatively stable breeding numbers in 1991-2000.
Objective: to describe the experiences of immigrant parents of an ultrasound examination in the second trimester of pregnancy, highlighting information, communication, thoughts, feelings and well-being. Methods: An exploratory, qualitative study using in-depth interviews with parents separately. Content analysis was used. A total of nine Farsi-speaking couples, in all 18 persons, who now live in S
Motivated by growing considerations of the scale, severity, and risks associated with human exposure to indoor particulate matter, this work reviewed existing literature to: (i) identify state-of-the-art experimental techniques used for personal exposure assessment; (ii) compare exposure levels reported for domestic/school settings in different countries (excluding exposure to environmental tobacc
