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The need for robust, consistent methods in societal exergy accounting

Studies of societal exergy use have the common aim of tracing the flow of exergy along society, and are used to gain insights into the efficiency of energy use and linkages to economic growth. However, their methodological approaches vary greatly, with significant impacts on results. Therefore, we make a review of past studies to identify, synthesize and discuss methodological differences, to cont

Personuppgifter som betalningsmedel

Personuppgifter som betalningsmedelDen här rapporten visar hur konsumenternas data kommit att få ett centralt värde i den digitala ekonomin. Förändringen väcker frågor om hur väl konsumentskyddet därmed står sig i förhållande till detta. Studien beskriver och analyserar de konsumentrelaterade utmaningar som den växande användningen av personuppgifter som en form av betalningsmedel medför. I studie

Exposure to inorganic arsenic and gene expression in peripheral blood

Arsenic is an established carcinogen and a risk factor for several non-malignant diseases. Mechanisms of arsenic toxicity may include interference with gene expression. The impact of arsenic exposure on gene expression was evaluated in women (n = 80) living in the Puna of the northern Argentinian Andes with varying concentrations (10–1251 μg/L) of arsenic in drinking water. DirectHyb HumanHT-12 v4

Planting to feed the city? : Agricultural production, food security and multi-spatial livelihoods among urban households in Ghana

The 2010 population and housing census in Ghana revealed that more than half of the Ghanaian population lived in urban centers. Critical to the phenomenon of urbanization is the question of how to sustainably feed the urban population especially the urban poor as rapid urbanization has the tendency to urbanize poverty. This has led to renewed policy debate about the implications of farming in citi

Making ‘Smart Meters’ smarter? Insights from a behavioural economics pilot field experiment in Copenhagen, Denmark

This paper examines the relationship between loss aversion and consumer behaviour in a non-price policy intervention that followed the installation of smart meter (SM) technology. Drawing upon insights from behavioural economics, we propose that consumers underestimate potential gains and overestimate potential financial losses resulting from electricity use. To test the hypothesis, we carried out

Biomarkers of microvascular endothelial dysfunction predict incident dementia : a population-based prospective study

BACKGROUND: Cerebral endothelial dysfunction occurs in a spectrum of neurodegenerative diseases. Whether biomarkers of microvascular endothelial dysfunction can predict dementia is largely unknown. We explored the longitudinal association of midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal endothelin-1 (CT-proET-1) and midregional proadrenomedullin (MR-proADM) with dementia and s

On the convergence rate of the Dirichlet-Neumann iteration for unsteady thermal fluid structure interaction

We consider the Dirichlet-Neumann iteration for partitioned simulation of thermal fluid-structure interaction, also called conjugate heat transfer. We analyze its convergence rate for two coupled fully discretized 1D linear heat equations with jumps in the material coefficients across these. These are discretized using implicit Euler in time, a finite element method on one domain, a finite volume

Physiological aspects on intracardiac blood flow

Magnetic resonance imaging enables detailed in vivo study of complex flow through 3D, time-resolved phase contrast imaging (4D flow). 4D flow may reveal previously unknown aspects of the physiology of intracardiac blood flow, and possibly elucidate pathophysiological processes that have yet to manifest themselves outside the heart.The purpose of this thesis is to examine the physiological role of

Supply Chain Risk Management : en idégenerator för hantering av avbrottsrisker i flödeskedjor

I denna publikation presenteras en idégenerator som är avsedd att användas när man letar efter nya alternativ för att hantera företagets avbrottsrisker. Det inledande skedet av sökandet brukar karaktäriseras som ”brainstorming” dvs. det gäller att hitta så många nya riskhanteringsalternativ som möjligt, gärna otraditionella sådana. Här kan idégeneratorn varit till stor hjälp. Den består av 22 olik

Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort : The SABPA study

Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative stress, changes in essential amino acids, and altered coping strategies are correlated with subclinical vascular changes in African (n = 82) and Caucasian (n = 100) men from the

A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate Failure

Objective: To investigate whether the Multi-Biomarker Disease Activity (MBDA) score predicts optimal add-on treatment in patients with early rheumatoid arthritis (RA) who were inadequate responders to MTX (MTX-IRs). Methods: We analyzed data from 157 MTX-IRs (with a Disease Activity Score using the erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Pharmacotherapy (SWEFOT) trial who

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction

The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine res