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Bioactive Pt(II) and Au(I) complexes based on 1,1’-bis(diphenylphosphino)metallocene derivatives

New 1,2,1’ substituted bis(diphenylphoshino)ruthenocenes are described and used as ligands in cis-Pt(II) complexes. The new substances were also employed in Au(I) complexes, together with previously described ferrocene-based ligands. Examples of crystal structures are presented for the ligands, as well as for the platinum and gold complexes. The preliminary biological activity covering antitumour,

Model Reduction of Spatially Distributed Systems Using Coprime Factors and Semidefinite Programming

In this paper an order reduction method for spatially distributed models is presented. Such systems may be modeled as two nodes interacting with each other through feedback. A model of one of the nodes reduced in such a way, that the closed loop performance is approximated. The method exploits a coprime factor description of the closed loop model and semidefinite programming. The method is related