Objectives: Polyamines are organic polycations playing an essential role in cell proliferation and differentiation, as well as in cell contractility, migration and apoptosis. These processes are known to contribute to restenosis, a pathophysiological process often occurring in patients submitted to revascularization procedures. We aimed to test the effect of alpha-difluoromethylornithine (DFMO), a

Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female)

We start with two puzzles: first, how to explain the European Union (EU)'s decline as a climate change leader at the Copenhagen summit? Second, how to understand the partial revival of its leadership position at the Durban climate summit? We advance a twofold explanation, focusing on changes in relative power relations among major powers but also on negotiation strategies and coalition building. I

A method based on hollow-fibre liquid phase microextraction combined with gas chromatography was developed for determination of specific bile acids in caecal materials of rats. Nine unconjugated bile acids, including the primary bile acids (cholic acid, chenodeoxycholic acid and α-muricholic acid) and the secondary bile acids (lithocholic acid, deoxycholic acid, ursodeoxycholic acid, hyodeoxycholi

The review essay compares two different positions on climate geoengineering, providing an overview of the authors' main points and a subsequent analysis of their arguments.

On the basis of a T = 1 icosahedral capsid model, the capsomer-polyion co-assembly process has been investigated by molecular dynamics simulations using capsomers with different net charge and charge distribution as well as linear, branched, and hyper-branched polyions. The assembly process was characterized in terms of the time-dependent cluster size probabilities, averaged cluster size, encapsul

Metformin is a widely used antidiabetic drug associated with the rare side effect of lactic acidosis which has been proposed to be linked to drug-induced mitochondrial dysfunction. Using respirometry, the aim of this study was to evaluate mitochondrial toxicity of metformin to human blood cells in relation to that of phenformin, a biguanide analogue withdrawn in most countries due to a high incide

Core-shell-structured nanoalloy particles with an Al-dominated interior covered by few Yb monolayers have been fabricated using a vapor-aggregation method involving magnetron sputtering. The radially segregated structure of the Yb-Al nanoparticles has been disclosed by "on-the-fly" photoelectron spectroscopy monitoring of the nanoparticle beam in Yb 4f and Al 2p electron binding energy regions. Bo

Saving time to intervention is crucial in patients with symptomatic carotid artery stenosis (SCAS). We introduced a fast-track protocol (FTP). Time frames from the onset of symptoms to intervention before and after the introduction of an FTP were analyzed. SCAS patients (403 patients/405 procedures) were evaluated according to whether surgery was performed before (group 1) or after (group 2) the i

Abstract in UndeterminedUsing longitudinal data this work analyses historical fertility between 1834 and 1914 in an Alpine village situated in north-east Italy, characterised by scarce resources and by an economy which passed from being traditional and based on closed subsistence to becoming open and integrated. During the initial period studied, this territory can be described as a natural fertil

In animals, exposure to certain phthalates negatively affects the male reproductive function. Human results are conflicting and mostly based on subfertile males, in whom the association between exposure and reproductive function may differ from the general population.

The Romanian language lectureship in Trondheim was established on 5th June 2008. This is the date when an agreement was signed between The Institute of the Romanian Language, represented by its director, Mrs. Ionela Dabija, and Norges Teknisk-Naturvitenskapelige Universitet (NTNU) [Norwegian University of Science and Technology], represented by professor Arne Halvorsen, the head of Institutt for m

Background No comprehensive systematic review of the accuracy of glomerular filtration rate (GFR) measurement methods using renal inulin clearance as reference has been published. Study Design Systematic review with meta-analysis of cross-sectional diagnostic studies. Setting & Population Published original studies and systematic reviews in any population. Selection Criteria for Studies Index

This paper discusses processes of emotionalisation and commodification at home and work, a theme that has been a focus of Arlie Hochschild’s research in the USA over the last four decades. What happens when you look at similar processes within another national frame? The American experience is contrasted to that of two periods of rapid cultural and economic change in Swedish society during the ear

The Wenlock Epoch of the Silurian Period has become one of the chronostratigraphically best-constrained intervals of the Paleozoic. The integration of multiple chronostratigraphic tools, such as conodont and graptolite biostratigraphy, sequence stratigraphy, and delta C-13(carb) chemostratigraphy, has greatly improved global chronostratigraphic correlation and portions of the Wenlock can now be co

The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence

Bifacial PV cells have the capacity to produce solar electricity from both sides and, thus, amongst other advantages, allow a significantly increase both in peak and annual power output while utilizing the same amount of silicone. According to the manufacturer, the bifacial cells are around 1.3 times more expensive than the single-sided cells. This way, bifacial PV cells can effectively reduce the

Myocardial perfusion SPECT (MPS) is one of the frequently used methods for quantification of perfusion defects in patients with known or suspected coronary artery disease. This article describes open access software for automated quantification in MPS of stress-induced ischemia and infarction and provides phantom and in vivo validation.