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Introduction: Adenosine is a common pharmacological vasodilator agent used in first pass perfusion MRI as well as nuclear cardiology and echocardiography. Coronary flow reserve (CFR) by adenosine is inhibited by caffeine and therefore caffeine abstinence is routinely proscribed in patients. However, the guidelines differ regarding how long abstinence is needed from 12 to 24 hours. Purpose: This st

The 7Be fragments produced in one-proton removal from relativistic 8B nuclei of 936 MeV/nucleon in a carbon target have been detected in coincidence with γ rays emitted by these fragments at the reaction target. It is found that 13 ± 3% of the 7Be fragments are released in the 429 keV excited state, 7Be*, which gives direct experimental information on the ground state configuration of 8B. The long

One-neutron removal cross-sections (σ-1n) of 17,19C in various targets at about 900 MeV/nucleon, and one-proton removal cross-sections (σ-1p) of 8,10B at about 1400 MeV/nucleon were measured using the fragment separator FRS at GSI. A significant increase of σ-1n for 19C compared to its neighbors was observed. The same behavior was found for σ-1p for the neutron-deficient nucleus 8B compared to the

The technique of intensity interferometry is proposed as a probe of the spatial configuration of two-Neutron haloes. After exploring the sensitivity of interferometry to the n-N configuration, it is demonstrated that the application of the standard method for constructing the correlation function is not valid for halo neutrons. A new iterative method is presented and applied to measurements of the

The longitudinal momentum distribution of Be fragments after fragmentation of B and the one-proton removal cross section (σ-1p) in a carbon target were measured at 1440 MeV/u with the fragment separator FRS used as an energy-loss spectrometer. The results show a narrow momentum distribution with a FWHM value of 91 ± 5 MeV/c and a large cross-section, σ-1p = 98 ± 6 mb. Both these results support th

The fragment separator FRS at GSI was used as an energy-loss spectrometer to study the nuclear structure of exotic light nuclei via nucleon-removal reactions. The measurements performed include the longitudinal momentum distributions of fragments after one-nucleon removal, the one-nucleon removal cross-sections and in some cases the coincident detection of gamma rays emitted from the breakup fragm

The fragment separator FRS at GSI was used as an energy-loss spectrometer to measure the longitudinal momentum distributions of 16,18C fragments after one-neutron removal reactions in 17,19C impinging on a carbon target at about 910 MeV/u. The distributions in the projectile frames are characterized by a FWHM of 141 ± 6 MeV/c for 16C and 69 ± 3 MeV/c for 18C. The results are compared with experime

The excitation functions for elastic α-particle scattering by 12C, 16O, 18O, and 20Ne at 180° in the c.m.s. are determined in wide energy ranges by using the new method of elastic resonance scattering on a thick target in inverse kinematics. In favorable cases, the method makes it possible to reduce considerably the time required for obtaining excitation curves. General regularities observed in th

Fragmentation reactions in a carbon target with beams of 11Li and 14Be at relativistic energies have been studied in a kinematically complete experiment at the ALADIN-LAND setup at GSI. Excited states in 11Li and 14Be were obtained from the data in the inelastic channel. The measured cross sections with the core nucleus in the final state show that in the 14Be case core polarization plays an impor

The chapter focuses on marketing activities of start-up firms. While this is traditionally understood as analyzing the customer needs and how to bridge that gap, for example, through segmentation and branding activities, this chapter has focused on bridging the gaps between industrial actors in order to build networks. The rationale behind this focus relates to the fact that science- and technolog

Protein homeostasis, or proteostasis, is required for mitochondrial function, but its role in cancer is controversial. Here we show that transgenic mice expressing the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) in the prostate develop epithelial hyperplasia and cellular atypia. When examined on a Pten(+/-) background, a common alteration in human prostate cancer, TRAP1 transgenic mi

Cyclophilin D (CypD) is a mitochondrial matrix protein implicated in cell death, but a potential role in bioenergetics is not understood. Here, we show that loss or depletion of CypD in cell lines and mice induces defects in mitochondrial bioenergetics due to impaired fatty acid β-oxidation. In turn, CypD loss triggers a global compensatory shift towards glycolysis, with transcriptional upregulati

BACKGROUND: Small molecule inhibitors of phosphatidylinositol-3 kinase (PI3K) have been developed as molecular therapy for cancer, but their efficacy in the clinic is modest, hampered by resistance mechanisms.METHODS: We studied the effect of PI3K therapy in patient-derived tumor organotypic cultures (from five patient samples), three glioblastoma (GBM) tumor cell lines, and an intracranial model

Background: Depending on the definitions used, between 5 and 20 % of all Swedish children grow up with at least one parent suffering from alcohol problems, while 6 % have at least one parent who has received inpatient psychiatric care, conditions that may affect the children negatively. Nine out of ten Swedish municipalities therefore provide support resources, but less than 2 % of these children

This paper aims to analyze whether patients should be allowed to veto research-related use of medical data collected during routine follow-ups after their withdrawal from first-in-human clinical trials. Forms of withdrawal are identified and it is argued that the right to withdraw might be limited to some of these. The paper concludes that if veto right is denied, then: the research participant sh

PurposeThe location of a logistics facility is strategic decision, impacting distribution cost, efficiency and environmental impact. The purpose of this paper is to systemize existing knowledge by a literature review. Based on the literature review we propose a framework in this area of theoretical and practical relevance.Design/methodology/approachWe have examined the peer-reviewed literature on