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The tumor microenvironment consists of several interacting cell types. Cancer research focssed mainly on the malignant cell in the past. The importance of the tumor microenvironment is increasingly appreciated, as endothelial cells and immune cells were identified as targets for anti-tumor therapy. Targeted therapy against cancer-associated fibroblasts (CAFs) are not in clinical use for the treatm
Value-based pricing is often recommended as superior pricing strategy (e.g. Dolan & Simon, 1996; Hinterhuber, 2008; Liozu et al., 2012; Marn et al., 2004; Monroe, 2003). However, while many studies provide detailed analytical recommendations on how to identify customer value and competitor prices (Forbis & Mehta, 1981; Kortge & Okonkwo, 1993; Marn et al., 2004; Monroe, 2003; Shapiro &a
Although nationalism is an example of a cultural force which in many cases has overruled other, traditional identities and loyalties in nineteenth- and twentieth-century society, the study of nationalism has not been focused very much on the cultural praxis of national identity formation and sharing. As a result, the ideology and politics of nationalism are far better understood than the creation
Smart card data and survey data have different characteristics, which combined have the potential to enrich the total level of information as well as to reduce inherent biases in each dataset. This paper describes a fruitful procedure to use survey data from a smartphone application-based travel survey with prompted recall to validate data from smart card transactions in the same geographical area
An increased use of solar energy is a key ingredient for forging resilient cities. This recognises the importance of the urban fabric being able to use renewable energy sources to become increasingly self-sustainable. In that regard, the integration of active solar energy systems in the built environment will allow cities to reach a high level of sustainability. In this framework, the main objecti
High hyperdiploid childhood acute lymphoblastic leukemia is characterized by multiple chromosomal gains. Recent results show that this subtype harbors relatively few genetic abnormalities besides the extra chromosomes, which appear to arise early and are likely the main driver event. Secondary hits primarily target genes in the rat sarcoma (RAS) signaling pathway and histone modifiers.
Nitrifiers are the slowest growing bacteria used in conventional biological wastewater treatment. Furthermore, their growth rate is seriously hampered by low temperature. As a result, the volume needed for nitrification dominates the volume of the biological reactors at a wastewater treatment plant. As a way of enhancing nitrification and reducing this volume, bioaugmentation can be used. Nitrifie
The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.
Background The role of lower extremity (LE) muscle strength for predicting traumatic knee injury in youth athletes is largely unknown. Aims The aim was to investigate the influence of LE muscle strength on traumatic knee injury in youth female and male athletes. Methods 225 athletes (40% females) from sport senior high schools in Sweden were included in this case-control study. The athletes record
