Klimatet har varit relativt stabilt under den nuvarande interglaciala epoken (Holocen) som inleddes för ungefär 11 700 år sedan. Genom klimatrekonstruktioner från olika geologiska arkiv såsom iskärnor, sjösediment och torvmossar har det ändå påvisats att snabba förändringar i klimatet har inträffat under denna epok. En sådan tidsperiod inträffade för omkring 2800 år sedan och den är intressant ur Geological archives have shown periods of abrupt climate change in the relatively stable Holocene epoch (last ca. 11 700 years). One of these periods was around 2800 cal BP. Several records, mainly from Europe, reveal a shift towards wetter, cooler and windier conditions. There are, however, indications for a global extent of the climate change. The climate change coincides with a distinct increas

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings wi

This paper reports on design studies concerning a moderator concept which aims to maximize the time averaged flux. The idea is to provide neutron spectra showing two clear maxima, with peaks at (similar to 1 angstrom) and (similar to 2.5 angstrom) arising from leakage from both cryogenic and thermal moderators. Such a concept known as a bi-spectral moderator (Mezei, 2006 [1]) while proven on a rea

Texten diskuterar Dalby klosters inflytande över byar, kyrkor och själavård under medeltiden, både i dess närområde och i övriga Skåne och på Bornholm.

We study the Zeeman spin splitting in a quantum point contact (QPC) etched into an InGaAs/InP heterostructure for three orthogonal magnetic field orientations with respect to the QPC. For the two in-plane orientations we observe an isotropic Zeeman spin splitting, which becomes stronger as the system is made more one dimensional. The Lande g factor is enhanced by up to a factor of two compared to

The neuronal endoplasmic reticulum (ER) contributes to many physiological and pathological processes in the brain. A subset of dendritic spines on hippocampal neurons contains ER that may contribute to synapse-specific intracellular signaling. Distribution of ER to spines is dynamic, but knowledge of the regulatory mechanisms is lacking. In live cell imaging experiments we now show that cultured h

Purpose: An increasing incidence and improved prognosis of kidney cancer have led to concern about second primary malignancies. The study of multiple primary malignancies is also important since the association of certain malignancies may guide the search for germline alterations and environmental risk factors. We evaluated bidirectional associations between renal cell carcinoma and other primary

Visualizing and measuring the gas distribution in close proximity to a working catalyst is crucial for understanding how the catalytic activity depends on the structure of the catalyst. However, existing methods are not able to fully determine the gas distribution during a catalytic process. Here we report on how the distribution of a gas during a catalytic reaction can be imaged in situ with high

Background: Socio-economic inequalities in mortality are observed at the country level in both North America and Europe. The purpose of this work is to investigate the contribution of specific risk factors to social inequalities in cause-specific mortality using a large multi-country cohort of Europeans. Methods: A total of 3,456,689 person/years follow-up of the European Prospective Investigation

The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD), compared with age-matched controls.

Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiogra

Measurements of Fourier transform infrared spectroscopy (FTIRS) in the mid-infrared (MIR) region were conducted on sedimentary records from Lake El'gygytgyn, NE Siberia, and Lake Ohrid, Albania/Macedonia. Calibration models relating FTIR spectral information to biogeochemical property concentrations were established using partial least squares regression (PLSR). They showed good statistical perfor

Abstract in UndeterminedA millimeter-wave (mm-wave) impulse radio is an attractive alternative to existing high-speed mm- wave radio systems because of the potential for a simpler transceiver architecture. This paper studies the feasibility of a mm-wave impulse radio system for home and office use by considering state-of-the- art transceivers and multiple-input multiple-output measured propagation

Popular Abstract in Swedish Vi utsätts varje dag för en stor mängd bakterier som skulle kunna göra oss sjuka, men för det mesta håller vi oss ändå friska. Epitelcellerna på hudens yta och på lungornas slemhinna bildar det första försvaret mot sjukdomsframkallande bakterier, dels genom att de utgör en fysisk barriär men också genom att de kan producera små bakteriedödande substanser, så kallade antEvery day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. They can either be constitutively produced or rapidly induced when epithelial

Viruses are considered the simplest form of live. A virus is basically composed of genomic material surrounded by a protecting capsid. Today, full molecular details of many viruses are known, and several subclasses can be discerned. In this review, we present recent advances made over the past few years obtained from theoretical considerations and model simulations to improve our understanding on