Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort stu

The structure of interest is a thin, metallic coating of fcc copper, of thickness down to a few nanometers only, resting on a stiffer substrate. The elastic and plastic properties of the thin coating using nanoindentation under different geometrical features such as size of the indenter and coating thickness are determined. The force-displacement curve is monitored during indentation and the preci

Background: Little is known about how parental gender equality early in their children lives can influence daughters’ decision to use contraceptive pills. Aim:The study aimed at exploring whether maternal working time and paternity leave in Sweden during the first two years of their daughters’ lives is associated with the use of oral contraceptives when they are adolescents or young adults. Materi

After severe acquired brain injury some patients develop a prolonged disorder of consciousness (vegetative state or minimally conscious state), and as such cannot actively participate in neurorehabilitation. However, international opinion and recent research developments emphasize the need for involvement of rehabilitation medicine units in the care of these patients. The article presents recommen

Sphingomyelin (SM) is a sphingolipid present in all eukaryotic cell membranes. Hydrolysis of SM by sphingomyelinase (SMase) generates ceramide, which has effects on cell-cycle regulation and apoptosis. Alkaline sphingomyelinase (Alk-SMase) is the main SM-hydrolysing enzyme in the human intestine, and earlier studies have shown that it has anti-proliferative properties on colon cancer cells, and th

Background: A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their relation to axonal outgrowth after a delayed nerve repair are not well understo

Background: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. The latter

Reinforced concrete is one of the most widely used building materials and if it is properly designed and produced, it is an extremely durable material with a service life up to 100 years. However, under certain environmental conditions the service life of reinforced concrete structures is more limited. Deterioration of concrete structure is in most cases caused by the penetration of aggressive med

Ecology is a leading discipline in the synthesis of diverse knowledge. Ecologists have had considerable experience in bringing together diverse, multinational data sets, disciplines, and cultural perspectives to address a wide range of issues in basic and applied science. Now is the time to build on this foundation and invest in ecological synthesis through new national or international programs.

Objectives: The purpose of this study was to investigate the costs and benefits associated with multisystemic therapy (MST) for conduct disordered youth, 2 years following intake. Methods: The study employed a secondary analysis of 156 youth enrolled in a randomized trial assessing the psychosocial and behavioral outcomes of MST. Results: MST cost on average 105,400 SEK per youth. MST was associat

This paper presents a 3rd-order, 3-bit continuous-time (CT) \Updelta\Upsigma Δ Σ modulator for an LTE radio receiver. A return-to-zero (RZ) pulse, centered in the sampling period by a quadrature clock, is used in the innermost DAC to reduce the sensitivity to loop-delay variations in the modulator, and omit implementing the additional loop delay compensation usually needed in CT modulators. The pe

Objective: Assess the cost effectiveness of budesonide/formoterol (BUD/FORM) Turbuhaler (R) +tiotropium (TIO) HandiHaler (R) vs. placebo (PBO)+TIO in patients with chronic obstructive pulmonary disease (COPD) eligible for inhaled corticosteroids/long-acting beta(2)-agonists (ICS/LABA). Methods: The cost-effectiveness analysis was based on the 12-week, randomised, double-blind CLIMB trial. The stud

Artikeln presenterar kortfattat min forskning om etiska frågor kring nutritionell genomik och dess tillämpning i personaliserad nutrition.

Virtual communities and social networks assume and consume more aspects of people's lives. In these evolving social spaces, the boundaries between actual and virtual reality, between living individuals and their virtual bodies, and between private and public domains are becoming ever more blurred. As a result, users and their presentations of self, as expressed through virtual bodies, are increasi