To realize the potential of microRNAs (miRs) as fine-tuning regulators of embryonic neuronal differentiation, it is critical to define their developmental function. Mmu-miR-134 (miR-134) is a powerful inducer of pluripotent stem cell differentiation. However, its functional role during embryonic, neuronal development is unknown. We demonstrate that mature, miR-134 transcript levels elevate during

Symmetric cells (cathode/electrolyte/cathode) were prepared using BaCe0.2Zr0.7Y0.1O3-delta (BCZY27) as proton conducting electrolyte and LaCoO3 (LC) infiltrated into a porous BCZY27 backbone as cathode. Single phased LC was formed after annealing in air at 600 degrees C for 2 h. Scanning electron micrographs showed the presence of the infiltrated LC in the full cathode depth. Transmission electron

The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes

The abundance of heavy elements (metallicity) in the photospheres of stars similar to the Sun provides a 'fossil' record of the chemical composition of the initial protoplanetary disk. Metal-rich stars are much more likely to harbour gas giant planets(1-4), supporting the model that planets form by accumulation of dust and ice particles(5). Recent ground-based surveys suggest that this correlation

The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally speci

Reformulation strategies for solving Fitch’s paradox of knowability date back to Edgington. Their core assumption is that the formula \ , from which the paradox originates, does not correctly express the intended meaning of the verification thesis , which should concern possible knowledge of actual truths, and therefore the contradiction does not represent a logical refutation of verificationism.

The aim of the study was to illuminate the families' lived experience after completing a child's cancer treatment. The study took place at a University Hospital in southern Sweden. Interviews were carried out with 10 mothers, eight fathers, four patients and two siblings from a total of 10 families. The interviews were analysed with a hermeneutical phenomenological approach. One essential theme em

The present study focuses on how patients diagnosed with psychosis deal with a conflicting situation. In the study, two groups of patients were assessed. One group consisted of patients diagnosed with psychosis (n=41), while the comparison group (n=135) consisted of inpatients diagnosed either with anorexia nervosa or with bulimia nervosa. The groups were assessed using the Serial Color Word Test

Bats are mammals of chief conservation concern and also represent potentially powerful bio-indicators. Surveying bats is thus an important task but the approaches adopted may either be too invasive (capture) or prone to identification errors (acoustic methods). We here report on the use of a photographic trap to survey bat species richness we tested at two drinking sites in central Italy. The spec

Open-cell porous metal foams have received attention for use in compact heat exchangers due to their increasing availability and improved thermal performance. In recent years, considerable research has been conducted on use of metallic and nonmetallic foams to further improve performance of state-of-the-art heat exchangers. In this paper, we report preliminary results from fabrication, development

The purpose of this study was to determine the association between physical activity and self-reported disability in ambulatory persons with mild to moderate late effects of polio (N=81, mean age 67 years). The outcome measures were: Physical Activity and Disability Survey (PADS), a pedometer, Self-reported Impairments in Persons with Late Effects of Polio Scale (SIPP), Walking Impact Scale (Walk-

The national identity of the source culture often constitutes an important hermeneutic frame from which a translated text is understood. At the same time, literary texts themselves sometimes have a tendency to resist cultural narratives and stereotypical ideas of a certain nation. This article explores how such a resistance is made in the English translations of four Swedish novels from the 1930s.

Abstract is not available

According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major chal

Epidemiological studies suggest health-protective effects of flavan-3-ols and their derived compounds on chronic diseases. The present study aimed to estimate dietary flavan-3-ol, proanthocyanidin (PA) and theaflavin intakes, their food sources and potential determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration cohort. Dietary data were collected using

The comparative and combined effects of nitric oxide (NO) and higher alkanes on methane oxidation were examined by experimentation and kinetic modeling. Experiments were conducted using fuel-lean, lower-alkanes mixtures with NO (0-400 ppm v/v) in an atmospheric flow reactor at residence time of 2 s over the temperature range of 820-950 K. NO was found to greatly promote methane conversion, and its

We discuss the climatic and environmental changes during the last millennium in NE Europe based on a ca. 8-m long high-resolved and well-dated marine sediment record from the deepest basin of Gullmar Fjord (SW Sweden). According to the Pb-210- and C-14-datings, the record includes the period of the late Holocene characterised by anomalously cold summers and well-known as the Little Ice Age (LIA).