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Imaging Non-Local Magnetization Dynamics

Many fundamental processes in magnetism take place on a nanometer length and sub-picosecond time scale. An important example of such phenomena in magnetism is ultrafast, spin-polarized transport of laser-excited hot electrons, which is now being recognized as playing a crucial role for novel spintronic devices and for optically induced magnetic switching. Recent experimental examples include the d

Blood chemokine profile in untreated early rheumatoid arthritis : CXCL10 as a disease activity marker

Background: We have recently analyzed the profile of T-cell subtypes based on chemokine receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients compared to healthy controls (HC). Here, we compared the levels of the respective chemokines in blood plasma of ueRA patients with those of HC. We also studied the association of chemokine levels with the proportions of circu

Testing human skin and respiratory sensitizers—what is good enough?

Alternative methods for accurate in vitro assessment of skin and respiratory sensitizers are urgently needed. Sensitization is a complex biological process that cannot be evaluated accurately using single events or biomarkers, since the information content is too restricted in these measurements. On the contrary, if the tremendous information content harbored in DNA/mRNA could be mined, most compl

Understanding Occupation, Sick Leave, and Disability Pension Due to Knee and Hip Osteoarthritis From a Sex Perspective

Objective: To investigate the association between occupation and risk for sick leave or disability pension due to knee or hip osteoarthritis (OA) from a sex perspective. Methods: We conducted a population-based study including residents ages 40–70 years in the Skåne region, Sweden (2007) and working in the included job sectors (n = 165,179). We retrieved data on cause-specific sick leave and disab

Placental pulsatility index : a new, more sensitive parameter for predicting adverse outcome in pregnancies suspected of fetal growth restriction

Introduction: The pulsatility indices of the umbilical and uterine arteries are used as the surrogate measures of utero-placental perfusion. Combining the two might simplify the evaluation of total placental vascular impedance, possibly improve prediction of adverse outcomes, and help identify pregnancies with suspected fetal growth restriction that need more intense surveillance. Material and met

Imaging biomarkers of dementia : recommended visual rating scales with teaching cases

Abstract: The diagnostic work up of dementia may benefit from structured reporting of CT and/or MRI and the use of standardised visual rating scales. We advocate a more widespread use of standardised scales as part of the workflow in clinical and research evaluation of dementia. We propose routine clinical use of rating scales for medial temporal atrophy (MTA), global cortical atrophy (GCA) and wh

Comparing electricity transitions : A historical analysis of nuclear, wind and solar power in Germany and Japan

This paper contributes to understanding national variations in using low-carbon electricity sources by comparing the evolution of nuclear, wind and solar power in Germany and Japan. It develops and applies a framework for analyzing low-carbon electricity transitions based on interplay of techno-economic, political and socio-technical processes. We explain why in the 1970s–1980s, the energy paths o

Projecting Lifetime Risk of Symptomatic Knee Osteoarthritis and Total Knee Replacement in Individuals Sustaining a Complete Anterior Cruciate Ligament Tear in Early Adulthood

Objective: To estimate the lifetime risk of knee osteoarthritis (OA) and total knee replacement (TKR) in persons sustaining anterior cruciate ligament (ACL) tear by age 25 years. Methods: We used the Osteoarthritis Policy Model to project the cumulative incidence of symptomatic knee OA requiring TKR in varying situations: no prevalent or incident injury; isolated ACL tear, surgically treated; isol

Challenges in the industrial implementation of generative design systems : An exploratory study

The aim of this paper is to investigate the challenges associated with the industrial implementation of generative design systems. Though many studies have been aimed at validating either the technical feasibility or the usefulness of generative design systems, there is, however, a lack of research on the practical implementation and adaptation in industry. To that end, this paper presents two cas

Large-diameter single dowel joint : finite element modelling of a reinforced joint

Finding new efficient connectors or improving existing ones are important issues in timber construction. This research investigates an innovative large-diameter dowel-type connection by using a finite elements model calibrated with experimental results. This connection is made of a large-diameter single dowel reinforced by means of a steel plate with a vulcanised rubber layer. The steel plate shap

Effect of cutting edge radius on surface roughness and tool wear in hard turning of AISI 52100 steel

Performance of cutting tool in hard turning is significantly influenced by its microgeometry, such as edge radius. This study presents an experimental exploration to understand the effect of cutting edge radius on machining performance in terms of surface roughness and tool wear. The cutting tools (CBN) with three groups of nominal edge radius, 20, 30, and 40 μm, were used in the study. The cuttin

Assessment of radiographers' competences from the perspectives of radiographers and radiologists : A cross-sectional survey in Lithuania

Background: Assessing radiographers' clinical competence is of major importance in all medical imaging departments, and is a fundamental prerequisite for guaranteeing professional standards in both nursing care and radiography. Despite the fact that self-assessment has been reported to be the most common form of competence evaluation only several studies defining the radiographers' self-assessment

Efficacy versus effectiveness of clinical genetic testing criteria for BRCA1 and BRCA2 hereditary mutations in incident breast cancer

Increasing evidence supports the benefit of identifying BRCA1 and BRCA2 germline mutations in early breast cancer. Selection of patients for genetic testing is based on defined criteria taking individual and family history related factors into account. It is important to make a distinction between efficacy and effectiveness of BRCA testing criteria. Efficacy can be defined as the performance under

Penicillin-susceptible Staphylococcus aureus : susceptibility testing, resistance rates and outcome of infection

Background: Staphylococcus aureus (SA) is an important human pathogen that causes both superficial and invasive infections. Penicillin is now rarely used in the treatment of SA infections due to widespread resistance and a concern about the accuracy of existing methods for penicillin susceptibility testing. The aims of the present study were to determine the frequency of penicillin-susceptible SA

Thomas Piketty and the Rate of Time Preference

Using a standard model where the individual consumption path is computed solving an optimal control problem, we investigate central claims of Piketty (2014) Rather than r>g (confirmed in the data) r-s>g - with s being the rate of time preference - matters. If this condition holds and the elasticity of substitution in the production function is larger than one, the capital share converges to one in