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The effect of clinical features and glucocorticoids on biopsy findings in giant cell arteritis

Background: To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA). Methods: Individuals who developed GCA after inclusion in two population-based health surveys were identified through linkage to the local and the national patient registers. In addition, other patients diagnos

Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures : Evidence for a MAP kinase-dependent mechanism

The regional selectivity and mechanisms underlying the toxicity of the serine/threonine protein phosphatase inhibitor okadaic acid (OA) were investigated in hippocampal slice cultures. Image analysis of propidium iodide-labeled cultures revealed that okadaic acid caused a dose- and time- dependent injury to hippocampal neurons. Pyramidal cells in the CA3 region and granule cells in the dentate gyr

A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens

We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.

Fresh banana pseudo-stems as a tropical lignocellulosic feedstock for methane production

The banana pseudo-stem is a low-lignin-content lignocellulosic biomass that can be used for methane production. In recent years, anaerobic digestion (AD) of dried banana stems for methane production has attracted considerable attention. However, there is limited information regarding methane production from the fresh banana pseudo-stem. The direct usability of fresh banana stems as a resource for

The other side of the coin: the e-government implementation in an Italian municipality

This paper ad to the body of knowledge on the implementation ofthe e-Government and aims to describe how this process was carried out inthe Delta municipality in Northern Italy. This organization is a public organization in an economically important Region and provides services to entrepreneurs such as validation for opening a new business. An interpretativeapproach used with several interviewees

Autonomic influence on atrial fibrillatory process : Head-up and head-down tilting

Background: Changes in the autonomic nervous system (ANS) tone are present before, during, and after episodes of atrial fibrillation (AF). Atrial fibrillatory rate (AFR, the inverse of the atrial cycle length) has been used as a surrogate marker for local refractoriness and is a key characteristic of the fibrillatory process in patients with AF. Aim of this study is to assess changes in AFR, as an

Characterization of total ecosystem-scale biogenic VOC exchange at a Mediterranean oak–hornbeam forest

Recently, the number and amount of biogenically emitted volatile organic compounds (VOCs) has been discussed in great detail. Depending on the ecosystem, the published number varies between a dozen and several hundred compounds. We present ecosystem exchange fluxes from a mixed oak–hornbeam forest in the Po Valley, Italy. The fluxes were measured by a proton transfer reaction-time-of-flight (PTR-T

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index,

Investigation on thermal performance of a high-temperature heat-pipe thermal protection structure

Sharp leading edges with a millimeter-scale radius are required for hypersonic vehicles from aerodynamic reasons. However, with the leading edges being so sharp, stagnation regions at wing and tail leading edges suffer a hostile thermal environment. Therefore, a high-temperature heat pipe is considered to be integrated into the structure of the leading edge to reduce the temperature of the stagnat

Demographic and Seizure Variables, But Not Hypnotizability or Dissociation, Differentiated Psychogenic from Organic Seizures

Early detection and differential diagnosis of psychogenicnon-epileptic seizures (PNES) and epileptic seizures (ES) is a majorclinical issue in comprehensive epilepsy centers. Using blind conditionswith patients with PNES (N = 10) and ES (N = 31) before diagnosis,we tested the hypotheses that individuals with PNES would exhibitsignificantly greater dissociativity, hypnotizability, absorption, and h

The art of gamification; teaching sustainability and system thinking by pervasive game development

In 2013 Hedmark University College conducted a research project where students from a game development project/study program developed and tested a Pervasive Game for learning as part of a class in System Thinking. The overall game goal was to teach Sustainability through System Thinking, and to give the students a real world experience with their game;. It was tested on 5th and 7th graders in ele

Multiple imputation in veterinary epidemiological studies : A case study and simulation

The problem of missing data occurs frequently in veterinary epidemiological studies. Most studies use a complete case (CC) analysis which excludes all observations for which any relevant variable have missing values. Alternative approaches (most notably multiple imputation (MI)) which avoid the exclusion of observations with missing values are now widely available but have been used very little in