Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral organoids that mimic features of developing human brain tissue. These three-dimensional structures provide a unique opportunity to generate cytoarchitecture and cell-cell interactions reminiscent of human brain complexity in a dish. However, current in vitro brain organoid methodologies often result in intra

Most 3d human pose estimation methods assume that input – be it images of a scene collected from one or several viewpoints, or from a video – is given. Consequently, they focus on estimates leveraging prior knowledge and measurement by fusing information spatially and/or temporally, whenever available. In this paper we address the problem of an active observer with freedom to move and explore the

Chemicals is the industrial sector with the highest energy demand, using a substantial share of global fossil energy and emitting increasing amounts of greenhouse gasses following rapid growth over the past 25 years. Emissions associated with energy use have increased with growth in coal-dependent regions but are also commonly underestimated in regions with higher shares of renewable energy. Renew

The strive to create sustainable societies is often addressed through the lens of social, economic-, or environmental sustainability. However, this division fails to acknowledge existential dimensions of sustainability, i.e., the fundamental concern to sustain a good and meaningful life. This paper expands the notion of Existential Sustainability in relation to socio-material dimensions and built The strive to create sustainable societies is often addressed through the lens of social, economic-, or environmental sustainability. However, this division fails to acknowledge existential dimensions of sustainability, i.e., the fundamental concern to sustain a good and meaningful life. This paper expands the notion of Existential Sustainability in relation to socio-material dimensions and built

The development and evaluation of a radioimmunoassay for Nα-triglycyl-lysine8-vasopressin is described. The site of hapten conjugation of the immunogen has been controlled and the use of various radiolabelled tracers has been evaluated with special reference to the site of iodination. The most extensively studied antiserum showed specificity for the N-terminal triglycyl-extension as well as for se

BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect

Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate

Optimizing the benefits versus harms of prostate-specific antigen screening can be achieved through stratifying screening and biopsy. This clinical consultation guide provides the scientific background and evidence-based recommendations.

Objectives: To assess the applicability of the Prostate Cancer Prevention Trial High Grade (Gleason grade ≥ 7) Risk Calculator (PCPTHG) in ten international cohorts, representing a range of populations. Methods: A total of 25,512 biopsies from 10 cohorts (6 European, 1 UK and 3 US) were included; 4 implemented 6-core biopsies, and the remaining had 10 or higher schemes; 8 were screening cohorts, a

Personalized learning tailors material and strategy to student requirements, interests, and goals in e-learning. These developments help educational institutions and other organizations to keep up with the fast pace of information technology, communications, and computing power. Studies show that self-adaptive learning and relevant learning information improve study efficiency. Compared to traditi

Low energy buildings are key to reduce global energy use. However, achieving low energy use and good daylight levels simultaneously in dense cities is challenging. This article reviews relevant studies dealing with energy use and daylighting in dense residential urban blocks located in Nordic climates. The literature review combines a systematic and a ‘snowball’ search approach. Findings indicate

Objective: To validate the hypothesis that men displaying serum prostate-specific antigen (PSA) slopes ≤2.0 pg/mL/mo after prostatectomy, measured using a new immuno-polymerase chain reaction diagnostic test (NADiA ProsVue), have a reduced risk of clinical recurrence as determined by positive biopsy, imaging findings, or death from prostate cancer. Materials and Methods: From 4 clinical sites, we

Resources are a core concept in debates about socio-ecological transformations and post-growth societies, but as a concept they are rarely problematised. Drawing on a resourcification approach in which resources are understood as outcomes of various social processes, this study analyses how resources are conceptualised and understood in degrowth scholarship. Our study shows that resources are seen

The gene encoding human glandular kallikrein (KLK2) was expressed in Escherichia coli, and the corresponding protein (hK2) was produced by fermentation. The hK2 was characterized by Western blotting and epitope map using monoclonal antibodies (MAbs) specific for another protease, prostate- specific antigen (PSA) with high structural identity (80%). MAbs that recognized three different epitopes wer

Background Biomarkers based on detecting prostate cancer (PCa)-specific transcripts in blood are associated with inferior outcomes, but their validation in a clinical context is lacking. Objective To determine whether detecting enhanced transcripts for PCa in whole blood using an analytically valid assay has prognostic significance relative to circulating tumor cell (CTC) enumeration. Design, sett

Structures may collapse during the cooling phase of a fire, yet standard furnace tests only measure the response under heating. There lacks experimental test protocols and design methods to assess resistance until burnout. This paper describes a new experimental approach for burnout resistance evaluation, reports experimental data on loaded reinforced concrete columns in furnace tests with cooling

The 2006 World Health Organization (WHO) growth standard—based on the Multi Growth Reference Study (MGRS)—is a universal standard for healthy height and weight of young children. The share of children that deviate substantially from this growth standard (i.e., fall below −2 standard deviations) defines three important indicators: stunting (low height-for-age), wasting (low weight-for-height), and