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Genome-wide regulatory deterioration impedes adaptive responses to stress in inbred populations of Drosophila melanogaster : inbreeding under stress assessed by RNAseq

Inbreeding depression is often intensified under environmental stress (i.e., inbreeding–stress interaction). Although the fitnessconsequences of this phenomenon are well-described, underlying mechanisms such as an increased expression of deleterious allelesunder stress, or a lower capacity for adaptive responses to stress with inbreeding, have rarely been investigated. We investigated afitness compon

Shouting at the wall : Does negativity drive ideological cross-posting in Brexit Facebook comments?

Using a novel methodological approach to measure emotions in Facebook comments, this Work in Progress (WIP) paper explores the relationship between negative feelings and ideological cross-posting behavior. Using the VoxPopuli data harvester, we collect over 770,000 public Facebook comments1 from the three major political campaign pages active during the Brexit referendum. After sorting users into

Spectacular language and creative marketing in a Singapore tailor shop

A tailor shop located in Singapore’s Chinatown is explored as a case of creative linguistic marketing practice, examining how such practice can be understood in relation to the interaction of local and global forces on the linguistic landscape. The shop uses a range of Scandinavian semiotic resources (language and artefacts) which for us, coming upon the shop, seemed unexpected or, using Sweetland

Spatial Separation of Closely-Located Users in Measured Massive MIMO Channels

We investigate the ability of Massive multiple-input multiple-output (MIMO) systems to spatially separate up to eighteen users located close to one another in line-of-sight (LOS) propagation conditions, in both indoor and outdoor environments. For that, we use fully-synchronous measured channels at 2.6 GHz of single-antenna users moving within a small area and concurrently communicating with a bas

Clinical impact of direct stenting and interaction with thrombus aspiration in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention : Thrombectomy Trialists Collaboration

Aims Preliminary studies suggest that direct stenting (DS) during percutaneous coronary intervention (PCI) may reduce microvascular obstruction and improve clinical outcome. Thrombus aspiration may facilitate DS. We assessed the impact of DS on clinical outcome and myocardial reperfusion and its interaction with thrombus aspiration among ST-segment elevation myocardial infarction (STEMI) patients

Electroweak phase transitions in multi-Higgs models : The case of Trinification-inspired THDSM

The rich vacuum structure of multi-Higgs extensions of the Standard Model (SM) may have interesting cosmological implications for the electroweak phase transition (EWPT). As an important example of such class of models, we consider a particularly simple low-energy SM-like limit of a recently proposed Grand-Unified Trinification model with the scalar sector composed of two Higgs doublets and a comp

Generalized thermodynamics of motility-induced phase separation : Phase equilibria, Laplace pressure, and change of ensembles

Motility-induced phase separation leads to cohesive active matter in the absence of cohesive forces. We present, extend and illustrate a recent generalized thermodynamic formalism which accounts for its binodal curve. Using this formalism, we identify both a generalized surface tension, that controls finite-size corrections to coexisting densities, and generalized forces, that can be used to const

Vitamin D in Graves Disease : Levels, Correlation with Laboratory and Clinical Parameters, and Genetics

Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD.Methods: The levels of vitamin D were compared in 292 patients with newly d

Structure of apoptosis-linked protein ALG-2 : Insights into Ca2+-induced changes in penta-EF-hand proteins

Background: The Ca2+ binding apoptosis-linked gene-2 (ALG-2) protein acts as a proapoptotic factor in a variety of cell lines and is required either downstream or independently of caspases for apoptosis to occur. ALG-2 belongs to the penta-EF-hand (PEF) protein family and has two high-affinity and one low-affinity Ca2+ binding sites. Like other PEF proteins, its N terminus contains a Gly/Pro-rich

The PEF family proteins sorcin and grancalcin interact in vivo and in vitro

The penta-EF hand (PEF) family of calcium binding proteins includes grancalcin, peflin, sorcin, calpain large and small subunits as well as ALG-2. Systematic testing of the heterodimerization abilities of the PEF proteins using the yeast two-hybrid and glutathione S-transferase pull-down assays revealed the new finding that grancalcin interacts strongly with sorcin. In addition, sorcin and grancal

Om normer

Hur vet vi vad som är rätt och fel i en situation? Och hur avgör vi hur vi ska handla? Lagar är tydligt nedskrivna och det finns föreskrivna sanktioner om man bryter mot lagen. Men så tydligt är inte vårt samhälle. När vi är laglydiga utan att känna till lagen följer vi egentligen normer. Vårt handlande styrs sällan enbart av lagar och regler utan av dessa, oskrivna och osynliga, normer.Normer och

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome

The Impact of Inter-Firm Collaborations on SME Internationalisation

Several studies have proposed that small- and medium-sized enterprises (SMEs) lack resources and experiential knowledge to internationalise to distant markets. The authors argue that SMEs can handle the lack of these tangible and intangible internal resources through external collaborations; they can achieve success in international markets by collaborating with business partners. The role of inte

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

BACKGROUND: The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistance. To elucidate the mechanisms responsible for cytarabine resistance, and to create a tool for drug discovery investigations, we established a unique and molecularly reproducible

A platform for phenotypic discovery of therapeutic antibodies and targets applied on Chronic Lymphocytic Leukemia

Development of antibody drugs against novel targets and pathways offers great opportunities to improve current cancer treatment. We here describe a phenotypic discovery platform enabling efficient identification of therapeutic antibody-target combinations. The platform utilizes primary patient cells throughout the discovery process and includes methods for differential phage display cell panning,

Genome-Wide DNA Methylation Profiling of Chronic Lymphocytic Leukemia Subsets Carrying Stereotyped B Cell Receptors

In recent years, subsets of chronic lymphocytic leukemia (CLL) patients carrying quasi-identical or stereotyped B cell receptors (BcRs) have been identified that share clinicobiological features and disease outcome. While these stereotyped subsets show distinct gene expression and genomic profiles, the DNA methylation landscape remains largely unexplored. By applying high-resolution 450K methylati

Search for flavour-changing neutral current top-quark decays t → qZ in proton-proton collisions at √s=13 TeV with the ATLAS detector

A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of s=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t → qZ (q

Measurements of t t . differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in pp collisions at s =13 TeV using the ATLAS detector

Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and tt. system kinematic observables using proton-proton collisions at a center-of-mass energy of s=13 TeV. The data set corresponds to an integrated luminosity of 36.1 fb-1, recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Events with two l