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Medical image segmentation is a critical component in a wide range of clinical applications, enabling the identification and delineation of anatomical structures. This study focuses on segmentation of anatomical structures for 3D printing, virtual surgery planning, and advanced visualization such as virtual or augmented reality. Manual segmentation methods are labor-intensive and can be subjective

Climate change poses a significant global challenge, profoundly affecting species distribution. In recent years, research focusing on the impacts of climate change on freshwater taxa has been relatively limited compared to studies on terrestrial taxa. This study seeks to identify hotspots and occurrences of all Carasobarbus freshwater fish species while also predicting the potential implications o

JavaDL ArtifactJavaDL is a language and toolchain for analyzing Java at the source level. JavaDL is based on MetaDL, a variant of Datalog that adds syntactic pattern matching, here specialized to pattern matching on Java.

Artificial intelligence (AI) is set to disrupt the way businesses and civil society operate, but the large energy usage for training and running AI compute models remains a pressing concern in terms of its sustainability. Analog in-memory computing (AIMC) hardware based on memristor devices is a promising route to significant energy-savings. Among the various memristor technologies, ferroelectric

The Natural Resources Conservation Service Curve Number method (NRCS-CN) is the most widely used approach to estimate runoff from rainfall events. However, some uncertainties in the method remain linked to the value of the standard initial abstraction ratio (λ) and discrepancies between computed and standard tabulated Curve Number (CN) values. Here, we compute CN values and investigate the effects

Clog is a declarative language for describing static code checkers for C. Clog is a dialect of Datalog and adds syntactic pattern matching over the C language. We have built Clog using the MetaDL framework and the Clang C compiler frontend. The MetaDL framework supports Datalog evaluation and syntactic patterns, while the Clang frontend provides AST facts and an AST matching mechanism.We provide t

Background: Observational data on composite scores often comes with missing component information. When a complete-case (CC) analysis of composite scores is unbiased, preferable approaches of dealing with missing component information should also be unbiased and provide a more precise estimate. We assessed the performance of several methods compared to CC analysis in estimating the means of common

Youth are official stakeholders of global environmental politics (GEP) since 1992, and several youth platforms have been created within the framework of the United Nations since the 2000s. However, recently, the oppositional voice of youth, through climate protests, has increased worldwide. While official youth platforms have been active over the years, this article asks to which extent they mitig

We devise an autonomous quantum thermal machine consisting of three pairwise-interacting qubits, two of which are locally coupled to thermal reservoirs. The machine operates autonomously, as it requires no time-coherent control, external driving or quantum bath engineering, and is instead propelled by a chemical potential bias. Under ideal conditions, we show that this out-of-equilibrium system ca

Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activating peptide (PACAP) in migraine prevention, which highlight the importance of targeting peptides, this propo

Lipoproteins, key mediators of lipid transport, facilitate the bidirectional transfer of lipids such as fatty acids, triglycerides, and cholesterol between soluble particles and cell membranes. High-density lipoproteins (HDL) primarily engage in reverse cholesterol transport, while low-density lipoproteins (LDL) predominantly deposit lipids, affecting cardiovascular health with a well-known role i

Background: Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. Methods: We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickn

The identity and source of flexible, semi-transparent, vascular-like components recovered from non-avian dinosaur bone are debated, because: (1) such preservation is not predicted by degradation models; (2) taphonomic mechanisms for this type of preservation are not well defined; and (3) although support for molecular endogeneity has been demonstrated in select specimens, comparable data are lacki

Background and aim. In rural areas, economic and demographic shifts often leave buildings vacant due to functional and locational obsolescence. However, these buildings hold significant value in terms of embodied energy, natural resources, economic capital, and cultural heritage. The real estate sector urgently needs innovative space use strategies and business models to tackle rising vacancy rate

Background and aim.The pandemic accelerated green and digital transition may benefit smaller towns. New opportunities include multi-locational living and working, emerging industries, and novel services to attract creative industries. All these developments entail more freedom for people to choose their place of living. Meanwhile, the real estate sector is in dire need of novel space use concepts

BACKGROUND: Previous studies of glucagon stimulation test (GST) in children have shown variable results regarding the utility and reliability of the cortisol response to this test and its correlation with clinical parameters. The aim of this study was to assess cortisol levels at GST and to evaluate how clinical parameters, such as age, sex, pubertal status and Body Mass Index (BMI), correlate to

This paper discusses how archaeologists might investigate issues of poverty by focusing on poorhouses. The poor and deprived are rarely prominent objects in archaeological research, probably because archaeologists find it difficult to relate to a concept such as poverty. At the same time, there is material culture that can be clearly linked to poverty. One such materiality is poorhouses. While the

BACKGROUND: Risk stratification tools for paediatric community-acquired pneumonia (CAP) in well-resourced settings are scarce. We prospectively developed models to predict CAP severity within a multinational cohort of paediatric emergency departments (EDs). Our primary objective was to develop a risk prediction model to discriminate between mild CAP and moderate or severe CAP to assist clinicians