Analysis of chip formation is one of the most established and informative methods for description of the cutting process. A number of established techniques ranging from optical to electron microscopy have been developed for analysis of continuous chips. Yet, machining of difficult-to-cut materials is accompanied by segmented chip formation. This paper presents an original algorithm based on image

Inconel 718, an efficient superalloy for energy and aerospace applications, is currently machined with cemented carbide tools at low speed (vc≈60 m/min) due to its unfavorable mechanical and thermal properties. The article presents results of superalloy machinability study with uncoated and coated PCBN tools aiming on increased speed and efficiency. Aspects of tool life, tool wear and surface inte

The cytoplasmic protein AXIN1 is involved in the Wnt signalling pathway and its expression is increased in patients with endometriosis compared with healthy controls. The aim of the present cross-sectional study was to further assess the levels of AXIN1 and other inflamma­tory biomarkers in patients with endometriosis. Patients with laparoscopy-verified endometriosis were recruited (n=172) and com

Microarray technology has revolutionized genetic analysis. However, limitations in genome analysis has lead to renewed interest in establishing 'omic' strategies. As we enter the post-genomic era, new microarray technologies are needed to address these new classes of 'omic' targets, such as proteins, as well as lipids and carbohydrates. We have developed a microarray platform that combines self- a

A turbine blade tip with a trapezoidal slot cooling scheme is first proposed in the current paper. The film cooling characteristics of a turbine blade tip with a trapezoidal slot scheme are experimentally studied by the pressure sensitive paint (PSP) technique in transonic flow. Varieties of density ratio, tip clearance gap and position of the trapezoidal slot scheme are selected as investigation

Hip prosthetic loosening is often difficult to detect at an early stage, and there has been uncertainty for a long time as to when the loosening occurs and thus to the basic causes. By comparing different diagnostic methods, we found that loosening is best defined as prosthetic migration and measured by radiostereometric analysis. Convincing evidence indicates that poor interlock, poor bone qualit

A sensitive and rapid enzyme-linked immunosorbent assay for simultaneous quantitation of free and IgA-complexed human protein HC was developed with monoclonal murine antibodies. The total amount of protein HC (free plus IgA-complexed) was measured by a competitive procedure while the protein HC-IgA complex was quantitated by a sandwich enzyme immunoassay. The amount of free protein HC was then obt

Broar över vattendrag utgör viktiga element i många transportsystem. Om broar kollapsar orsakas betydande problem med både direkta och indirekta kostnader för samhällsekonomin. Lokal erosion av botten kring broar är många gånger en huvudorsak till brokollaps, ofta i samband med extrema flödessituationer. Risken för sådan lokal erosion kan bli större i samband med en framtida klimatförändring, vilkBridges are important components in many transportation networks often spanning rivers and other water bodies. The failure of a bridge will cause significant direct and indirect economic losses to society. Scouring of the river bed around bridges is a principal mode of bridge failure typically associated with large floods. The risk of such scour may become higher with the emerging climate change t

Climate change is an increasing threat to sustainable development worldwide. However, the dominant incremental policy approaches have not generated action at anywhere near the rate, scale or depth that is needed. This is largely due to the fact that climate change has historically been framed as a purely external, technical challenge. There is an urgent need for a more integral understanding that

Recent developments in artificial intelligence have generated increasing interest to deploy automated image analysis for diagnostic imaging and large-scale clinical applications. However, inaccuracy from automated methods could lead to incorrect conclusions, diagnoses or even harm to patients. Manual inspection for potential inaccuracies is labor-intensive and time-consuming, hampering progress to

Efficient use of assessment of urine protein excretion in nephrological practice requires adequate reference intervals. To determine the upper reference limits of urine albumin, protein HC (alpha 1-microglobulin, immunoglobulin G (IgG), orosomucoid (alpha 1-acid glycoprotein, alpha 1-antitrypsin, and kappa- and lambda-chain immunoreactivities, the concentrations of these proteins were measured in

We have studied the accuracy of 16 different density functional theory methods to reproduce experimental data for bond lengths, angles, vibrational frequencies, as well as enthalpies and entropies for the binding of N2, H2, CO and hydride ions to various transition-metal complexes (with Fe, Ni, Cr, Mo andW) with relation to nitrogenase.We show that generalized gradient approximation functionals gi

The conversion of technical lignin into valuable chemicals is important for the complete utilization of lignocellulose. The kraft process dominates the pulp industry, and large amounts of kraft lignin are produced worldwide. However, the complexity of lignin limits its valorization. In this study, a kraft lignin, Indulin AT, was depolymerized under base conditions, and the effects of substrate loa

Many research studies have been done to investigate different aspects of environmental challenges. In the product development context, there have been attempts to reduce the environmental impacts of associated activities including the production processes themselves. As a result, various technological improvements have been made and new production processes e.g. powder metallurgy technologies have