As an example of symmetry breaking in NEXAFS spectra of protonated species we present a high resolution NEXAFS spectrum of protonated dinitrogen, the diazynium ion N2H+. By ab initio calculations we show that the spectrum consists of a superposition of two nitrogen 1s absorption spectra, each including a π∗ band, and a nitrogen 1s to H+ charge transfer band followed by a weak irregular progression

SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) inhibitor relative to the widely used, but promiscuous inhibitor Compound C/ Dorsomorphin. Here, we studied the effects of SBI-0206965 on AMPK signalling and metabolic readouts in multiple cell types, including hepa

We present an adaptive Discontinuous Galerkin discretization for the solution of porous media flow problems. The considered flows are immiscible and incompressible. The adaptive approach implemented allows for refinement/coarsening in both the element size and the polynomial degree. The method is evaluated using homogeneous and heterogeneous test cases.

In this paper we present a framework for solving two-phase flow problems in porous media. The discretization is based on a Discontinuous Galerkin method and includes local grid adaptivity and local choice of polynomial degree. The method is implemented using the new Python frontend Dune-FemPy to the open source framework Dune. The code used for the simulations is made available as Jupyter notebook

This paper presents the basic concepts and the module structure of the Distributed and Unified Numerics Environment and reflects on recent developments and general changes that happened since the release of the first DUNE version in 2007 and the main papers describing that state Bastian etal. (2008a, 2008b). This discussion is accompanied with a description of various advanced features, such as co

Oxygen and nitrate availabilities impact the marine nitrogen cycle at a range of spatial and temporal scales. Here, we demonstrate the impact of denitrifying foraminifera on the nitrogen cycle at two oxygen and nitrate contrasting stations in a fjord environment (Gullmar Fjord, Sweden). Denitrification by benthic foraminifera was determined through the combination of specific density counting per

Synaptic pathology is a central event in Alzheimer’s disease (AD) and other neurodegenerative conditions, and investigation of synaptic proteins can provide valuable tools to follow synaptic dysfunction and loss in these diseases. Neuroligin-1 (Nlgn1) is a postsynaptic cell adhesion protein, important for synapse stabilization and formation. Nlgn1 has been connected to cognitive disorders, and spe

In the present work, the laminar burning velocities of the NH3+N2O+air flames were measured using the heat flux method at 1 atm and 298 K, with varied equivalence ratios and N2O mixing ratios. For the mixing ratio N2O/(N2O+air) = 0.5, a full range of equivalence ratios was covered. Moreover, at three equivalence ratios an extended range of mixing ratios was investigated. The laminar burning veloci

A recent literature emphasizes that gender differences in the labor market may in part be driven by a gender gap in willingness to compete. However, whereas experiments in this literature typically investigate willingness to compete in private environments, real world competitions often have a more public nature, which introduces potential social image concerns. If such image concerns are importan

Background: The same dosing schedule, 1000 SQ-U times three, with one-month intervals, have been evaluated in most trials of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis (AR). The present studies evaluated if a dose escalation in ILIT can enhance the clinical and immunological effects, without compromising safety. Methods: Two randomized double-blind placebo-controlle

On 19 August 2015 the European Spallation Source (ESS) was approved by the European Commission as a European Research Infrastructure Consortium (ERIC). The purpose of the contribution is to answer the question about actual VAT treatment of transactions in which ESS is engaged and to make a conclusion whether the current rules contribute to the free movement of knowledge in Europe, also called a "f

BACKGROUND: Sedation practice has evolved from deep to lighter or no sedation in mechanically ventilated patients in the intensive care unit (ICU). The care of conscious intubated patients constitutes a change in the nurse-patient interaction.OBJECTIVE: We aimed to compare the perspectives of expert and competent nurses regarding their interaction with non-sedated mechanically ventilated ICU patie

Background: In egg-laying animals, mothers can influence the developmental environment and thus the phenotype of their offspring by secreting various substances into the egg yolk. In birds, recent studies have demonstrated that different yolk substances can interactively affect offspring phenotype, but the implications of such effects for offspring fitness and phenotype in natural populations have