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Monoclonal antibody production using a new supermacroporous cryogel bioreactor

A supermacroporous cryogel bioreactor has been developed to culture hybridoma cells for long-term continuous production of monoclonal antibodies (mAb). Hybridoma clone M2139, secreting antibodies against J1 epitope (GERGAAGIAGPK; amino acids, 551-564) of collagen type II, are immobilized in the porous bed matrix of a cryogel column (10 mL bed volume). The cells got attached to the matrix within 48

Three-dimensional analysis of the movement of lumbar spinal nerve roots in nonsimulated and simulated adhesive conditions

Study Design. Biomechanical analysis of the movement of the lumbar spinal nerve roots (NRs). Objectives. The characteristics of the movement of lumbar spinal NRs corresponding to the change of posture were three-dimensionally analyzed in nonsimulated and simulated adhesion conditions using a porcine model. Summary of Background Data. There is a paucity of data on the movement of NRs. Materials and

Experiments on elastomechanical wave functions in chaotic plates and their statistical features

We measure the amplitude of the elastomechanical displacement at a fine grid of points on a free plate having the shape of a Sinai stadium. The obtained displacement field formally corresponds to a wave function in a quantum system. While the distribution of the squared amplitudes agrees with the prediction of random matrix theory (RMT), there is a strong deviation of the spatial correlator from t

State of knowledge on measurement and modeling of coastal overwash

A critical review is presented on the state of knowledge and calculation capability for coastal overwash. Overwash and overwash deposits (washover) accompanying hurricanes and severe storms can devastate coastal communities and habitat, but in many areas these processes are essential for maintaining the integrity of barrier islands while creating new habitat. This review covers general studies of

Tracking performance of the transition radiation tracker prototype for the ATLAS experiment

A prototype of the Transition Radiation Tracker (TRT) for the ATLAS experiment at the CERN LHC has been built and tested at the CERN SPS. Detailed studies of the drift-time measurements, alignment technique, hit registration efficiency, track and momentum accuracy were performed. A coordinate measurement accuracy of 150 Pin for a single TRT drift tube and momentum resolution of 0.8% for 20 GeV pio

Effect of hemicellulose and lignin removal on enzymatic hydrolysis of steam pretreated corn stover

Ethanol can be produced from lignocellulosic biomass using steam pretreatment followed by enzymatic hydrolysis and fermentation. The sugar yields, from both hemicellulose and cellulose are critical parameters for an economically-feasible ethanol production process. This study shows that a hear-theoretical glucose yield (96-104%) from acid-catalysed steam pretreated corn stover can be obtained if x

A modeling capacity of vertebral fractures exists during growth - an up to 47-year follow-up

Study Design. The study is an observational cohort study. Objectives. To determine the incidence and the long-term outcome of thoracic or lumbar vertebral fractures in children. Summary of Background Data. The incidence of vertebral fractures in children is described as rare and the outcome as favorable. However, no studies evaluate the clinical and radiographic long-term outcome and if a fracture

Prediction regions for bivariate extreme events

This paper suggests using a mixture of parametric and non-parametric methods to construct prediction regions in bivariate extreme-value problems. The non-parametric part of the technique is used to estimate the dependence function, or copula, and the parametric part is employed to estimate the marginal distributions. A bootstrap calibration argument is suggested for reducing coverage error. This c

MR imaging of spinal intramedullary tumors

The MR examinations in 25 patients with intramedullary tumors were analyzed. Seven patients were diagnosed with astrocytoma, 6 ependymoma, 2 unspecified glioma, 3 medulloblastoma, 2 metastasis, one neurinoma, and one teratoma. In 3 patients the diagnosis was uncertain. The tumors frequently involved a large portion of the cord and were often accompanied by intratumor necrosis, cystic degeneration,

Conservative logarithmic reconstructions and finite volume methods

A class of high-order reconstruction methods based on logarithmic functions is presented. Inspired by Marquina's hyperbolic method, we introduce a double logarithmic ansatz of fifth order of accuracy. Low variation is guaranteed by the ansatz and (slope-) limiting is avoided. The method can reconstruct smooth extrema without order reduction. Fifth order of convergence is verified in a numerical ex

4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study

The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e, 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladde

Antigens for the selection of pan-variable number of tandem repeats motif-specific human antibodies against Mucin-1

Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence

HCCI Combustion - Engine Operation and Emission Characteristics

The potential and limitations of the Homogeneous Charge Compression Ignition (HCCI) engine concept has been experimentally investigated. The operation range, in terms of usable air/fuel ratio and engine load, and the emission characteristics have been studied. An 1.6 litre single cylinder engine based on a heavy duty six cylinder Volvo, was used for the tests. As follows the experimental work was

Particle emission time sequence in intermediate energy heavy ion reactions

The CHIC Collaboration has performed a series of simultaneous pp, np and nn fermion interferometry experiments in order to study the space-time evolution of the emission sources in intermediate energy heavy ion reactions. Furthermore, when correlations of non-identical particles are available, additional model independent information on the emission chronology of the particles is obtained. In this