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Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes

Glioblastoma, a type of cancer affecting the central nervous system, is characterized by its poor prognosis and the dynamic alteration of its metabolic phenotype to fuel development and progression. Critical to cellular metabolism, mitochondria play a pivotal role, where the acetylation of lysine residues on mitochondrial enzymes emerges as a crucial regulatory mechanism of protein function. This

On the derivation of the delta formulation for decision value

This paper contains decision analytical approaches, conditions and models for the quantification of decision values for built environment systems. Specifically, (1) delta formulations of objective functions for decision value quantification are introduced, (2) conditions for decision value are identified and (3) action value analysis formulations are further developed. The delta objective function

Michel ‘Aflaq and the Origins of the Syrian Baathist Party. The ideological construction of a ‘Civil Religion’: 1947-1952.

Michel 'Aflaq, the founder of the Baath Party, has been a revolutionary figure in the Arab world: he was a scholar and philosopher who, with his political vision, inspired an entire generation of young Arab men. He conveyed the nationalist stances towards the formation of a so-called "Civil Religion", namely socialism with Arab ideological ramifications. 'Aflaq played a major role in shaping the p

Resilient Cloud Control System: Dynamic Frequency Adaptation via Q-learning

Traditional control systems face challenges in managing high data loads and computing power, prompting the evolution of Cloud Control Systems (CCS)-a fusion of Networked Control Systems (NCS) and cloud computing. Despite offering manifold advantages, CCS encounters hurdles in navigating the dynamic cloud environment characterized by fluctuating workloads, rendering static frequency settings ineffi

Arab-Islamic predominance in postcolonial Sudan. The seeds of disintegration (1956-1964)

The recent history of Sudan, as is evident from the strict international relevance and the tragic events linked with the birth of South Sudan in July 2011, has been punctuated by an endless series of abuses, inter-ethnic tensions and sectarian conflicts. The multi-ethnic composition and the evident religious disparities among the populations residing in the northern and southern regions of Sudan h

Galectin-8 inhibition and functions in immune response and tumor biology

Galectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pathways. Galectin-8 is a galectin family protein encoded by the LGALS8 gene. Its role is evident in bo

Interplay of halogen bonding and solvation in protein-ligand binding

Halogen bonding is increasingly utilized in efforts to achieve high affinity and selectivity of molecules designed to bind proteins, making it paramount to understand the relationship between structure, dynamics, and thermodynamic driving forces. We present a detailed analysis addressing this problem using a series of protein-ligand complexes involving single halogen substitutions - F, Cl, Br, and

Pore-scale study of two-phase flow in the gas diffusion layer of proton exchange membrane fuel cells : The impact of polytetrafluoroethylene content and gradient distribution

The polytetrafluoroethylene (PTFE) is commonly used to improve the hydrophobic of the gas diffusion layer (GDL). In this study, impacts of PTFE content and piecewise/linear gradient distributions on the transport behavior of liquid water were numerically studied by using a multiphase lattice Boltzmann method. A two-dimensional microstructure of the GDL was reconstructed by stochastic algorithm. Th

Temperature-dependent Study for Hydrogen Crossover in a Polymer Electrolyte Membrane Used in a PEFC

Significance efforts are underway to improve fuel cell performance, with the Polymer Electrolyte Membrane (PEM) being an essential component of Polymer Electrolyte Fuel Cells (PEFCs). The losses within the PEM can be measured through hydrogen crossover. The temperature is a critical variable that directly affects the hydrogen crossover. In this study, the hydrogen crossover and corrected current d

Luxury Fashion and Media Communication : Between the Material and Immaterial

Using image and film advertisements, interviews, social media and public and private archives, Luxury Fashion and Media Communication offers an interdisciplinary approach to analyzing the value of the luxury object. Regular reports on consumption in media and frequent advertising on social media have allowed people all over the world to share in the issues and development of luxury; but how is it

Resilient Cloud Control: Securing, Adapting, and Thriving

This thesis delves into integrating control systems into cloud environments, leading to the emergence of what is commonly referred to as cloud control systems (CCSs). These systems represent a paradigm shift, leveraging the cloud’s expansive storage and computing capabilities to optimize industrial operations. However, while promising in terms of efficiency and scalability, this transition introdu

Stress Testing Control Loops in Cyber-physical Systems

Cyber-physical Systems (CPSs) are often safety-critical and deployed in uncertain environments. Identifying scenarios where CPSs do not comply with requirements is fundamental but difficult due to the multidisciplinary nature of CPSs. We investigate the testing of control-based CPSs, where control and software engineers develop the software collaboratively. Control engineers make design assumption

Metaphors we supervise by

This edited volume aims to bring supervision to life and contribute to a better understanding of the relationship between the supervisor and the thesis-writing student.The authors believe and hope that discussing supervision in terms of metaphors will contribute to a more profound mutual understanding between student and supervisor, a deeper understanding of the context(s) of supervision, reduce f

Show and tell

“Show, don’t tell” is common advice for writers of fiction. This advice is meant to encourage authors to illustrate rather than to directly state information about environments and feelings. For instance, instead of writing “she was angry,” they would write “she left the room with steady steps and slammed the door behind her,” which illustrates anger. When supervising students, I use this advice a

Selling luxury : Sensory labour and communication in the perfume store

In “Selling luxury” perfume and cosmetics stores are approached as mediated physical experiences of luxury. The elusive character of smell has forced perfume brands to invoke guides to explain how their products should be experienced. These guides may be human, in the form of sales assistants, or non-human, in the form of visual marketing materials, packaging and store displays. In the context of