BACKGROUND: Two or more autoantibodies against either insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) or zinc transporter 8 (ZnT8A) denote stage 1 (normoglycemia) or stage 2 (dysglycemia) type 1 diabetes prior to stage 3 type 1 diabetes. Automated multiplex Antibody Detection by Agglutination-PCR (ADAP) assays in two laboratories were compared to single plex radiobinding

The incidence of oropharyngeal cancer (OPC) is increasing in developed countries, and OPC is associated with human papillomavirus infection [1, 2]. Immunotherapies show promise as an end-stage treatment for immune-infiltrated tumours. They are only efficacious in 18% of patients leading to investigation of the immune compartment to comprehend which factors contribute to effective treatments. Anti-

Noun incorporation refers to a linguistic process in which a noun forms a compound with a verb. Globally, the phenomenon is rare, but occurs frequently in several American, Paleo-Siberian and Australian languages. Specifically frequent in Australian languages is the incorporation of body part nouns, a process which has garnered a fair amount of published materials. In Australian languages, incorpo

Aceh is a unique region of Indonesia. In addition to being the site of a nearly three-decade-long conflict between GAM (Gerakan Aceh Merdeka) and the Indonesian state, it is also a special autonomous territory where sharia law is enforced. This political climate has cast a shadow over the province’s multicultural reality, relegating ethnoreligious minorities to a subservient position and restricti

The bone marrow (BM) niche is a complex cellular, molecular, and physical microenvironment capable of homing and supporting hematopoiesis. It is characterized by its ability both maintain and to drive hematopoietic stem and progenitor cells (HSPCs) self-renewal and differentiation which ultimately generate all blood cell types. However, how the niche elements interact in a human context remains la

We examine the change in status of three Swedish colleges to universities in 1999. This change greatly expanded the inflow of resources in the form of basic funding to the new universities. Using detailed individual data, we follow the careers of staff employed before 1999 at the treated institutions, examining their scientific performance, promotion, affiliation, and coauthorship behavior after t

Harnessing the advantages of shared entanglement for sending quantum messages often requires the implementation of complex two-particle entangled measurements. We investigate entanglement advantages in protocols that use only the simplest two-particle measurements, namely, product measurements. For experiments in which only the dimension of the message is known, we show that robust entanglement ad

For many chaperones, a propensity to self-assemble correlates with function. The highly efficient amyloid suppressing chaperone DNAJB6b has been reported to oligomerize. A key question is whether the DNAJB6b self-assemblies or their subunits are active units in the suppression of amyloid formation. Here, we address this question using a nonmodified chaperone. We use the well-established aggregatio

The widespread deployment of digital technologies has made the globe an interconnected world. Among other necessities of the digitalized world, cybersecurity is a crucial component. Therefore, education and proper training of the cybersecurity workforce are essential for building a strong national and global community. However, a significant shortage of proficient cybersecurity experts is reported

The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and distributing essential nutrients and signaling molecules. Emerging evidence suggests a link between glymphatic dysfunction and the pathogenesis of neurode

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from injured sensory neurons as a mechanism contributing to nerve injury-induced pain. Here, we show that intrathecal administration of CSF1, even in the absence of inj

Context:The adoption or acceptance of new technologies or ways of working in software development activities is a recurrent topic in the software engineering literature. The topic has, therefore, been empirically investigated extensively. It is, however, unclear which theoretical frames of reference are used in this research to explain acceptance behaviors.Objective:In this study, we explore how mContext:The adoption or acceptance of new technologies or ways of working in software development activities is a recurrent topic in the software engineering literature. The topic has, therefore, been empirically investigated extensively. It is, however, unclear which theoretical frames of reference are used in this research to explain acceptance behaviors.Objective:In this study, we explore how m

Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relev

Millimeter-wave (mmWave) technology holds the potential to revolutionize head-mounted displays (HMDs) by enabling high-speed wireless communication with nearby processing nodes, where complex video rendering can take place. However, the sparse angular profile of mmWave channels, coupled with the narrow field of view (FoV) of patch-antenna arrays and frequent HMD rotation, can lead to poor performa

The response by David Goldsmith to our recently published Economic Affairs article (Andersson & Jonung, 2024) is puzzling. Most prominently, Goldsmith stresses that the correlation between the stringency of lockdowns and excess death rates is close to zero. This is exactly the main point in our article.