Acquired angioedema due to C1-inhibitor (C1INH) deficiency (AAE) is caused by secondary C1INH deficiency leading to bradykinin-mediated angioedema episodes. AAE typically presents in adulthood and is associated with B cell lymphoproliferation. Anti-C1INH autoantibodies (antiC1INHAbs) are detectable in a subset of AAE cases and considered a hallmark of the disease. When free antiC1INHAbs and malign

Seventeen cases of infections in spinal structures were reported 2010-2017 to the Swedish Health and Social Care Inspectorate (IVO), a government agency responsible for supervising health care, for missed or delayed diagnosis. All patient records were scrutinized in order to find underlying causes and common factors. The delayed diagnoses were equally found among men and women and most frequent in

2014 publicerades Ett forskningsinstitut växer fram – IUI från grundandet till 1950. I den här boken fortsätter historien om Industriens Utredningsinstitut (numera Institutet för Näringslivsforskning). Den period som behandlas är 1950–66, en period då institutet leddes av dynamiska chefer, Jan Wallander (1953–61) och Ragnar Bentzel (1961–66), och dess ställning som Sveriges ledande fristående fors

Den här studien bidrar med sina resultat till kunskapen kring hur kommuner arbetar med krishantering, ett område som tidigare studier visat kräver mer forskning (Choi och Brower, 2006; Marschall, 2015; Jarman et al., 2000; Mullin och Rubado, 2017). Den här studien bidrar även med kunskap kring hur kommuner kan samverka såväl inom den egna organisationen som med andra aktörer över organisatoriska g

In this study we modeled secondary organic aerosol (SOA) mass loadings from the oxidation (by O3, OH and NO3) of five representative biogenic volatile organic compounds (BVOCs): isoprene, endocyclic bond-containing monoterpenes (α-pinene and limonene), exocyclic double-bond compound (β-pinene) and a sesquiterpene (β-caryophyllene). The simulations were designed to replicate an idealized smog chamb

Changes in the latitudinal position and strength of the Southern Hemisphere westerlies (SHW) are thought to be tightly coupled to important climate processes, such as cross-equatorial heat fluxes, Atlantic Meridional Overturning Circulation (AMOC), the bipolar seesaw, Southern Ocean ventilation and atmospheric CO2 levels. However, many uncertainties regarding magnitude, direction, and causes and e

In computer simulations, long-range electrostatic interactions are surprisingly well approximated by truncated, short-ranged pair potentials. Examples are reaction field methods; the Wolf method; and a number of schemes based on cancellation of electric multipole moments inside a cut-off region. These methods are based on the assumption that the polarization of the neglected surroundings can be in

There is an urgent need for society to find more effective ways to reduce the impact of disastrous events. One way is to proactively increase actors’ response capability. Capability assessments play an essential role in these disaster risk management efforts. Currently, capability is assessed using indicator and index methods that focus on available resources. Such methods may not provide the best

Online routing in a planar embedded graph is central to a number of fields and has been studied extensively in the literature. For most planar graphs no O(1)-competitive online routing algorithm exists. A notable exception is the Delaunay triangulation for which Bose and Morin [Bose and Morin, 2004] showed that there exists an online routing algorithm that is O(1)-competitive. However, a Delaunay

I denna studie analyseras förutsättningarna för att bygga energiberedskap i framtida energisystem. Utgångspunkt tas i Energimyndighetens scenarier "Fyra framtider" och de framtidsutvecklingar av energisystemet och samhället i stort som presenteras i dessa. De områden som studeras särskilt i denna rapport är digitalisering, ökad elektrifiering, decentralisering av elproduktionen, ökat beroende av v

Som en följd av det säkerhetspolitiska läget har planeringen för och återuppbyggnaden av ett civilt försvar påbörjats i Sverige. I många sammanhang talar man samtidigt om att Sverige är utsatt för gråzonshot och det förutsätts att det civila försvaret ska kunna hantera dessa hot. Förståelsen för vad dessa hot innebär är dock otillräcklig. I denna rapport introduceras tre områden som bedöms som cen

Background: Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In the case of interleukin-1 (IL-1) inhibition using its receptor antagonist (IL-1Ra), like chondrocytes, synoviocytes also express IL-1 receptors that influence intra-articular IL-1