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Prospective assessment of urinary, gastrointestinal and sexual symptoms before, during and after image-guided volumetric modulated arc therapy for prostate cancer

Objective. The aim of this study was to prospectively assess the development of 24 urinary, gastrointestinal and sexual symptoms in patients with prostate cancer (PCa) during and after image-guided volumetric modulated arc therapy (IG-VMAT). Material and methods. A total of 87 patients with PCa participated in this study. The patients were asked to complete a modified version of the Prostate Cance

Motion management during IMAT treatment of mobile lung tumors - A comparison of MLC tracking and gated delivery

Results: The average gamma index failure rate (2% and 2 mm criteria) was < 0.01% with amplitude gating for all patients, and < 0.1% with phase gating and < 3.7% with MLC tracking for three of the four patients. One of the patients had an average failure rate of 15.1% with phase gating and 18.3% with MLC tracking.With no motion compensation, the average gamma index failure rate ranged from 7.1% to

A generative model for segmentation of tumor and organs-at-risk for radiation therapy planning of glioblastoma patients

We present a fully automated generative method for simultaneous brain tumor and organs-at-risk segmentation in multi-modal magnetic resonance images. The method combines an existing whole-brain segmentation technique with a spatial tumor prior, which uses convolutional restricted Boltzmann machines to model tumor shape. The method is not tuned to any specific imaging protocol and can simultaneousl

A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy : A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking

Purpose A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. Methods and materials Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common mater

Molecular linking selectivity on self-assembled metal-semiconductor nano-hybrid systems

Plasmonics nanoparticles gained prominence in the last decade in fields of photonics, solar energy conversion and catalysis. It has been shown that anchoring the plasmonics nanoparticles on semiconductors via a molecular linker reduces band bending and increases hot carriers’ lifetime, which is essential for the development of efficient photovoltaic devices and photocatalytic systems. Aminobenzoic

Pebble drift and planetesimal formation in protoplanetary discs with embedded planets

Nearly axisymmetric gaps and rings are commonly observed in protoplanetary discs. The leading theory regarding the origin of these patterns is that they are due to dust trapping at the edges of gas gaps induced by the gravitational torques from embedded planets. If the concentration of solids at the gap edges becomes high enough, it could potentially result in planetesimal formation by the streami

Impact of Body Position on Lung Deposition of Nebulized Surfactant in Newborn Piglets on Nasal Continuous Positive Airway Pressure

Introduction: The ideal body position during surfactant nebulization is not known. Objective: The aim of this study was to determine whether body positioning during surfactant nebulization influences surfactant distribution and deposition in the lungs. Methods: Twenty-four 12- to 36-h-old full-termpiglets (1.3-2.2 kg) on nasal continuous positive airway pressure (nCPAP) were randomized into four g

Impaired airway epithelial cell wound-healing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze

Background: Respiratory syncytial virus (RSV) causes exacerbations of asthma and preschool wheeze (PSW). However, the anti-viral and repair responses of the bronchial epithelium in children with severe therapy-resistant asthma (STRA) and PSW are poorly understood. Methods: Children with STRA (age 12 [6-16] years), PSW (age 2 [1-5] years) and non-asthmatic controls (age 7 [2-14] years) underwent br

Selling women the green dream: the paradox of feminism and sustainability in fashion marketing

This article explores the paradox of corporations using social and environmental justice concerns to market products that are themselves made in conditions of environmental and social injustice, most often in the Global South. The effects of the fashion industry on people is two-pronged: 1) the unsafe and exploitative conditions under which many garment workers operate, and 2) the severe and harmf

Behavioral responses of male turnip moths, Agrotis segetum, to sex pheromone in a flight tunnel and in the field

The response of individual male turnip moths Agrotis segetum was observed in a sustained flight tunnel to a mixture of decyl acetate, (Z)-5-decenyl acetate, (Z)-7-dodecenyl acetate, and (Z)-9-tetradecenyl acetate in proportions similar to those found in gland extracts from virgin females (0.6: 1:5:2.5). Lures containing 3-30 μg (Z)-5-decenyl acetate proved to be maximally attractive, with approxim

”Operation Rimfrost bygger, liksom annat polisiärt arbete, på vetenskaplig grund.”

Den ekonomiska brottsligheten må vara högre i områden som Limhamn och Västra hamnen, men det är brott där polisen oftast inte behöver sätta in massiva razzior, skriver Ardavan Khoshnood, docent i akutsjukvård vid Lunds universitet och kriminolog.Economic crime may be higher in areas such as Limhamn and Västra hamnen, but these are crimes where the police usually do not need to launch massive raids, writes Ardavan Khoshnood, associate professor in emergency medicine at Lund University and criminologist.

Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis

Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analys

Nuclear field theory predictions for 11Li and 12Be : Shedding light on the origin of pairing in nuclei

Recent data resulting from studies of two-nucleon transfer reaction on 11Li, analyzed through a unified nuclear-structure-direct-reaction theory have provided strong direct as well as indirect confirmation, through the population of the first excited state of 9Li and of the observation of a strongly quenched ground state transition, of the prediction that phonon-mediated pairing interaction is the

Dyson treatment of NFT medium polarization processes in superfluid nuclei

We discuss the solution of the Dyson equation (also known as the Nambu-Gor'kov equation) for the case of medium polarization Nuclear Field Theory (NFT) processes in nuclei, and apply it to the nucleus 120Sn. Starting from a mean field obtained with the Sly4 effective nucleon-nucleon force, (mk = 0.7), we renormalize the single-particle states and the pairing interaction through the coupling to col

A treatment planning and delivery comparison of volumetric modulated arc therapy with or without flattening filter for gliomas, brain metastases, prostate, head/neck and early stage lung cancer

Background. Flattening filter-free (FFF) beams are an emerging technology that has not yet been widely implemented as standard practice in radiotherapy centers. To facilitate the clinical implementation of FFF, we attempted to elucidate the difference in plan quality and treatment delivery time compared to flattening filter beams (i.e. standard, STD) for several patient groups. We hypothesize that

18F-FDG PET/CT for planning external beam radiotherapy alters therapy in 11% of 581 patients

Background: 18F-FDG PET/CT (FDG PET/CT) used in radiotherapy planning for extra-cerebral malignancy may reveal metastases to distant sites that may affect the choice of therapy. Aim: To investigate the role of FDG PET/CT on treatment strategy changes induced by the use of PET/CT as part of the radiotherapy planning. ‘A major change of treatment strategy’ was defined as either including more lesion

Health impacts from ambient particle exposure in southern sweden

A health impact assessment (HIA) is an important tool for making informed decisions regarding the design and evaluation of environmental interventions. In this study, we performed a quantitative HIA for the population of Scania (1,247,993), the southernmost county in Sweden, in 2016. The impact of annual mean concentrations of particulate matter with an aerodynamic diameter

The Gaia-ESO Survey : An extremely Li-rich giant in globular cluster NGC 1261

Lithium-rich stars in globular clusters are rare. Only 14 have been found so far, in different evolutionary phases from dwarfs to giants. Different mechanisms have been proposed to explain this enhancement, but it is still an open problem. Using spectra collected within the Gaia-ESO Survey, obtained with the GIRAFFE spectrograph at the ESO Very Large Telescope, we present the discovery of the firs