Balcinrenone (AZD9977) is a selective mineralocorticoid receptor modulator in development in combination with dapagliflozin for treatment of heart failure with impaired kidney function and chronic kidney disease. A prespecified concentration–QT analysis was performed based on data from a phase I single ascending dose study prospectively designed as a thorough QT study substitute. Oral single doses

In x-ray photoelectron spectroscopy (XPS), identifying the origin of peaks in the spectrum can be guided by theory calculations. With density functional theory (DFT), using pseudopotentials, one can obtain the difference in photoelectron energy for electrons originating from atoms of different environments, for example surface and bulk atoms, and thus model the surface core level shift (SCLS) ener

In this episode we talk to Georgia De Leeuw about her research on mining, green steel and the comfort alignment with extractivism in in the Swedish north, or indigenous Sápmi. Her PhD dissertation deals with Swedish extractivism in Sápmi through the examples of a planned iron ore mine in Gállok/Kallak and the hydrogen-based steel transition. The main aim is to understand the trust that is placed i

Multidisciplinary team meetings (MDTs) are recommended for patients with esophageal cancer. Improved staging, timeliness to surgery and better adherence to guidelines have been attributed to MDTs, but there are few studies published on the MDTs' effect on survival. All patients with esophageal cancer in Sweden between 2006 and 2018 were grouped according to whether they had been discussed at an MD

The aim of the present European Stroke Organisation (ESO) guideline is to provide evidence-based recommendations on the acute management of patients with basilar artery occlusion (BAO). These guidelines were prepared following the Standard Operational Procedure of the ESO and according to the GRADE methodology. Although BAO accounts for only 1–2% of all strokes, it has very poor natural outcome. W

Introduction Being born with an anorectal malformation (ARM) can have profound and lifelong implications for patients and parents. Organization of care and communication between health care providers is an overlooked area of patient care. The European Reference Network eUROGEN for rare and complex urogenital conditions assembled a panel of experts to address these challenges and develop comprehens

Neutral sodium (Na i) is an alkali metal with a favorable absorption cross section such that tenuous gases are easily illuminated at select transiting exoplanet systems. We examine both the time-averaged and time-series alkali spectral flux individually, over 4 nights at a hot Saturn system on a ∼2.8 day orbit about a Sun-like star WASP-49 A. Very Large Telescope/ESPRESSO observations are analyzed

Models of content-sharing behavior on online social media platforms typically represent content spread as a diffusion process modeled on contagious diseases; users’ behavior is modeled with single-agent decision theory. However, social media platforms are interactive spaces where users care about reactions to, and further spread of, the content they post. Thus, social media interaction falls under

Background and objective: Biparametric magnetic resonance imaging (bpMRI), excluding dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), is a potential replacement for multiparametric MRI (mpMRI) in diagnosing clinically significant prostate cancer (csPCa). An extensive international multireader multicase observer study was conducted to assess the noninferiority of bpMRI to mpMRI in

Standard procedures for entanglement detection assume that experimenters can exactly implement specific quantum measurements. Here, we depart from such idealizations and investigate, in both theory and experiment, the detection of genuine multipartite entanglement when measurements are subject to small imperfections. For arbitrary qubits number n, we construct multipartite entanglement witnesses w

In recent years, an increasing number of ecosystems are threatened by seasonal flooding, changing non-flooded shoreland (NF) into seasonally flooded wetland (SF), but the consequences of this hydrological change for soil organic carbon (SOC) dynamics remain unknown. In this study, we investigated how the SOC content was determined by flooding duration and soil physicochemical variables in adjacent

Research on regional development has recently explored new domains, including agency. Evolutionary perspectives link new development paths to technological innovations and adaptation of economic structures to changing environments. In contrast, the agentic perspective attributes the formation of new development paths to the purposeful actions of human actors. A broad interpretation of the notion o

Traumatic brain injury (TBI) is a major cause of morbidity and mortality, not least in the elderly. The incidence of aged TBI patients has increased dramatically during the last decades. High age is a highly negative prognostic factor in TBI, and pharmacological treatment options are lacking. We used the controlled cortical impact (CCI) TBI model in 23-month-old male and female mice and analyzed t

We report the first large-scale retrospective cohort study on adolescent and young adult (AYA) polycythemia vera (PV) and essential thrombocythemia (ET) in Japan, a subgroup analysis using Japanese multicenter registry data (JSH-MPN-R18). This study included patients with PV (n = 31) or ET (n = 141) aged 20 to 39 years at the initial visit. Hemorrhage-free survival (HFS) was better in AYA ET than

How can feminist scholarship advance the field of foreign policy analysis to better understand contemporary foreign policy actions and challenges?This groundbreaking book provides the state-of-the-art in the study of gender, feminisms and foreign policy. Bringing together contributors from around the world, chapters offer new analyses of foreign policy topics, including diplomacy, trade, defence,

Introduction: The evidence-base for the impact of participating in the arts for different aspects of health and wellbeing is growing. Arts on Prescription has gained increasing recognition as a method for fostering connections among individuals and communities, however, to date no systematic review of the impact on individual health and wellbeing has been conducted. This review aims to provide an

Critical scholarship has long pointed to the problematic ways in which mainstream International Relations (IR) takes Westphalian state politics to be universally applicable, yet existing analyses fall short of providing an alternative grounding for IR. Departing from the close relationship between medicine and politics, this article advances two arguments. First, Westphalian IR is based on a parti

The enteric nervous system (ENS) orchestrates intricate and autonomous functions throughout the gastrointestinal (GI) tract. Disruptions in ENS function are associated GI disorders. This mini review focuses on the past decade's research, utilizing rodent models, with an emphasis on protecting enteric neurons from loss. The review specifically looks at efforts to reduce oxidative stress, limit infl