Neuroinflammation is associated with l-DOPA treatment in Parkinson's disease (PD), suggesting a role in l-DOPA-induced dyskinesia (LID), however it is unclear whether increased inflammation is specifically related to the dyskinetic outcome of l-DOPA treatment. Diversely from oral l-DOPA, continuous intrajejunal l-DOPA infusion is associated with very low dyskinetic outcome in PD patients. We repro

Rotigotine acts in vitro as a full agonist of dopamine D1 receptors at concentrations almost superimposable to those at which it acts on D2 receptors. However in vivo evidence of the differences between the agonist activity of rotigotine at D1 receptors from that on the D2 receptors has not been provided yet. In order to test the ability of rotigotine to stimulate dopamine D1 and D2 receptors in v

Withania somnifera Dunal (Indian Ginseng) has recently been shown to impair ethanol self-administration. In order to gain further insights on the ability of the Withania somnifera standardised root extract (WSE) to affect the motivational properties of ethanol, this study investigated whether WSE may also affect ethanol (2 g/kg)-elicited conditioned place preference (CPP) and aversion (CPA). To th

Adolescent Cannabis exposure has been hypothesized to act as a gateway to opiate abuse. In order to investigate the role of genetic background in cannabinoid-opiate interactions, we studied the effect of Δ(9) -tetrahydrocannabinol (THC) exposure of adolescent Lewis and Fischer 344 rats on the responsiveness of accumbens shell and core dopamine (DA), as monitored by microdialysis, to THC and heroin

Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its

Wide-VDD-range processors offer high energy efficiency for varying embedded workloads. But reducing the VDD of the cache as aggressively as the VDD of the CPU logic is not straightforward, since standard 6T SRAMs cease to operate at lower VDDs. We implement a data and instruction filter cache, using logic cells located in the CPU VDD domain, to permit the level-1 (L1) cache to be reliably powered

Several new architectures are under investigation for cloud radio access networks, assuming distinct splits of functionality among the network elements. Consequently, the research on radio data compression for the fronthaul is based on assumptions that correspond to a wide variety of tradeoffs among data rate, signal distortion, latency, and computational cost. This letter describes a method for L

With the RB3-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of C18 at a projectile energy around 425A MeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of C17 into the ground state of C18. Those data have been used to constrain theoretical calculations for transitions populating excited states in C18.

Co-design of monolithically-integrated millimetre-wave front-ends and antennas is alleviated by accurate device models. In this paper, a novel transmission line model for slotcoupled dielectric resonator antennas is proposed and verified. It describes distributed interaction between the coupling-structure and the radiating dielectric body of the antenna. This model thereby provides a simplistic an