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Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People

Objective: To identify biomarker patterns typical for Alzheimer disease (AD) in an independent, unsupervised way, without using information on the clinical diagnosis. Design: Mixture modeling approach. Setting: Alzheimer's Disease Neuroimaging Initiative database. Patients or Other Participants: Cognitively normal persons, patients with AD, and individuals with mild cognitive impairment. Main Outc

The Autism-Tics, AD/HD and other Comorbidities (A-TAC) telephone interview: Convergence with the Child Behavior Checklist (CBCL).

Objective: To compare telephone interview screening for child psychiatric/neuropsychiatric disorders using the inventory of Autism-Tics, Attention deficit/hyperactivity disorder (AD/HD) and other Comorbidities (A-TAC) with results from the Child Behavior Checklist (CBCL). Background: The A-TAC is a parent telephone interview focusing on autism spectrum disorders (ASDs) and co-existing problems, de

Ionic switch controls the DNA state in phage λ.

We have recently found that DNA packaged in phage λ undergoes a disordering transition triggered by temperature, which results in increased genome mobility. This solid-to-fluid like DNA transition markedly increases the number of infectious λ particles facilitating infection. However, the structural transition strongly depends on temperature and ionic conditions in the surrounding medium. Using ti

Evaluation of selective broadcast algorithms for safety applications in vehicular ad hoc networks

Just as the wireless communication technology develops further to achieve higher performance, new application areas emerge to challenge its limits. Vehicular ad hoc networks are one of these areas; and emergency situation warning is one of their most popular potential applications since traffic safety is a real concern for everyone. Due to the life-critical nature of emergency applications, howeve

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up to

Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy

Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients w

Emerging regional climate change signals for Europe under varying large-scale circulation conditions

A large ensemble of regional climate model projections was investigated regarding if and when they show an emergence of significant climate change signals in seasonal temperature and precipitation within Europe. The influence of the North Atlantic Oscillation (NAO), as simulated in the projections, was investigated. In most parts of Europe, the projections indicate robust emergence of temperature

MDM2 SNP309 promoter polymorphism, an independent prognostic factor in chronic lymphocytic leukemia

Background: The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors. Objective: In this study, the role of the polymorphism was investigated with regard to the clinical outcome in B-cell chronic lymphocytic leukemia

Cryostructuration as a tool for preparing highly porous polymer materials

Cryostructuration is a technique which can be used to produce highly porous polymer materials from either monomeric or polymeric starting material. The technique utilizes freezing of dilute solutions or suspensions for the formation of porous materials. The process has been used in both aqueous and organic media for the preparation of porous materials. This mini-review highlights some recent trend

The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy.

Implant-assisted targeting of magnetic particles under the influence of an external magnetic field has previously been verified through mathematical modeling, in vitro studies, and in vivo studies on rat carotid arteries as a feasible method for localized drug delivery. The present study focuses on the development of nanoparticles for the treatment of in-stent thrombosis. Magnetic nanoparticles in

Impact of plasma dynamics on equivalence ratio measurements by laser-induced breakdown spectroscopy

The systematic errors introduced by triggering a USB spectrometer for laser-induced breakdown spectroscopy equivalence ratio measurements are studied. We analyze the temporal behavior of laser-induced plasma in a nonreacting methane/air mixture and investigate the influence of the dynamics on equivalence ratio measurements with gated and ungated detection. For use of gated detectors, optimal delay

Tailored Formation of N-Doped Nanoarchitectures by Diffusion-Controlled on-Surface (Cyclo)-Dehydrogenation of Heteroaromatics

Surface-assisted cyclodehydrogenation and dehydrogenative polymerization of polycyclic (hetero)aromatic hydrocarbons (PAH) are among the most important strategies for bottom-up assembly of new nanostructures from their molecular building blocks. Although diverse compounds have been formed in recent years using this methodology, a limited knowledge on the molecular machinery operating at the nanosc

The politics and policy of carbon capture and storage: Framing an emergent technology

Over the past decade carbon capture and storage (CCS) has attracted increasing international attention as a climate change mitigation option and moved into the center of climate policy debates and negotiations. This special issue of Global Environmental Change brings together leading scholars to analyze the politics, policy and regulation of CCS in cross-country comparisons as well as in a global

Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members

AimsExercise increases risk of ventricular arrhythmia in subjects with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the impact of exercise on myocardial function in ARVC subjects. Methods and ResultsWe included 110 subjects (age 4217years), 65 ARVC patients and 45 mutation-positive family members. Athletes were defined as subjects with 4h vigorous exercise/week [