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IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes

In autoimmune/lymphoproliferative syndrome (ALPS), defective Fas death receptor function causes lymphadenomegaly/splenomegaly, the expansion of T-cell receptor αβ+ CD4/CD8 double-negative T cells, and frequent development of hematologic autoimmunity. Dianzani autoimmune lymphoproliferative disease (DALD) has a similar phenotype but lacks the expansion of double-negative T cells. This work shows th

ICOS-ligand triggering impairs osteoclast differentiation and function in vitro and in vivo

Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T

Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo

Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteopontin functions are modulated by thrombin cleavage generating N- and C-terminal fragment, whose individual roles are only partly known. Published data are diffic

Ecological interactions in human modified landscapes : Landscape dependent remedies for the maintenance of biodiversity and ecosystem services

Mycket har skett i jordbruket det senaste århundradet. Vi har rört oss från ett småbondesamhälle till ett mekaniserat, industrialiserat och kapitaliserat jordbrukssamhälle med en global marknad. Denna intensifiering av jordbruket har lett till förlust och fragmentering av biotoper vilket givetvis har påverkat den biologiska mångfalden negativt. När arter minskar eller försvinner riskerar vi även aModern agricultural practices have led to an intensification of the agricultural landscape which has negatively affected both biodiversity and the ecosystem services it provides. In my thesis I have used ecological theory of optimal foraging to try and explain how landscape structure, landscape composition and agricultural management can explain the loss of biodiversity and how remedies can effici

A functional MRI-Based Model for Individual Memory Assessment in Patients Eligible for Anterior Temporal Lobe Resection

Aim:To investigate if pre-operative fMRI memory paradigms, add predictive information with regard to post-surgical memory deficits.Methods:Fourteen pharmacoresistant Temporal Lobe Epilepsy (TLE) patients accepted for Anterior Temporal Lobe Resection (ATLR) were included. A clinical risk assessment score (RAS 0-3) was constructed from structural MRI, neuropsychological testing and hemisphere domina

Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem Cells

The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. During my PhD, I