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PROTEIN FOLD SWITCHING IN COARSE-GRAINED MODELS

Popular Abstract in Swedish Proteiner är livsnödvändiga. I grunden består de av utsträckta kedjor av aminosyror, av vilka det endast finns 20 olika sorter. Dessa är dock nödvändiga för livsviktiga funktioner i organismer, så som att agera som katalysatorer för biokemiska reaktioner, att transportera molekyler och att strukturellt hålla ihop vävnad. Proteiner är ofta specialiserade för deras givna Proteins carry out the instructions encoded in genes and are crucial for many important tasks in the living organism. Often the specific three dimensional structure, or fold, of a protein enables it to carry out a given task. It is an open question whether protein folds have arisen independently or whether mutations to existing protein sequences have caused switches to new folds. In the main part

Kultur och ekologi i Amazonas: GIS-bearbetning av historiska data om indianfolkens utbredning

This study deals with some contested issues regarding prehistoric cultural development in Amazonia and the colonial impact on the native inhabitants of the area. It focuses on the relation between groups belonging the language families of Tupí and Gê, on one hand, and the different ecological zones that they inhabit, on the other. GIS mapping is used to visualise the distribution and movements of

Evidence for adaptive variation at the genes coding for cytosolic phosphoglucose isomerase (PGIC) in Festuca ovina L.

Popular Abstract in English Darwin’s masterpiece “On the origin of species” describes how populations (one group of individuals from the same species that can easily mate with each other and that occupy the same geographic area) evolve through the process of natural selection, which can be shortly abbreviated as the survival of the fittest. More specifically, the individuals within one population The gene (Pgi) encoding the enzyme phosphoglucose isomerase (PGI) which plays a central role in the main pathways of carbon metabolism has been shown to be of adaptive significance in a wide range of different species. Earlier studies of enzyme electromorph variation in the grass Festuca ovina suggest that variation in cytosolic PGI (PGIC) may be involved in the adaptive response of F. ovina to th

Thread-level speculation as an optimization technique in Web Applications — Initial results

Web Applications have become increasingly popular as they allow developers to use an uniform platform for user interactions. The dynamic programming language JavaScript used in most Web Applications has performance penalties, that have been addressed by traditional optimization techniques. We have found that while the performance gain of such techniques are positive for a set of established benchm