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Accuracy – Adapting to creative and collaborative use in rural areas for circularity

Background and aim. In rural areas, economic and demographic shifts often leave buildings vacant due to functional and locational obsolescence. However, these buildings hold significant value in terms of embodied energy, natural resources, economic capital, and cultural heritage. The real estate sector urgently needs innovative space use strategies and business models to tackle rising vacancy rate

Statistical documentation for multi-disease, multi-domain platform trials : our experience with the Staphylococcus aureus Network Adaptive Platform trial

Platform trials have become widely adopted across multiple disease areas over recent years, however, guidelines for operationalising these trials have not kept pace. We outline a series of documents that summarise the statistical components, and implicit processes, of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial to provide an informal template for other researchers and reviewer

Increased risk of postoperative complications after delayed stoma reversal : a multicenter retrospective cohort study on patients undergoing anterior resection for rectal cancer

Purpose: Defunctioning stoma (DS) has been suggested to mitigate the consequences of anastomotic leak (AL) after low anterior resection. Stoma reversal (SR) is commonly delayed for nonmedical reasons in many healthcare systems. This study investigated the impact of the elapsed time from AR to SR on postoperative 90-day complications. The secondary aim was to explore the independent factors associa

Rapid ER remodeling induced by a peptide-lipid complex in dying tumor cells

The membranous ER spans the entire cell, creating a network for the biosynthesis of proteins and lipids, cell-wide communication, and nuclear delivery of molecules, including therapeutic agents. Here, we identify a novel ER response triggered by the tumoricidal complex alpha1-oleate, defined by a loss of peripheral ER structure, extensive ER vesiculation. Alpha1-oleate was present in the ER-derive

Vacant space in smaller swedish municipalities : Inventory and new space use concepts

Background and aim.The pandemic accelerated green and digital transition may benefit smaller towns. New opportunities include multi-locational living and working, emerging industries, and novel services to attract creative industries. All these developments entail more freedom for people to choose their place of living. Meanwhile, the real estate sector is in dire need of novel space use concepts

Foreign ownership and board cultural diversity

Using detailed hand-collected data on firm ownership and board cultural diversity from Sweden, we find that foreign ownership is positively associated with board cultural diversity. This relationship is not an artifact of foreign owners joining the board, and it is not driven by firms with substantial foreign focus. The presence of foreign owners on nomination committees seems to be the channel th

Antisecretory factor in severe traumatic brain injury (AFISTBI) : protocol for an exploratory randomized placebo-controlled trial

Background: Despite recent advances in neuroimaging and neurocritical care, severe traumatic brain injury (TBI) is still a major cause of severe disability and mortality, with increasing incidence worldwide. Antisecretory factor (AF), commercially available as Salovum®, has been shown to lower intracranial pressure (ICP) in experimental models of, e.g., TBI and herpes encephalitis. The aim of this

Perceived barriers and facilitators to exercise adherence in osteoarthritis : A thematic synthesis of qualitative studies

Objective: Exercise is a first-line intervention for osteoarthritis (OA). However, exercise adherence remains low, and existing studies exploring factors influencing adherence have yielded inconclusive results based on quantitative data. This study aims to synthesise qualitative studies focused on the perceived facilitators and barriers affecting exercise adherence in individuals with OA. Design:

Simultaneous shape and topology optimization on unstructured grids

In this work we present a simultaneous shape and topology optimization framework that generates large-scale 3D designs on unstructured grids. We consider a “parameter-free” shape optimization approach, wherein the nodal coordinates in the finite element mesh serve as design variables. To regularize the design changes we use a PDE-based filter, similar to the filtering techniques used in topology o

The ESCAPER Study - exploring protective mechanisms against cardiovascular disease in subjects at high risk : Rationale, study protocol, and first results

IntroductionThe ESCAPER project explores cardiovascular resilience in individuals who, despite a high-risk factor burden-longstanding Type 1 Diabetes (T1D), obesity, or kidney failure-avoid or delay macrovascular complications. This suggests underlying protective mechanisms. Initiated in September 2022, this exploratory study aims to uncover and define these mechanisms, potentially leading to nove

Prenatal exposure to organochlorine pesticides and polychlorinated biphenyls and risk of testicular germ cell cancer later in life

Introduction: Exposure to environmental chemicals during fetal development may increase the risk of testicular germ cell cancer (TGCC), but few studies have tested the hypothesis. We focused on organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), previously investigated in relation to other male reproductive health outcomes. Methods: We conducted a nested case-control study of 33

Modelling of anisotropic high-cycle fatigue of metals

A continuum approach for anisotropic high-cycle fatigue modelling for metals is described. The approach is based on the idea of an endurance surface moving in the stress space where the movement is described by a back-stress tensor. The movement of the endurance surface is governed by an evolution equation. Thereby, the back stress tensor memorizes the load history so that fatigue damage accumulat

Controls on the termination of the massive chert system in the Ediacaran-Cambrian Liuchapo Formation, South China

The widespread deposition of marine siliceous rocks marks a fundamental shift in the ancient ocean's biogeochemical dynamics, transitioning from Precambrian systems dominated by direct inorganic silica precipitation as the primary silicon sink to modern environments where microbial processes strongly govern silica dissolution. The massive Liuchapo chert in the Nanhua Basin, South China, formed dur

Governance, Good

This article argues that despite the fact that “good governance” has acquired a very particular set of meanings within the international development community, this remains an inherently contested and political concept. It traces the emergence of a good governance agenda within international development—and particularly within the World Bank—and identifies the important shifts that have occurred i

Integrated conodont biostratigraphy and stable isotope chemostratigraphy from the Tremadocian (Lower Ordovician) of the Yangtze Platform, South China

Tremadocian (Lower Ordovician) carbonate rocks were collected from the Xiangshuidong section in the Hubei Province, South China, and analysed for conodont biostratigraphy. A total of 24 species belonging to 16 genera were recovered from the Nantsinkuan and Fenhsiang formations. Three conodont zones are recognized based on this material: the Rossodus manitouensis Zone, Colaptoconus quadraplicatus–P

Direct observations of nucleation and early-stage growth of Au-catalyzed GaAs nanowires on Si(111)

Developing a reliable procedure for the growth of III-V nanowires (NW) on silicon (Si) substrates remains a significant challenge, as current methods rely on trial-and-error approaches with varying interpretations of critical process steps such as sample preparation, Au-Si alloy formation in the growth reactor, and NW alignment. Addressing these challenges is essential for enabling high-performanc

Improving Sample Preparation for Cancer Diagnostics

Varje år dör nästan 10 miljoner människor i cancer, många av dem hade kunnat räddas genom tidigare diagnostisering. Capillon Analytics är ett företag som startade som ett forskningsprojekt vid Lunds universitet. De utvecklar en metod för att identifiera tidiga tecken på cancer genom håranalysering och siktar mot klinisk validering 2026. I samarbete med dem var målet med detta examensarbete att stöEvery year, around 10 million people die from cancer, many of whom could have been saved through earlier detection. Capillon Analytics is a company that grew out of research at Lund University and is developing a method for identifying early signs of cancer using hair analysis and are aiming for clinical validation in 2026. In collaboration with them, the aim of this thesis was to support their wo

Marine Biobased Materials: Comparative Study of Hygroscopic Behaviour and Environmental Impact in Interior Applications

Growing environmental concerns have brought a focus to the impact of building materials. In response, biobased alternatives are being explored for their potential to reduce embodied carbon, support circularity, as well as improve indoor environmental quality. This is particularly important in Scandinavia, where moisture-related issues are common, there is a growing need for locally available mater