The objective of this study was to examine the effects of heparan sulfate (HS) on factors involved in the remodeling of connective tissue observed in patients with fibrotic respiratory disorders such as asthma. A suitable working model is to stimulate human fetal lung fibroblasts in vitro with structurally different forms of HS. Highly sulfated and iduronic acid (IdoUA)-rich HS specifically decrea

Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor with metastatic potential. We performed cytogenetic analysis on 10 1 GCTB from 92 patients. Karyotypes were obtained from 95 tumors, 47 of which had clonal aberrations. The majority of the cytogenetically abnormal GCTB had multiple, up to 28 per tumor, clones. Clonal telomeric associations (tas) and other structural and numer

Radiologic evaluation of patients with dysphagia relies on a meticulous and standardized technique. For assessment of function video recording is mandatory. A systematic approach for the description of function and dysfunction is necessary. The following describes such an approach focused on an easy and reproducible technique and a comprehensive description of radiologic events and morphology.

Dystroglycan (DG) is a widely expressed extracellular matrix (ECM) receptor required for muscle viability, synaptogenesis, basement-membrane formation and epithelial development. As an integral component of the Dystrophin-associated glycoprotein complex, DG plays a central role in linking the ECM and the cytoskeleton. Disruption of this linkage in skeletal muscle is the underlying cause in various

The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 da

Along the Sutlej valley, the lower package of the Higher Himalayan Crystallines (HHC) exposes a small concordant to discordant intrusive grey granite-The Maglad Khad Granite, within garnet mica schist/banded gneiss of the Jeori Formation. This body is fine grained and foliated along the margins, whereas the central part is relatively undeformed. This body along with aplites and pegmatites intrudes

Abstract A technique for assessing the metabolically-active fungal biomass by means of fluorescein diacetate (FDA) staining was recently described (Söderström, 1977). In this note some practical details in the application of this technique to studies of FDA-active fungal biomass in the soil are discussed.

Introduction and presentation to the six essays that encompasses the issue at hand.

Asporin, a novel member of the leucine-rich repeat family of proteins, was partially purified from human articular cartilage and meniscus. Cloning of human and mouse asporin cDNAs revealed that the protein is closely related to decorin and biglycan. It contains a putative propeptide, 4 amino-terminal cysteines, 10 leucine-rich repeats, and 2 C-terminal cysteines. In contrast to decorin and biglyca

A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and nonin

The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the activities of triacylglycerol lipases. In this study, we demonstrate that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG breakdown in in vitro assays and in organ cultures of murine white adipose tissue (WAT). To differentiate between ATGL- and

Analyses and a discussion of the consequences for lightweight structures, typical wood frame or truss structures, when a change of the statistical description of random parameters in a reliability based code format is made without considering how the code once was derived is presented. The special case when the statistical description of variable load is altered, is described with and without cons

Background: The usual onset of Crohn's disease (CD) is between 15 and 30 years of age, thus affecting people during their most economically productive period in life. Methods: This study intended to estimate societal costs and health-related quality of life (HRQoL) in Swedish patients in different stages of CD. Cross-sectional data on disease activity (measured with the Harvey-Bradshaw Index [HBI]

This article presents a method for measuring individual cutting forces during bandsawing. Methods for detecting errors in cutting edge positions, tool dynamics during machining and geometry changes due to wear have also been developed. The experimental studies that we have conducted show that the cutting forces vary during the tool engagement. These variations in force were then quantified using a

The long-term advance in the timing of bird spring migration in the Northern Hemisphere is associated with global climate change. The extent to which changes in bird phenology reflect responses to weather conditions in the wintering or breeding areas, or during migration, however, remains to be elucidated. We analyse the relationships between the timing of spring migration of 9 species of trans-Sa

OBJECTIVE: To study the impact of antihistamine use in early pregnancy on delivery outcome. METHODS: Using prospectively collected information on drug use in early pregnancy, delivery outcome was studied among 17 266 women with 17 776 deliveries and 18 197 infants. The analysis was performed according to the main reason for antihistamine use: nausea and vomiting in pregnancy and allergy. RESULTS: