Nanoscale detection of insulin granule sub-structures using dSTORM imaging
Diabetes mellitus is a global disease, mainly caused by insufficient insulin secre- tion from pancreatic islet β-cells. Insulin is stored in the granules of islet β-cells and released in response to extracellular stimuli e.g. glucose. The state of insulin structure and maturation determines the quality of the released insulin, However, the insulin state in the granules is rarely investigated due t