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Verapamil Inhibits L-type Calcium Channel Mediated Apoptosis in Human Colon Cancer Cells.

PURPOSE: Treatment with calcium channel blockers have been associated with increased colon cancer mortality in epidemiologic studies. We examined the potential expression and function of calcium channels in two human colon cancer cell lines. METHODS: Both primary (collected at operation) and commercially-available human colon cancer cell lines were used. The colon cancer cells were incubated with

Prostacyclin Infusion May Prevent Secondary Damage in Pericontusional Brain Tissue.

BACKGROUND: Prostacyclin is a potent vasodilator, inhibitor of leukocyte adhesion, and platelet aggregation, and has been suggested as therapy for cerebral ischemia. A case of focal traumatic brain lesion that was monitored using intracerebral microdialysis, and bedside analysis and display is reported here. When biochemical signs of cerebral ischemia progressed, i.v. infusion of prostacyclin was

Indications for hip and knee replacement in Sweden.

Objectives The aim of this paper was to compare selected indication parameters for patients scheduled for hip and knee replacement at orthopaedic units in Sweden. Methods Swedish orthopaedic clinics performing joint replacement were invited to enrol in the study. The study time was set to 2 years (from June 2006 to June 2008). The study subjects were patients undergoing hip or knee replacement for

An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group.

Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (MRI) scale for haemophilic arthropathy, two scales of a combined MRI scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty-one joint MRI's of 46 patients with haemophilia were evaluated by four radiologists using

Spatiotemporal separation of high harmonic radiation into two quantum path components

We present a spatiotemporal analysis of high harmonic generation, showing evidence for the presence of several quantum path contributions to the atomic dipole moment. We show that the harmonic radiation can largely be described as a sum of two fields having a phase proportional to the intensity of the generating field. We compare our results to recent experimental results demonstrating this separa

Polarization of high-order harmonics

We report measurements and calculations of the polarization state of high-order harmonics generated by a 790-nm Ti:sapphire laser. The problem of completely characterizing the polarization state of a partially polarized radiation in the XUV range is discussed in detail. The comparison between several gases, xenon, argon and neon, and different orders, from the 17th to the 33rd, shows that the rota

Ultrasound Doppler Vector Tomography - Measurements of Directional Blood Flow

An experimental system has been developed to verify the possibility of detecting flow activity using a technique called ultrasound Doppler vector tomography. A tomography algorithm is used to reconstruct blood flow vector fields using data from computer-controlled ultrasound continuous-wave Doppler scanning equipment. The result is a picture in which the brightness variations represent the reconst

Governing the transition to low-carbon energy and transport systems

For reprint orders, please contact reprints@ future-science. com stakeholders, markets and institutions. Experience shows that straightforward regulation can be justifiable and effective in some areas (eg, building codes and appliance standards), benefit sharing schemes are often important to ensure stakeholder buy-in (eg, local acceptance for wind power) and public–private partnerships can be imp

Cystatin C and cathepsins in cardiovascular disease.

Cystatin C and cathepsins could play a role in almost all processes involved in atherosclerotic lesion formation by their degradation of extracellular matrix proteins and apolipoprotein B100, the protein moiety of LDL. Several cysteine cathepsins are upregulated in human lesions accompanied by a decrease in cystatin C, the major inhibitor of cysteine cathepsins. Recent research show that atheroscl

Early surgical results after pneumonectomy for non-small cell lung cancer are not affected by preoperative radiotherapy and chemotherapy.

BACKGROUND: Higher operative risks after pneumonectomy for non-small cell lung cancer (NSCLC) have been reported after neoadjuvant chemotherapy or radiotherapy, or both. Patients who underwent pneumonectomy for NSCLC were evaluated for effect of neoadjuvant treatment on mortality and morbidity, especially bronchopleural fistula. METHODS: Between 1996 and 2003, 130 consecutive patients underwent pn

Could Quality of Life Impact the Prevalence of Metabolic Syndrome? Results from a Population-Based Study of Swedish Women: The Women's Health in the Lund Area Study.

Abstract Background: The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiovascular disease. Metabolic syndrome could be associated with impaired quality of life (QoL). Methods: The Women's Health in the Lund Area (WHILA) project covers 10,766 women born between December 2, 1935, and December 1, 1945, living in the Lund area, of Sweden by December 1, 1995.

Ectopic Ependymal Cells in Striatum Accompany Neurogenesis in a Rat Model of Stroke.

Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral arte

Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome?

OBJECTIVE: To compare neonatal outcome of blastocyst and cleavage stage embryo transfers after IVF. DESIGN: Register study. PATIENT(S): Treatments reported from all Swedish IVF clinics. INTERVENTION(S): None. SETTING: Births recorded in the Swedish Medical Birth Register after IVF performed, 2002-2006. MAIN OUTCOME MEASURE(S): Some neonatal characteristics were compared in 1,311 infants born after

Risk of coronary heart disease in patients with cancer: A nationwide follow-up study from Sweden.

BACKGROUND: Risk of coronary heart disease (CHD) in cancer patients has not been thoroughly investigated. The aim of the present study was to examine whether there is an association between cancer and first hospitalisation for CHD. METHODS: All individuals in Sweden with a diagnosis of cancer between 1st January 1987 and 31st December 2008 were followed for first hospitalisation for CHD. The refer

A label-free nano-liquid chromatography-mass spectrometry approach for quantitative serum peptidomics in Crohn's disease patients.

The identification of serum biomarkers for the diagnosis of inflammatory bowel diseases able to reduce the need for invasive tests represents a major goal in their therapy and follow-up. We report here a methodological approach for the evaluation of specific changes in the serum peptides abundance in healthy (H) and Crohn's disease (CD) subjects, based on a label-free LC ESI/Q-TOF differential mas