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Accelerating inference for diffusions observed with measurement error and large sample sizes using approximate Bayesian computation
In recent years, dynamical modelling has been provided with a range of breakthrough methods to perform exact Bayesian inference. However, it is often computationally unfeasible to apply exact statistical methodologies in the context of large data sets and complex models. This paper considers a nonlinear stochastic differential equation model observed with correlated measurement errors and an appli
Identification and characterization of new mechanisms in cardiovascular estrogen signaling
Women before menopause are protected from cardiovascular disease compared to age-matched men through mechanisms associated with the female sex hormone estrogen. There are three known estrogen receptors named ERα, ERβ and GPR30/GPER1, which are all three receptors are expressed in the cardiovascular system. Most known cardiovascular effects of estrogen are reported to be mediated via ERα but much l
Hydraulic performance of a full-scale peat and ash biofilter in treatment of industrial landfill leachate.
The purpose of this study was to evaluate the hydraulic performance of a full-scale on-site vertical-flow biofilter, consisting of a mixture of peat and carbon-containing ash, and a 500 m(3) equalization pond prior to the filter-system. The treatment plant was constructed to clean up leachate from an industrial mono-landfill that contained shredder residues of end-of-life vehicles and white goods.
Text-Brokering and Social Upheaval
High Familial Risk of Atrial Fibrillation/Atrial Flutter in Multiplex Families: A Nationwide Family Study in Sweden
Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on
Measurement of multi-scale deformation of polycarbonate using X-ray scattering with in-situ loading and digital image correlation
Deformation of amorphous, glassy polycarbonate (PC) is characterised over a wide range of length-scales using spatially-resolved wide angle X-ray scattering (WAXS) with simultaneous digital image correlation and in-situ uni-axial loading. Novel observations are presented on the correlation of the evolution of the molecular structure linked to the relevant local macroscopic measures of strain as th
Growing Up in Mommy’s Blog
This article introduces child-raising blogs in China. Written by mothers and their 6- to 12-year-old offspring, child-raising blogs contain diverse material from and about a child’s daily life and issues relating to a mother raising her offspring. Six blogs from mothers and their daughters are studied under the aspect of generational relations and the voice of children online with the aim of under
Ett med naturen
Mänskliga rättigheter i Kina – trender och diskussioner inför OS
DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.
Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.
Characterization of Microstructure and Mechanical Properties of High Chromium Cast Irons Using SEM and Nanoindentation
The effects of composition changes and heat treatment on the microstructure and mechanical properties of high-chromium white cast irons were studied in order to characterize possible improvements in product performance and machinability. Materials characterization was performed using nanoindentation, SEM, and EDS techniques. Present results show that changes in carbon and silicon contents as well
En historiker läser en diktsamling om ett våldsprojekt som kollapsat
Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals
Anti-neutrophil cytoplasmic antibodies (ANCAs) have a pathogenic role in ANCA-associated vasculitis. The origin of ANCAs and anti-glomerular basement membrane (GBM) antibodies, however, is unknown. In this study, we determined whether natural autoantibodies against myeloperoxidase (MPO), proteinase 3 (PR3), and GBM were present in each of 10 healthy Chinese and Swedish individuals, negative for al
Towards a tobacco-free generation. A study on the tobacco habits of adolescents: when, why and who?
Popular Abstract in Swedish Sammanfattning Varför ungdomar använder tobak är en stor och komplex fråga. Det finns faktorer på samhälls-, grupp- och individnivå som påverkar unga. Omgiv-ningens normer och attityder liksom föräldrars och kompisars tobaksvanor har betydelse och påverkar ungdomar att börja använda tobak eller att avstå. För att motverka tobaksbruk krävs en kombination av åtgärder på Why adolescents are using tobacco is a large and complex issue. There are factors on society, group and individual levels that affect the youngsters. The norms and attitudes in their surrounding, as well as the tobacco habits of parents and friends, are important when it comes to affecting adolescents to start using tobacco or abstain from it. Counteracting the use of tobacco requires a combinatio
Analytical modelling of hysteresis heating in rolling contact of rubber covered rollers
In a previous paper, an approximate model for the contact between a rubber covered roller and a rigid roller was developed as analytical functional relationships connecting geometric parameters and material properties of the rubber to nip properties such as maximum contact pressure, etc. in a two-dimensional relationship. The results from that development are used in this work, with the objective
Impaired Mitochondrial Function and Insulin Resistance of Skeletal Muscle in Mitochondrial Diabetes
OBJECTIVE - Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS - We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyoce
The reluctant rhetorician: senior managers as rhetoricians in a strategic change context
This paper explores strategic change communication, framed by the idea that managers can be viewed as rhetoricians. The purpose of this paper is to present and discuss senior managers’ subjective experiences of rhetorical aspects of change management. The paper draws on a case study from ABB Sweden (a power and automation technology company). In-depth interviews with senior managers, with vast ex
Business Ethics: A Double Bind
Introduction to special issue on Business Ethics, in the Journal of Business Anthropology. Today, business ethics can be found everywhere. But how can we define it intellectually? What does this concept include? How can we define it in explicitly anthropological terms? For the manager as well as the anthropologist, business ethics – in thoughts or in actions – involves dealing with opposing notion
Isolation and characterization of a stress responsive small GTP-binding protein AhRabG3b in peanut (Arachis hypogaea L.)
Rab7 is a member of small GTP-binding protein family involved in intracellular vesicle trafficking from late endosome to vacuole, some of them are found to be responsive by different environmental stresses. Here we report the isolation of a Rab7 (RabG3b) cDNA from peanut (Arachis hypogaea). Overexpression of the open reading frame (ORF) of Rab7 cDNA encoding 205 amino acids in E. coli conferred th