Type 2 diabetes (T2D) is characterized by insufficient insulin secretion and elevated glucose levels, often in combination with high levels of circulating fatty acids. Long-term exposure to high levels of glucose or fatty acids impair insulin secretion in pancreatic islets, which could partly be due to epigenetic alterations. We studied the effects of high concentrations of glucose and palmitate c

Background: Hepatopancreatoduodenectomy (HPD) is an aggressive operation for treatment of advanced bile duct and gallbladder cancer associated with high perioperative morbidity and mortality, and uncertain oncological benefit in terms of survival. Few reports on HPD from Western centers exist. The purpose of this study was to evaluate safety and efficacy for HPD in European centers. Method: Member

Background and Aims: Patients undergoing surgery are prone to infections, either at the site of surgery (superficial or organ-space) or at remote sites (e.g. pneumonia or urinary tract). Surgical site infections are associated with substantial morbidity and mortality, increased length of hospital stay and represent a huge burden to the health economy across all healthcare systems. Here we discuss

In the mid-2000s, Danish and Norwegian criminal procedural law underwent legislative amendments to strengthen the rights of complainants in cases of sexual violence and other cases of serious violations. While in Norway complainants were afforded participatory rights and stronger legal representation in court, this was largely not the case in Denmark. The aim of this chapter is to identify how the

Ribonucleotide reductases (RNRs) are essential for DNA synthesis in most organisms. In class-Ic RNR from Chlamydia trachomatis (Ct), a MnFe cofactor in subunit R2 forms the site required for enzyme activity, instead of an FeFe cofactor plus a redox-active tyrosine in class-Ia RNRs, for example in mouse (Mus musculus, Mm). For R2 proteins from Ct and Mm, either grown in the presence of, or reconsti

DescriptionHeat Transfer in Aerospace Applications is the first book to provide an overall description of various heat transfer issues of relevance for aerospace applications. The book contains chapters relating to convection cooling, heat pipes, ablation, heat transfer at high velocity, low pressure and microgravity, aircraft heat exchangers, fuel cells, and cryogenic cooling systems.Chapters spe

Using high-resolution synchrotron-radiation-based electron spectroscopy, vibrationally resolved C1s and S2p photoelectron spectra were obtained for the thiophene molecule in the gas phase. The vibrational structures were analyzed in terms of normal modes, and lifetimes were determined for the hole states. This complete analysis enabled to determine the binding energies of the chemically shifted ca

The three electromagnetic form factors for the transition from a 3/2+Σ∗ hyperon to the ground-state Λ hyperon are studied. At low energies, combinations of the transition form factors can be deduced from Dalitz decays of the Σ∗ hyperon to Λ plus an electron-positron pair. It is pointed out how more information can be obtained with the help of the self-analyzing weak decay of the Λ. In particular,

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Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. The