Immunoglobulin from insulin-dependent diabetic children inhibits glucose-induced insulin release
Immunoglobulin was separated from islet cel antibody positive plasma of six children with newly diagnosed insulin-dependent (type I) diabetes mellitus. The dynamics of insulin release in response to glucose and partially purified antibodies were determined in dispersed rat islet cells perifused on small columns of Biogel P-2 beads. After perifusion at 5.5 mmol/L D-glucose in the presence of health
