Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions is multifaceted and involves complex interactions between metabolic, inflammatory, and genetic factors. Here we assess the underlying structural and molecular processes focusing on the immunological phase of MASH in th

Agriculture has been dominated by annual plants, such as all cereals and oilseeds, since the very beginning of civilization over 10,000 years ago. Annual plants are planted and uprooted every year which results in severe disturbance of the soil and disrupts ecosystem services. Science has shown that it is possible to domesticate completely new perennial grain crops, i.e. planted once and harvestedNon-technical summary:Agriculture has been dominated by annual plants, such as all cereals and oilseeds, since the very beginning of civilization over 10,000 years ago. Annual plants are planted and uprooted every year which results in severe disturbance of the soil and disrupts ecosystem services. Science has shown that it is possible to domesticate completely new perennial grain crops, i.e. plan

Monitoring the spatial distribution and trends in surface greenhouse gas (GHG) fluxes, as well as flux attribution to natural and anthropogenic processes, is essential to track progress under the Paris Agreement and to inform its global stocktake. This study updates earlier syntheses (Petrescu et al., 2020, 2021, 2023), provides a consolidated synthesis of CH4 emissions using bottom-up (BU) and to

BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.MethodsWe randomly assigned ambulatory patients w

bjective: Evaluation of the hand function affected when replacing a malfunctioning hand by a bionic hand.Design: Case report.Subjects: One individual that wished for a better quality of life after unsatisfying hand function following a replantation.Methods: A quantitative and qualitative evaluation of body functions as well as activity performance and participation before and after a planned amput

The aim of the study is to gain knowledge about the transition to living with formal home care for cohabiting partners. Data consist of 14 interviews with partners aged 64–85, most with extensive experience of home care. Grounded in a life course perspective, the study identified the key factors in the process of becoming an ‘inadvertent care user’, and two modes for that transition: (1) adaptions

There are many explanations to the so-called rigour–relevancegap in academic research on strategic management. In this Element wereview existing literature on the matter and argue that we have to gobeyond the typical explanations of knowledge and language differencesand look at more fundamental, societal and cultural explanations.The empirical focus of this Element is the history and the possiblepThere are many explanations for the so-called rigor-relevance gap in academic research on strategic management. This Element reviews the existing literature on the matter and argues that it must go beyond the typical explanations of knowledge and language differences and look at more fundamental, societal, and cultural explanations. The empirical focus of this Element is the history and possible p

A search for Higgs boson pair production via vector-boson fusion is performed in the Lorentz-boosted regime, where a Higgs boson candidate is reconstructed as a single large-radius jet, using 140 fb−1 of proton–proton collision data at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Only Higgs boson decays into bottom quark pairs are considered. The search is particularly sen

The energy and mass measurements of jets are crucial tasks for the Large Hadron Collider experiments. This paper presents a new calibration method to simultaneously calibrate these quantities for large-radius jets measured with the ATLAS detector using a deep neural network (DNN). To address the specificities of the calibration problem, special loss functions and training procedures are employed,

This article unpacks the politics of disinformation attribution as deterrence. Research and policy on disinformation deterrence commonly draw on frameworks inspired by cyber deterrence to address the ‘attribution problem’, thereby overlooking the political aspects underpinning attribution strategies in liberal democracies. Addressing this gap and bringing together disinformation studies and the fo

This Letter presents results from a combination of searches for Higgs boson pair production using 126-140 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.4 assuming no Higgs boson pair production. Constraints o