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Neural organisation in the first optic ganglion of the nocturnal bee Megalopta genalis
Each neural unit (cartridge) in the first optic ganglion (lamina) of the nocturnal bee Megalopta genalis contains nine receptor cell axons (6 short and 3 long visual fibres), and four different types of first-order interneurons, also known as L-fibres (L1 to L4) or lamina monopolar cells. The short visual fibres terminate within the lamina as three different types (svf 1, 2, 3). The three long vis
Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer.
Controlled radial distribution of nanoscale vesicles during binding to an oscillating QCM surface
Direct capture of plasmid DNA from non-clarified bacterial lysate using polycation-grafted monoliths
Monolith columns from macroporous polyacrylamide gel were grafted with polycations, poly(N,N-dimethylaminoethyl methacrylate) (polyDMAEMA), (2-(methacryloyloxy)ethyl)-trimethyl ammonium chloride (polyMETA) and partially quaternized polyDMAEMA prepared via treating polyDMAEMA-grafted columns with propylbromide. The polymer grafting degrees varied between 34 and 110%. The polycation-grafted monolith
Dystrophia Helsinglandica: a new type of hereditary corneal recurrent erosions with late subepithelial fibrosis
Purpose: To describe the phenotype of an autosomal-dominant corneal dystrophy with an early onset of recurrent corneal erosions and development of subepithelial fibrosis in the cornea, and also to exclude genetic linkage to known corneal dystrophies with autosomal-dominant inheritance and clinical resemblance. Methods: We describe the medical history and clinical findings in individuals from a sev
Concurrent cetuximab and radiotherapy after docetaxel-cisplatin induction chemotherapy in stage III NSCLC: a phase II study from the Swedish Lung Cancer Study Group
One-dimensional PtO2 at Pt steps: Formation and reaction with CO
Using core-level spectroscopy and density functional theory we show that a one-dimensional (1D) PtO2 oxide structure forms at the steps of the Pt(332) surface after O-2 exposure. The 1D oxide is found to be stable in an oxygen pressure range, where bulk oxides are only metastable, and is therefore argued to be a precursor to the Pt oxidation. As an example of the consequences of such a precursor e
The Quantitative Relationship between Longitudinal and Radial Function in Left, Right and Total Heart Pumping in Humans.
The total heart volume variation (THVV) during systole has been proposed to be caused by radial function of the ventricles, but definitive data for both ventricles have not been presented. Furthermore, the right ventricle (RV) has been suggested to have a greater longitudinal pumping component than the left ventricle (LV). Therefore, we aimed to compare the stroke volume (SV) generated by radial f
Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells
Enforced expression of Hoxb4 dramatically increases the regeneration of murine hematopoietic stem cells (HSCs) after transplantation and enhances the repopulation ability of human severe combined immunodeficiency (SCID) repopulating cells. Therefore, we asked what physiologic role Hoxb4 has in hematopoiesis. A novel mouse model lacking the entire Hoxb4 gene exhibits significantly reduced cellulari
Apolipoprotein E genotyping in Alzheimer’s disease and frontotemporal dementia
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by progressive neuronal loss and microvacuolization, although with different distributions of cortical involvement. In contrast to AD there is no amyloid, senile plaques or tangles in FTD. The involvement of chromosome 19 in AD has been associated with apoliprotein E (ApoE) and the epsi4 gene frequency has been related to
Density functional theory for flexible and semiflexible polymers of infinite length
We develop a density functional theory for infinitely long flexible and semiflexible polymers, as an appropriate simplification of the corresponding treatment of finite chains. We demonstrate that very long chains sometimes are required to reproduce even qualitatively correct limiting behaviors.
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We p
How to develop strategies for improving musculoskeletal health.
Musculoskelecal conditions are a major cause of morbidity and evidence-based strategies - such as the European Action Towards Better Musculoskeletal Health - have been developed to reduce their incidence and impact on individuals and on society. This issue is based around that report. These strategies are inclusive of all major musculoskeletal conditions with recommendations for prevention and man
Radiative lifetimes of Zn I, II excited states
Radiative lifetimes of excited states of Zn I (3d(10)4sns S-3(1), n = 6-8; 3d(10) 4snd D-3, n = 4-7) and Zn II (3d(10) 4p P-2(1/2.3/2), 4d D-2(3/2,5/2), 3d(10)5S S-2(1/2)) have been measured using a time-resolved laser-induced fluorescence technique. Single- or two-step excitation of atoms and ions produced by laser ablation was employed. The experimental radiative lifetimes have been compared wit
Long-Term Follow-up of HCV Infected Stem Cell Transplant Patients and Effects of Antiviral Therapy.
The impact of foreign board membership on firm value
This study examines the effect of foreign (Anglo-American) board membership on corporate performance measured in terms of firm value (Tobin's Q). Using a sample of firms with headquarters in Norway or Sweden the study indicates a significantly higher value for firms that have outsider Anglo-American board member(s), after a variety of firm-specific and corporate governance related factors have bee
Prevalence of hemochromatosis gene (HFE) mutations in Greece
The frequencies of the hereditary hemochromatosis gene (HFE) mutations C282Y and H63D vary between different populations. There are a limited number of reports regarding the frequency of these mutations in populations of southeastern Europe. Two hundred and sixty-four adult individuals of Greek origin were examined for the C282Y and H63D mutations to determine the allele and genotype frequencies.
Long-term assessment of striatal dopamine transporters in parkinsonian patients with intrastriatal embryonic mesencephalic grafts
Purpose: Single-photon emission computed tomography (SPECT) of striatal dopamine transporters (DAT) has been used to demonstrate presynaptic dopaminergic dysfunction and to monitor the progression of Parkinson's disease. In parkinsonian patients who were implanted with embryonic mesencephalic tissue in the striatum, positron emission tomography (PET) has shown an increase in striatal [F-18]dopa up
Nitric oxide gives maximal response after coronary artery bypass surgery
The dose-response to inhalation of nitric oxide (NO) after coronary artery bypass surgery was studied in seven patients with normal preoperative lung function and chest radiograms. During postoperative controlled ventilation with PEEP 5 and 10 cmH2O, the patients inhaled NO in concentrations of 2 to 25 ppm, in random order, for 6 to 10 minutes. Hemodynamic and oximetric data were analyzed before,
