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Data on familial risks in penile and vulvar/vaginal cancers and in second primary cancers (SPCs) following these cancers are limited. We used the Swedish Family-Cancer Database from years 1958 through 2015 to identify 3641 penile and 8856 vulvar/vaginal cancers and to calculate relative risks (RRs) and 95% confidence intervals (CIs) for these cancers according to site-specific cancer in family mem

Outside of the photosynthetic machinery, high-valent manganese cofactors are rare in biology. It was proposed that a recently discovered subclass of ribonucleotide reductase (RNR), class Id, is dependent on a Mn2(IV,III) cofactor for catalysis. Class I RNRs consist of a substrate-binding component (NrdA) and a metal-containing radical-generating component (NrdB). Herein we utilize a combination of

Oxidation-reduction potential (ORP) is an environmental factor of importance in several biological conversion processes. Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative disruption of the cellulose chain in the presence of oxygen or hydrogen peroxide and increase enzymatic hydrolysis yields. However, the enzymes are also sensitive to oxidative damage and the level of oxidative agent

Scope: Emerging evidence suggests that high-fat diet (HFD) is associated with gut microbiome dysbiosis and related disorders. Bilberry is a prebiotic food component with known health benefits. Herein, the dynamics of the colonic mucus layer and microbiome during HFD and bilberry supplementation are addressed. Methods and results: The effects on colonic mucus thickness in vivo and gut microbiota co

In the last decades spatiotemporal manifestations of shopping are changed radically in conjunction with proliferation of car usage, internationalization of retail, and establishment of out-of-town malls. The social, cultural, and economic backgrounds of this axis alteration and its implication to the city life have been discussed thoroughly. However, the main empirical focus laid mostly on the mai

Standing genetic variation represents a genetic load on population fitness but can also support a rapid response to short-term environmental change, and the greatest potential source of such standing genetic variation typically exists among locally adapted populations living along an environmental gradient. Here, we develop a spatially explicit simulation model to quantify the contribution of exis

Ge nanoparticles embedded in thin films have attracted a lot of attention due to their promising optical and electronic properties that can be tuned by varying the particle size and choice of matrix material. In this study, Ge nanoparticle formation was investigated for Al-Ge-N based thin films by simultaneous measurements of HAXPES and grazing incidence XRD during in situ annealing in vacuum cond

Motivated by experimental findings on sheet-metal forming, this article concerns the modeling of evolving anisotropies in finite plasticity. A covariant formulation of plasticity is employed in conjunction with evolution equations for the structural tensors that characterize the symmetry group of the yield function. A specific model is implemented into a finite element code to simulate tension and

The valence bands of [EMIM][TFSI], [DEME][TFSI] and [PYR1,4][TFSI] gas-phase ion pairs have been investigated using ultraviolet photoelectron spectroscopy (UPS). The photoelectron spectra are interpreted by using several density functional and ab initio calculation methods. Although the experimental vapor phase spectra are similar, the different calculation methods make different predictions about

Metamorphic provinces such as the ∼1 ​Ga Grenvillian, ∼400 ​Ma Caledonide and Triassic Qinling Provinces often contain rocks with high-pressure assemblages such as eclogites, which formed at mantle depths in subduction zones. These are evidence of the accretion of terranes by subduction of oceans and collision to form large tectonostratigraphic provinces. The Mesoproterozoic Namaqua-Natal Province

The world faces major climate challenges and extensive efforts need to be taken to combat this issue. Replacing fossil-derived fuels and chemicals with renewables are one important step on the way. Hydrogen has a great potential as a renewable energy carrier for the transport sector and as a green chemical for the industry. Today, the production of hydrogen stems primarily from fossil resources. A

A neural-network-based adaptive control scheme is developed for bilateral teleoperation systems with single-master-multiple-slaves in the presence of dynamic uncertainties and communication constraint. Discrete-time data transmitting communication network with bandwidth limitation and time-varying communication delays is considered and the Round-Robin scheduling protocol is used to orchestrate the

Objective: Fontan surgery is performed in children with univentricular heart defects. Previous data regarding permanent pacemaker implantation frequency and indications in Fontan patients are limited and conflicting. We examined the prevalence of and risk factors for pacemaker treatment in a consecutive national cohort of patients after Fontan surgery in Sweden. Methods: We retrospectively reviewe

As transport properties of doped ceria electrolytes depend significantly on the nature of the dopant and the defectivity, the design of new materials and devices requires proper understanding of the defect structure. Among lanthanide dopants, Yb shows some peculiar characteristics that call for a possible different defect structure compared to Gd and Sm conventional dopants, which could be linked

En signal är en fysisk kvantitet som varierar med någon oberoende variabel, t.ex. tid eller rum, som förmedlar information. En signal vars statistiska egenskaper är konstant i tid kallas stationär, medan signaler vars egenskaper varierar med tiden kallas icke-stationära, vilket är de vanligaste i naturen. Denna avhandling fokuserar på statistiska metoder för icke-stationära signaler. De applikatioThis thesis focuses on statistical methods for non-stationary signals. The methods considered or developed address problems of stochastic modeling, inference, spectral analysis, time-frequency analysis, and deep learning for classification. In all the contributions, an example of a biomedical application of the proposed method is provided, either to electroencephalography (EEG) data or to Heart Ra

Artificial breeding of Rapana venosa has been attempted in China, but the high mortality rate of rapa whelk juveniles (10–40 mm) seriously restricts the breeding success of this species in artificial cultivation and the overall aquaculture industry, and thus the scale of industrialization is far from being realized. One main factor was found to contribute to this high mortality rate: the low preda

We propose a model for the axial growth rate of nanowires grown by means of the vapor-liquid-solid mechanism. Our model is based on deposition-desorption-incorporation kinetics in steady state, and using this model we discuss nanowire growth in two experimentally relevant limits: mass transport limited growth and incorporation limited growth. We discuss our modeling results in view of experimental

Exotic plants can compete well with native species because many invasive species are considered better nutrient users in both low- and high-resource environments. However, whether invasive plants can outperform native plants at all stages of invasion is not very clear. We investigated the nitrogen (N), phosphorus (P) and N:P homeostasis of an invasive Eupatorium adenophorum and a co-occurring nati

This study examines the geopolitical role of 14 metals and metalloids needed for renewable energy technologies. The analysis focuses on three factors with potential geopolitical importance: the geographic concentration of resources, potential revenues of resources rich countries and the size of total global markets. The geographic concentration of most of the fourteen studied metals and metalloids

Class Ib ribonucleotide reductases (RNR) utilize a di-nuclear manganese or iron cofactor for reduction of superoxide or molecular oxygen, respectively. This generates a stable tyrosyl radical (Y·) in the R2 subunit (NrdF), which is further used for ribonucleotide reduction in the R1 subunit of RNR. Here, we report high-resolution crystal structures of Bacillus anthracis NrdF in the metal-free form