If translation is an act of meaning transaction, semiotics should be able to define its specificity in relation to other semiotic acts. Instead, following upon suggestions by Roman Jakobson, the Tartu school, and, more implicitly, Charles Sanders Peirce, the notion of translation has been generalized to cover more or less everything that can be done within and between semiotic resources. In this p

The claim of cognitive semiotics to offer something new to semiotics rests on the ambition to bring together the research traditions of semiotics and cognitive science. Our focus has been on using the empirical approach of cognitive science in investigating semiotic issues. At the same time, however, phenomenological description plays a major part in preparing the studies and integrating their res

Standard signal processing techniques are implicitly based on the assumption that the signal lies on a regular, homogeneous domain. In practice, however, many signals lie on an irregular or inhomogeneous domain. An application area where data are naturally defined on an irregular or inhomogeneous domain is human brain neuroimaging. The goal in neuroimaging is to map the structure and function of t

The relatively new combustion concept known as partially premixed combustion (PPC) has high efficiency and low emissions. However, there are still challenges when it comes to fully understanding and implementing PPC. Thus a predictive combustion tool was used to gain further insight into the combustion process in late cycle mixing. The modeling tool is a stochastic reactor model (SRM) based on pro

Background: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. Results: Hippocampal slices from 6 days old mice showed

FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational entropy upon ligand binding. Here we report backbone and methyl-axis order parameters of the apo and FK506-bound forms of FKBP12, based on 15N and 2H NMR relaxa

The problem of low-rank approximation with convex constraints, which appears in data analysis, system identification, model order reduction, low-order controller design and low-complexity modelling is considered. Given a matrix, the objective is to find a low-rank approximation that meets rank and convex constraints, while minimizing the distance to the matrix in the squared Frobenius norm. In man

A transmission polarizer for producing elliptically polarized soft X-ray radiation from linearly polarized light is presented. The setup is intended for use at synchrotron and free-electron laser beamlines that do not directly offer circularly polarized light for, e.g., X-ray magnetic circular dichroism (XMCD) measurements or holographic imaging. Here, we investigate the degree of ellipticity upon

There is scientific evidence of accelerated sea level rise and saline intrusion. Some impacts, such as stratification and estuarine circulation, are subtle; others are dramatic including shifts in salt-sensitive habitats and limited water availability of suitable quality for industrial and municipal uses. These results have become a remarkable reality resulting in a set of integrated surface water

A new model; WORLD6 was developed. WORLD6 differs from the earlier system dynamics world models in several aspects. Several modules link the economy, materials, metals, energy, population and politics in a dynamic system. The present version is a result of a dismantling of the World3 model (Meadows et al., 1972, 1992, 2004) with an extension and substitution of its resource module and economy modu

The global supply of cobalt was simulated by combining 3 different system dynamics models; BRONZE, PGM and STEEL. The present use of cobalt shows a low degree of recycling and systemic losses are significant. The reserves of cobalt are not very large (20-25 million ton extractable) as compared to metals like copper, zinc or iron, and after 2170 cobalt will have run out under a business-as-usual sc

The complement system is an ancient part of the innate immune system important for both tissue homeostasis and host defense. However, bacteria like Staphylococcus aureus (SA) possess elaborative mechanisms for evading both the complement system and other parts of the immune system. One of these evasive mechanisms-important in causing chronic and therapy resistant infections-is the intracellular pe

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master- switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical- generating subunit. The ATP-co

Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previo