Sensitivity tests were conducted using a state-of-the-art aerosol–cloud to investigate the key microphysical and dynamical mechanisms by which solid aerosols affect glaciated clouds. The tests involved simulations of two contrasting cases of deep convection—a tropical maritime case and a midlatitude continental case, in which solid aerosol concentrations were increased from their pre-industrial (1

Dysfunctional insulin secretion is a hallmark of type 2 diabetes (T2D). Interestingly, several islet microRNAs (miRNAs) are upregulated in T2D, including miR-132. We aimed to investigate whether in vivo treatment with antagomir-132 lowers expression of miR-132 in islets thereby improving insulin secretion and lowering blood glucose. Mice injected with antagomir-132 for 24 h, had reduced expression

The study of burials can include, among other things, examinations of grave goods, architecture, osteological and organic remains, context and location, socio-religious and ritual importance, sacred landscape, socio-economic relevance, and so on. One area that has not been investigated in depth regarding the objects placed in the graves is the aspect of color: does their color in general or specifi

Background: Adjuvant chemotherapy (ACT) for breast cancer improves relapse-free survival (BCRFS) and overall survival. Differences in terms of efficacy and toxicity could partly be explained by the significant interpatient variability in pharmacokinetics which cannot be captured by dosing according to body surface area. Consequently, tailored dosing was prospectively evaluated in the PANTHER trial

Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 week

Avståndet till Luthers musikvärld är ansenligt. Kunskapen om reformatorns tolkning av musikens roll för människor, kyrka och samhälle har knappast utvecklats i aktuell forskning. Sådana kunskaper behövs dock, de är t.o.m. "högst centrala för [att förstå] Luthers tillvägagångssätt, och vågar jag påstå, också för hans framgång" påpekar Lundberg.

Nanowires are presently investigated in the context of various biological and medical applications. In general, these studies are population-based, which results in sub-populations being overlooked. Here, we present a single cell analysis of cell cycle and cell movement parameters of cells seeded on nanowires using digital holographic microscopy for time-lapse imaging. MCF10A normal-like human bre

Purpose: The purpose of this study is to investigate the effects of human capital and relational trust on business-to-business (B2B) brand equity. Design/methodology/approach: Data collection was conducted among the clients of one of the Big Four auditing firms in Sweden. Structural equation modeling was used to test the hypothesized effects. Findings: The results demonstrate positive effects of h

Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of different affinity forms of the integrin LFA-1. It has been suggested that LFA-1 may f

Protein-specific and shared genetic pathways influence the spread of amyloid-β and tau pathology. Hence, distinct gene expression profiles may induce regional vulnerability of the human cortex to the specific proteinopathies of Alzheimer’s disease.

Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine

A rigid mineral-based deposit, termed ultra-high temperature (UHT) fouling, is formed on heat exchanger surfaces during milk processing at 140 °C. The removal of this type of fouling is for the first time assessed using a laser triangulation sensor and a camera, to measure changes in the thickness and to visualize structural changes in the fouling in situ. The process was monitored during both the

Controllable particle assisted growth (PAG) of III-V nanowires is today almost exclusively done with Au, Ga or In nanoparticles, whereas other metals often yield nanowires with uncontrolled growth directions. To improve the control of the initial growth direction in PAG, independent of choice of metal, we propose to initiate nanowire growth from a group-III-rich foreign metal particle. For III-V n

Our understanding and quantification of global soil nitrous oxide (N2O) emissions and the underlying processes remain largely uncertain. Here, we assessed the effects of multiple anthropogenic and natural factors, including nitrogen fertilizer (N) application, atmospheric N deposition, manure N application, land cover change, climate change, and rising atmospheric CO2 concentration, on global soil

The use of a polar diagram method for describing and evaluating the machinability of Inconel 718 was explored. Five key parameters of the work material, representing the mechanical and physical properties which have strongest influence on its machinability, were employed in the diagrams. These five parameters were integrated into a single polar diagram, used to describe the machinability of Incone

Migrant integration is a long drawn out process requiring synergies with various dimensions of life, rhyming with those of the host country. In this paper, we attempt to deconstruct the digital narratives of migrant to explore how they may lead to a meaningful assessment of their acculturation and consequent integration in their host societies’. Drawing on acculturation theory as a lens, we argue

Background Prolonged angiogenesis inhibition may improve treatment outcome in metastatic colorectal cancer (mCRC) patients. However, due to the complexity of the angiogenic pathways there is a lack of valid predictive biomarkers for anti-angiogenic agents. Here, we describe and optimize a procedure for simultaneous dynamic profiling of multiple angiogenesis related proteins in patient serum to exp