A method for preparing ultrathin sections (- 20 nm) of inorganic solids has been developed using ultramicrotomy of resin-embedded crystal fragments. Undamaged crystals, oriented along a crystallographic direction, could be imaged with transmission electron microscopy (TEM) at a resolution better than 0.5 nm. The true internal structure of the crystals could be investigated by imaging the second in

OBJECTIVES: Diabetes mellitus is associated with a high cardiovascular morbidity which has been linked to disturbances in microvascular function. This study was designed to examine the transcapillary fluid absorption during experimental hypovolaemia in type 1 diabetes.SUBJECTS: Twelve males with type 1 diabetes (age 25 +/- 3 years, duration 8 +/- 1 years) with no clinical microangiopathy and 12 he

Among DQ6 molecules, DQA1(*)0102-DQB1(*)0602 is negatively associated with insulin-dependent diabetes mellitus (IDDM), but DQA1(*)0102-DQB1(*)0604 shows a neutral to positive association in Swedish children with IDDM. The aim of this study was to identify critical DQB1 residues that may account for the differences in IDDM association observed for these two DQ6 molecules. HLA-DQ genotyping in 425 I

Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid bilayers. Peripheral neuropathies, such as Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas syndrome (DSS), are incurable demyelinating conditions that result in pain, decrea

The typical approach for volumetric blood flow assessment consists of a velocity measurement performed in a single sample volume placed in the vessel centre, combined to an estimate of the average diameter. This simple approach produces large inaccuracies since it does not account for the complex flow configurations produced by complicated artery geometries and/or pulsatile conditions. Moreover, d

Background. Diabetes may be linked to incidence of different tumor diseases and prognosis through various mechanisms such as the disease itself, hyperglycemia, obesity and anti-diabetes therapy. Material and methods. The study includes all women with BC diagnosed in Sweden between 2000 through 2008 (n=54406). The women had no previous cancer diagnosis during the period of 1958-1999. Dates of birth

The Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) instrument onboard the Rosetta spacecraft has measured molecular oxygen (O 2 ) in the coma of comet 67P/Churyumov-Gerasimenko (67P/C-G) in surprisingly high abundances. These measurements mark the first unequivocal detection of O 2 in a cometary environment. The large relative abundance of O 2 in 67P/C-G despite its high react

The genetic etiology of Type 1 (insulin-dependent) diabetes mellitus is complicated by the apparent presence of several diabetes susceptibility genetic regions. Type I diabetes in the inbred BioBreeding (BB) rat closely resembles the human disorder and was previously shown to involve two genes: the lymphopenia (lyp) region on Chromosome (Chr) 4 and RT1(u) in the major histocompatibility complex (M

This paper presents and discusses a method using a range of techniques for assessing sensorial perception of product design and interaction. Collectively denoted ‘Five Senses Testing’, the purpose of the method is to facilitate the assessment of sensory experience related to product design and product use. Furthermore, the outcomes of using the techniques inform product design development by conne

Farmers feed the world. How do they think about and cope with a changing world?

Introduction: The purpose of the study was to elucidate the association between smoking and estradiol (E2) and testosterone (T) levels in young healthy women from highrisk families. Cigarette smoke contains multiple carcinogens and is considered a risk factor for breast cancer. However, tobacco also contains aromatase inhibiting substances, but the impact on hormonal levels in young women at the a

S2 has been observed for decades in comets, including comet 67P/Churyumov-Gerasimenko. Despite the fact that this molecule appears ubiquitous in these bodies, the nature of its source remains unknown. In this study, we assume that S2 is formed by irradiation (photolysis and/or radiolysis) of S-bearing molecules embedded in the icy grain precursors of comets and that the cosmic ray flux simultaneou