Development of inhibitors to coagulation factor VIII or IX is still the most challenging complication in haemophilia care. 'Bypassing agents' may be used to treat a bleed but the eradication of the inhibitor by immune tolerance induction (ITI) is the main objective in the treatment of a patient with haemophilia who has developed neutralizing antibodies. Several options exist for ITI and the patien

BACKGROUND/AIM: The value of androgen receptor (AR) in breast cancer has gained renewed interest as a prognostic and treatment predictive biomarker. The aims of this work were to study the associations and the prognostic value of AR in patients from two clinical cohorts.MATERIALS AND METHODS: Cohort 1 included 208 premenopausal, node-negative patients of whom 87% had received no adjuvant medical t

This special issue presents and discusses prominent methodsand tools for multimodal analysis and reception. It comprises an editorial, a set of six papers and a book review and brings together international researchers from Germany, Sweden, Denmark, United States and Singapore representing various disciplines: communication and media studies, social semiotics, cognitive science, educational psycho

Chondrules in primitive meteorites likely formed by recrystallisation of dust aggregates that were flash-heated to nearly complete melting. Chondrules may represent the building blocks of rocky planetesimals and protoplanets in the inner regions of protoplanetary discs, but the source of ubiquitous thermal processing of their dust aggregate precursors remains elusive. Here we demonstrate that esca

We briefly summarize the presentations and discussions from working group 5 (WG5), dedicated to high gradient plasma structures and advanced beam diagnostics, which occurred during the third edition of the European Advanced Accelerator Concepts Workshop (EAAC 2017).

Microalloying of stainless steel with reactive elements increases oxidation resistance but makes the alloy prone to microstructural changes. XPS results reveal changes in the initial oxidation mechanism on Ti-Nb stabilized ferritic stainless steel (EN 1.4521) after 120 h heat treatment at 650 °C. Age-precipitation of (FeCrSi)2(MoNb)-type Laves phase resulted in less pronounced surface segregation

The intestinal surface is daily challenged with tremendous amount of foreign material derived our diet and from the commensal bacteria that densely populate the mucosal surface. Occasionally the gut mucosa is exposed to pathogens trying to enter our body. The important task of the intestinal immune system is to remain tolerant toward innocuous luminal constituents and to elicit defense responses t

The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and HSC function is unclear. Here, we report that mice lacking Hlf are viable with essentially normal hematopoietic parameters, including an intact HSC pool durin

We develop an extended classical density-functional theory to describe clustering of imidazolium-based cations into linear chains, driven by π-π stacking. We find that the associating system displays a similar short-ranged structure to the completely dissociated fluid. We also construct a restricted primitive model for associating ionic species in an RTIL+solvent mixture. The double-layer formed i