Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m2 This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that G

In this paper, we present the case of a couple who refused to disclose the sex of their child to others, and some of the responses that this case prompted in the international media. We outline the ethical issues that this case raises, and we place it into the more general context of parental preferences regarding the gender (development) of their children and of the impact on children of parental

This paper presents a systematic account of ethical issues actualised in different areas, as well as at different levels and stages of health care, by introducing organisational and other procedures that embody a shift towards person centred care and shared decision-making (PCC/SDM). The analysis builds on general ethical theory and earlier work on aspects of PCC/SDM relevant from an ethics perspe

Although research indicates that single parenting is not by itself worse for children than their being brought up by both their parents, there are reasons why it is better for children to have more than one committed parent. If having two committed parents is better, everything else being equal, than having just one, I argue that it might be even better for children to have three committed parents

The prospect of ex vivo functional evaluation of donor hearts is considered. Particularly, the dynamics of a synthetic cardiac afterload model are compared to those of normal physiology. A method for identification of continuous-time transfer functions from sampled data is developed and verified against results from the literature. The method relies on exact gradients and Hessians obtained through

Objective: To describe and compare hip and groin strength and function of male ice hockey players over one season in players with and without hip and groin problems in the previous season. Design: Prospective cohort study. Setting: Swedish male ice hockey. Participants: We followed 193 players from 10 teams during the 2017/2018 season. Main outcome measures: Hip adduction and abduction strength, 5

Background: Research investigating neuromotor function in the absence of cerebral palsy (CP) for children who had neonatal HIE is limited. Aims: To investigate school-age neurological and neuromotor function, and correlations with attention, neonatal Magnetic Resonance Imaging (MRI), and neuromotor assessments at toddler age. Methods: Twenty-seven children with neonatal HIE without CP who underwen

When selecting for monoclonal antibodies of a desired affinity, affinity chromatography can be a feasible alternative. This is of particular interest when low affinity monoclonal antibodies (dissociation constant (Kd) > 10(-4) M) are screened, as they are not easily recognised by traditional immunoassay procedures. In this study we have evaluated this approach by monitoring low affinity monoclonal

We present spatially and spectrally resolved emission from nanowires with a thin radial layer of GaAs embedded in AlGaAs barriers, grown radially around taper-free GaAs cores. The GaAs layers are thin enough to show quantization, and are quantum wells. Due to their shape, they are referred to as quantum well tubes (QWTs). We have investigated three different nominal QWT thicknesses: 1.5, 2.0, and

Biological systems are dynamic and display heterogeneity at all levels. Ubiquitous heterogeneity, here called for poikilosis, is an integral and important property of organisms and in molecules, systems and processes within them. Traditionally, heterogeneity in biology and experiments has been considered as unwanted noise, here poikilosis is shown to be the normal state. Acceptable variation range

The name Edward Marsh occasionally crops up in handbooks on English literature, where he is mentioned as the editor of the five volumes of Georgian Poetry that appeared from 1912 to 1922. Georgian poetry, however defined, has been decried for the best part of a century, and Marsh’s reputation among representatives of English Literature has been correspondingly lacklustre. This article presents a r

Existing researches on two-row film cooling mainly focused on double-jet film cooling. However, researches on the effects by combining different kinds of hole shapes on film cooling performance are quite limited. In order to improve the film cooling effectiveness, the three-dimensional numerical method is utilized to investigate the effects of a novel structure composed of two-row holes with diffe

We study planning problems where the transition function is described by a learned binarized neural network (BNN). Theoretically, we show that feasible planning with a learned BNN model is NP-complete, and present two new constraint programming models of this task as a mathematical optimization problem. Experimentally, we run solvers for constraint programming, weighted partial maximum satisfiabil