Introduction: Severe asthma is a heterogeneous condition characterized bydistinct phenotypes and endotypes based on clinical or biologicalcharacteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2(T2) immune response, crucial for T2 inflammation. Biologic therapiestargeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies(mAbs), have shown improvements in luIntroduction: Severe asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements

Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

Ptychography is a burgeoning imaging technique that enables high-resolution, lensless reconstruction of complex samples by analysing overlapping diffraction patterns, making it invaluable in fields like materials science, biology, and nanotechnology. Real-time ptychographic reconstructions are gaining interest in the scientific community as they provide immediate feedback. Yet their potential to r

Sleep disturbances are prevalent among elderly populations and are linked to various health complications. Understanding the underlying biological mechanisms contributing to sleep disorders is crucial for developing targeted interventions. In this study, we measured 355 plasma proteins in an elderly Japanese cohort (n=77) using a high-throughput proteomic platform. Additionally, we collected over

We developed an algorithm for the early screening of autism spectrum disorder using baby cry sound. We collected the sound using a smartphone application to record it in their daily life. We employed the Japanese version of the Modified Checklist for Autism in Toddlers (M-CHAT) for the evaluation of the autism spectrum. We built a prediction model for binary classification using least absolute shr

Wastewater contains various resources and utilized simultaneously in different treatment compartments before being released into water bodies. Many municipal wastewater treatment plants are undergoing expansion and reconstruction to meet the stricter effluent requirements of the urban wastewater treatment directive (2024/3019). This situation is driving a demand for sustainable solutions character

This chapter analyses trajectories of contextual reconstruction of machine learning models with calibrated weights, sometimes known as pre-trained or foundation models, as they are made operational in specific settings. Through ethnographic vignettes on car detection, bird tracking, and medical technology, it underscores the importance of cooperation and negotiation among actors facing contingenci

This chapter argues that for public administration research to genuinely advance in non-Western contexts, scholars must at a minimum be familiar with, and ideally engage with, local cultural norms, traditions, and epistemes vis-à-vis their research. To that end, we offer a methodological shift towards ethnographic approaches to better understand and analyse contemporary PA practices, focusing on t

Animal vocalizations are extremely diverse, and evolutionary approaches to understanding this diversity assume some mapping between their acoustic form and communicative function, with specific features serving universal roles. Here, we investigate whether irregular vocal production with nonlinear phenomena contrib-utes to the alarming quality of vertebrate calls. We resynthesized 98 calls of bird

The Viking Age (c. 800–c. 1050 ad) was characterised by a widespread rise in maritime mobility and interaction, as is made clear by an increasing range of evidence. However, this evidence provides limited information about the sailors and the sailing voyages that connected and transformed the Viking world. This paper presents an approach to reconstruct Viking Age maritime itineraries through the c

Tropical forests provide essential ecosystem services, playing a critical role in climate regulation, biodiversity conservation, and regional hydrological cycles while also supporting livelihoods. However, they are increasingly threatened by deforestation and land-use change. Accurate land cover (LC) mapping is vital to monitor these changes, but mapping tropical forests is challenging due to comp

We are constantly introduced to new microtrends through the fast-paced digital landscape that we are all a part of. Barbiecore, Soft girl, Scandi-girl, Clean girl and Mob wife are examples of a few recent ones. These trends that mainly flourish on social media create ideals for women on how to dress and act online and offline. But how are the microtrends of clean girl and mob wife being received?

The aim of this thesis is to analyze how western wear is used in luxury fashion collections to represent masculinity. Historically, the western wear style is derived from the cowboy uniform in the early 1900s. Considering also that the cowboy has been portrayed as an archetype for masculinity both historically and in popular culture it is interesting to see how this archetype can portray masculini

In early 2024, the UN reported that we need to consume less to save the climate and achieve the global sustainability goals. Since the fashion industry is driven by consumption, this essay explores how the Swedish fashion industry communicates when it comes to consumption. By analyzing consumption discourses in the sustainability reports of three Swedish fashion companies, this essay examines whet

Designer fashion items hold a high status within the fashion industry. A designer brands’ culture, aesthetic, and exclusivity give their products a symbolic value that can be used by consumers to build identity or express qualities like success or wealth. Therefore it is natural that counterfeit fashion items emerge as an alternative for consumers who want to emulate these qualities, but for a che

The aim of this essay is to analyse six Vogue Scandinavia covers and their aesthetic in relation to the myth of Scandinavia and the Scandinavian aesthetic. This to grasp in what ways the covers reproduce and produce myths about the region and its aesthetic expression. With the methodological framework consisting of Roland Barthes semiotic method the six covers are semiotically analysed through den

This study will examine how fashion consumption looks on Tiktok among young women aged 18 - 19 years in Sweden. The aim is to find out which factors influence the target group's fashion consumption on Tiktok and in which specific ways Tiktok contributes to the target group's fashion consumption. To answer these questions, we will use a quantitative survey which will then be analyzed with a

In a world where insect pollinator declines are a reality, understanding their effects on the reproduction and persistence of wild plant species is vital to contribute to decisions for appropriate conservation strategies. This is especially true in areas which host a high species diversity, like European semi-natural grasslands. In fragmented habitats in particular, pollinator availability can be

Land cover and land management changes (LCLMCs) have a substantial impact on the global carbon budget and, consequently, on global climate via the biogeochemical (BGC) effects. The commonly considered BGC effects refer to the direct influence of LCLMCs on local carbon stocks (local BGC effects). However, LCLMCs also influence climate by altering the local surface energy balance due to changes in l

In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affinity for galectin-8N was determined by using FP. We evaluated the probe in a competitive FP assay w