För 50 år sedan började man operera utslitna höftleder och använda konstgjordaledytor som ersättning. Antalet operationer har långsamt ökat och operationen är nu en av de vanligaste i Sverige. En ny höftled leder oftast till total smärtfrihetoch ökad rörelseförmåga under lång tid men ibland kan de insatta delarna lossna. Omoperationer på grund av proteslossning ökar i antal och för närvarande utgö

Background: Treatment with methotrexate (MTX) in patients with rheumatoid arthritis (RA) leads to decreased total immunoglobulin (Ig) levels and impairs vaccine-specific IgG antibody levels following pneumococcal vaccination. The mechanisms by which MTX exerts these effects in RA are unknown. We aimed to evaluate whether MTX reduces vaccine-specific serum Ig levels and their functionality in RA pa

Band gap engineering in hydrogen functionalized graphene is demonstrated by changing the symmetry of the functionalization structures. Small differences in hydrogen adsorbate binding energies on graphene on Ir(111) allow tailoring of highly periodic functionalization structures favoring one distinct region of the moiré supercell. Scanning tunneling microscopy and X-ray photoelectron spectroscopy m

A linear parameter-varying (LPV) spectral decomposition method, based on least-squares estimation and kernel expansions, is developed. Statistical properties of the estimator are analyzed and verified in simulations. The method is linear in the parameters, applicable to both the analysis and modeling problems and is demonstrated on both simulated signals as well as measurements of the torque in an

Fracture propagating along the grain of timber is one of the most relevant failure mechanisms due to the wood’s low strength and its brittle failure behaviour when subjected to excessive shear and tensile stresses perpendicular to the grain. According to the current procedures, the fracture energy of wood is determined on small clear specimens. However, for the prediction of the structural behavio

New industries develop in increasingly globalized networks, whose dynamics are not well understood by academia and policy making. Solar photovoltaics (PV) are a case in point for an industry that experienced several shifts in its spatial organization over a short period of time. A lively debate has recently emerged on whether the spatial dynamics in new cleantech sectors are in line with existing

In porous materials the molecular confinement is often realized by means of weak Van der Waals interactions between the molecule and the pore surface. The understanding of the mechanism of such interactions is important for a number of applications. In order to establish the role of the confinement size we have studied the microscopic dynamics of molecular hydrogen stored in the nanocages of clath

The ‘Anthropocene’ is now being used as a conceptual frame by different communities and in a variety of contexts to understand the evolving human–environment relationship. However, as we argue in this paper, the notion of an Anthropos, or ‘humanity’, as global, unified ‘geological force’ threatens to mask the diversity and differences in the actual conditions and impacts of humankind, and does not

This paper traces the origins and early history of perceived gender differences in absenteeism in Great Britain and the USA. Among politicians and scholars, the problem was first articulated during World War I and reappeared as an issue of prime concern during World War II. The war efforts required mobilization and allocation of large numbers of women to jobs that had previously been done by men w

Control theory is one of the key intellectual underpinnings that allows us to analyze the interaction of software with the physical world. However, control theory abstracts software actions as actions that take no time to execute. In reality, software execution takes time – and this execution time can be affected by a number of platform issues, including the speed of the processor, the scheduler u

Background: Preoperative skeletal muscle depletion or sarcopenia has been suggested to predict worse outcome after resection of colorectal liver metastases. The aim of the present study was to investigate the impact of neoadjuvant chemotherapy on preoperative skeletal muscle mass prior to liver resection. Methods: Patients operated with liver resection for colorectal liver metastases between 2010

The dynamic properties of the actin cytoskeleton in smooth muscle cells play an important role in a number of cardiovascular disease states. The state of actin does not only mediate mechanical stability and contractile function but can also regulate gene expression via myocardin related transcription factors (MRTFs). These transcriptional co-activators regulate genes encoding contractile and cytos

Ultrafiltration with diafiltration is a state-of-the-art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration - batch, continuous and counter-current - and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will

Taste is the most important criteria in evaluating the quality of wine and beer. Alfa Laval's Frank Lipnizki, Carl-Erik Nielsen, Robert Betcke and Jose Caprio highlight the potential that membrane processes offer in maintaining and improving taste during production.